fMRI of Flight of Ideas in Bipolar Disorder
i-TCP
Functional Magnetic Resonance Imaging of Formal Thought Disorders in Bipolar Disorder
1 other identifier
interventional
79
1 country
1
Brief Summary
Bipolar disorder is a mental disease characterized by mood dysregulation and arises from manic, depressive or mixed episodes. The observations of the patient's speech and language behaviour due to flight of ideas or loss of goal probably result from an underlying disturbance in semantic networks dealing with semantic associations. The aim of our study will be to have a better comprehension of thought disorders in bipolar disorder by cognitive exploration of semantic processing.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P50-P75 for not_applicable
Started Aug 2013
Longer than P75 for not_applicable
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
August 1, 2013
CompletedFirst Submitted
Initial submission to the registry
May 30, 2016
CompletedFirst Posted
Study publicly available on registry
June 8, 2016
CompletedPrimary Completion
Last participant's last visit for primary outcome
April 1, 2018
CompletedStudy Completion
Last participant's last visit for all outcomes
September 1, 2018
CompletedJanuary 21, 2026
May 1, 2016
4.7 years
May 30, 2016
January 19, 2026
Conditions
Outcome Measures
Primary Outcomes (1)
brain activation profiles by Functional Magnetic Resonance Imaging
inclusion visit
Study Arms (2)
Bipolar Disorder patients
EXPERIMENTALHealthy Controls
EXPERIMENTALInterventions
Eligibility Criteria
You may qualify if:
- BD patients :
- Men or women, right-handed
- diagnosis of type 1 bipolar disorder, according to the DSM-IV criteria
- aged from 18 to 65 years-old
- Native French speaker
- Affiliated to the social security
- Healthy Controls (HC):
- Men or women, right-handed
- aged from 18 to 65 years-old
- Native French speaker
- Affiliated to the social security
You may not qualify if:
- BD patients :
- recent alcohol and/or drug abuse or dependence
- significant general medical illness, including neurological disorders or head trauma
- sensorial impairment (visual and/or hearing)
- Contraindication to the use of MRI
- HC:
- first-degree-relative history of bipolar disorder, schizophrenia or schizoaffective disorder according to DSM-IV
- recent alcohol and/or drug abuse or dependence
- significant general medical illness, including neurological disorders or head trauma
- sensorial impairment (visual and/or hearing)
- Contraindication to the use of MRI
Contact the study team to confirm eligibility.
Sponsors & Collaborators
- CHU de Reimslead
Study Sites (1)
Chu Reims
Reims, 51092, France
Related Publications (1)
Raucher-Chene D, Terrien S, Gierski F, Obert A, Caillies S, Besche-Richard C, Kaladjian A. Neural Correlates of Semantic Inhibition in Relation to Hypomanic Traits: An fMRI Study. Front Psychiatry. 2018 Apr 4;9:108. doi: 10.3389/fpsyt.2018.00108. eCollection 2018.
PMID: 29670548RESULT
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- NON RANDOMIZED
- Masking
- NONE
- Purpose
- OTHER
- Intervention Model
- PARALLEL
- Sponsor Type
- OTHER
- Responsible Party
- SPONSOR
Study Record Dates
First Submitted
May 30, 2016
First Posted
June 8, 2016
Study Start
August 1, 2013
Primary Completion
April 1, 2018
Study Completion
September 1, 2018
Last Updated
January 21, 2026
Record last verified: 2016-05