Neural Correlates of Language Control in Bilinguals. Functional MRI and Stimulation Mapping Data in Awake Surgery.

NCT02391493 | Completed

• 2 other identifiers: 13 245 03HAO 2013
• Study Type: interventional
• Target: 24
• Locations: 1 country
• Sites: 1

Brief Summary

For bilingual and multilingual patients, brain activation and Electric Stimulation Mapping studies have shown that different languages may be localized, at least partially, in distinct microanatomical systems located within the same gross anatomical areas. The present investigation involves both types of healthy bilinguals with carefully controlled proficiency levels, as well as bilingual patients suffering from low-grade glioma. Functional magnetic resonance imaging data will be collected while the participants perform a picture naming task in blocked conditions for both languages (either English or French) or in switch condition (English and French). A stimulation mapping study will be conducted in the patients during awake surgery with the same tasks.

Conditions

Bilingualism

Keywords

bilinguals; language control; executive functions; functional MRI; stimulation mapping; brain tumors

Outcome Measures

Primary Outcomes (1)

• Brain activity

  The primary judgment criteria is brain activity as measured by functional magnetic resonance imaging : * In blocked vs. switched naming in control subjects * In switched naming in early vs. late bilingual subjects * In blocked vs. switched naming in early vs. late bilingual subjects

  24 hours

Secondary Outcomes (1)

• Brain activity

  24 hours

Study Arms (3)

healthy early bilinguals

EXPERIMENTAL

healthy early bilinguals functional magnetic resonance imaging

Device: functional magnetic resonance imaging

healthy late bilinguals

EXPERIMENTAL

healthy late bilinguals functional magnetic resonance imaging

Device: functional magnetic resonance imaging

bilingual patients

EXPERIMENTAL

bilingual patients suffering from low-grade glioma in the language areas functional magnetic resonance imaging

Device: functional magnetic resonance imaging

Interventions

functional magnetic resonance imaging DEVICE

Stimuli will be presented in 3 language conditions, French, English and "switch" in which the participant alternates between English and French every trial. A block design will be used, with 7 line drawings per language condition. Four 9-minute runs will be performed, there being 2 action runs and 2 object runs. In each run, there are 6 blocks of each language condition, presented in a fixed random order. No drawings are repeated. Each stimulus is preceded either by an English or a French prompt word ("to" or "faire" for actions and, "say" or "dire" for objects) for 450 msec; stimuli are presented for 1.5 seconds and followed by a blank screen for 1 second. Language blocks are separated by a variable duration (from 8 to 10 seconds).

bilingual patients; healthy early bilinguals; healthy late bilinguals

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Patients:
• Bilingual patients with a pathology indicating an intervention in awake surgery (e.g. low-grade glioma)
• At least C1-level of the CECR in both languages
• At least 12 years of schooling (French BAC)
• Right-handed (Edinburgh test, 1971)
• Performance indicator Eastern Cooperative Oncology Group 0-2 (cf. annexe)
• Life expectation \> 6 month
• Affiliated to social insurance
• Having given informed consent
• Healthy volunteers:
• French-English or English-French bilinguals with at least a C1 level (CECR) in both languages
• At least 12 years of schooling (French BAC)
• Right-handed (Edinburgh test, 1971)
• Early bilinguals: age of acquisition of both languages \< 3 years
• Late bilinguals: age of acquisition of the L2 \> 10 years

You may not qualify if:

• Patients:
• Contra-indication for MRI
• Left-handed or ambidexter (less than +80 at the Edinburgh test - 1971)
• Mini-Mental State Examination \<26
• Patient who cannot respect the procedures, visits, exams described in the protocol
• Healthy volunteers:
• Contra-indication for MRI
• Mini-Mental State Examination \< 26
• Age of acquisition of one of the language between 3 and 10 years

Sponsors & Collaborators

• University Hospital, Toulouse: lead

Study Sites (1)

University Hospital of Toulouse

Toulouse, 31059, France

Location

MeSH Terms

Conditions

Brain Neoplasms

Interventions

Magnetic Resonance Imaging

Condition Hierarchy (Ancestors)

Central Nervous System Neoplasms; Nervous System Neoplasms; Neoplasms by Site; Neoplasms; Brain Diseases; Central Nervous System Diseases; Nervous System Diseases

Intervention Hierarchy (Ancestors)

Tomography; Diagnostic Imaging; Diagnostic Techniques and Procedures; Diagnosis

Study Officials

• Vincent LUBRANO, MD, PhD

  University Hospital, Toulouse

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NON RANDOMIZED
• Masking: NONE
• Purpose: BASIC SCIENCE
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: March 4, 2015
• First Posted: March 18, 2015
• Study Start: November 1, 2014
• Primary Completion: December 1, 2017
• Study Completion: December 1, 2017
• Last Updated: March 27, 2018

Record last verified: 2018-03

Locations

FR (1)