NCT02882386

Brief Summary

The aim of this study is to investigate the amino acid kinetics in blood after a bout of strength training and ingestion of different milk protein supplements (native whey, whey protein concentrate 80, hydrolysed whey, microparticulated whey and milk) The investigators hypothesize that native whey will give a faster and higher rise in blood concentrations of leucine compared to the other milk protein supplements.

Trial Health

100
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
13

participants targeted

Target at below P25 for not_applicable

Timeline
Completed

Started Sep 2012

Shorter than P25 for not_applicable

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

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Study Timeline

Key milestones and dates

Study Start

First participant enrolled

September 1, 2012

Completed
1 month until next milestone

Primary Completion

Last participant's last visit for primary outcome

October 1, 2012

Completed
4 months until next milestone

Study Completion

Last participant's last visit for all outcomes

February 1, 2013

Completed
3.5 years until next milestone

First Submitted

Initial submission to the registry

August 16, 2016

Completed
13 days until next milestone

First Posted

Study publicly available on registry

August 29, 2016

Completed
Last Updated

August 29, 2016

Status Verified

August 1, 2016

Enrollment Period

1 month

First QC Date

August 16, 2016

Last Update Submit

August 24, 2016

Conditions

Healthy Participants

Outcome Measures

Primary Outcomes (1)

  • Plasma amino acid concentration change from baseline

    Blood collected at 0, 30, 45, 60, 90 and 120 min after consumption of protein supplements

Secondary Outcomes (6)

  • Serum glucose change from baseline

    Blood collected at 0, 30, 45, 60, 90 and 120 min after consumption of protein supplements

  • Serum urea change from baseline

    Blood collected at 0, 30, 45, 60, 90 and 120 min after consumption of protein supplements. For milk and native whey blood was collected at two additional time points: 22 and 30 hours after consumption of protein supplements

  • Muscle force generating capacity change from baseline

    Measured before and at 0, 6, 22 and 30 hours after exercise. Only measured after milk and native whey

  • Jump height change from baseline

    Measured before and at 0, 6, 22 and 30 hours after exercise. Only measured after milk and native whey

  • Serum creatine kinase change from baseline

    Blood collected at 0, 30, 45, 60, 90 and 120 min after consumption of protein supplements. For milk and native whey blood was collected at two additional time points: 22 and 30 hours after consumption of protein supplements

  • +1 more secondary outcomes

Study Arms (5)

Milk 1%

PLACEBO COMPARATOR

Participants performed a bout of strength training and consumed 636 ml of a protein supplement

Other: Strength TrainingDietary Supplement: Milk 1%

Whey protein concentrate 80 (WPC-80)

EXPERIMENTAL

Participants performed a bout of strength training and consumed 636 ml of a protein supplement

Other: Strength TrainingDietary Supplement: Whey protein concentrate 80 (WPC-80)

Microparticulated whey

EXPERIMENTAL

Participants performed a bout of strength training and consumed 636 ml of a protein supplement

Other: Strength TrainingDietary Supplement: Microparticulated whey

Hydrolyzed whey

EXPERIMENTAL

Participants performed a bout of strength training and consumed 636 ml of a protein supplement

Other: Strength TrainingDietary Supplement: Hydrolyzed whey

Native whey

EXPERIMENTAL

Participants performed a bout of strength training and consumed 636 ml of a protein supplement

Other: Strength TrainingDietary Supplement: Native whey

Interventions

Strength TrainingOTHER
Hydrolyzed wheyMicroparticulated wheyMilk 1%Native wheyWhey protein concentrate 80 (WPC-80)
Milk 1%DIETARY_SUPPLEMENT
Also known as: Protein supplementation
Milk 1%
Whey protein concentrate 80 (WPC-80)DIETARY_SUPPLEMENT
Also known as: Protein supplementation
Whey protein concentrate 80 (WPC-80)
Microparticulated wheyDIETARY_SUPPLEMENT
Also known as: Protein supplementation
Microparticulated whey
Hydrolyzed wheyDIETARY_SUPPLEMENT
Also known as: Protein supplementation
Hydrolyzed whey
Native wheyDIETARY_SUPPLEMENT
Also known as: Protein supplementation
Native whey

Eligibility Criteria

Age18 Years - 45 Years
Sexmale
Healthy VolunteersYes
Age GroupsAdult (18-64)

You may qualify if:

  • Healthy in the sense that they can conduct training and testing
  • Able to understand Norwegian language written and oral

You may not qualify if:

  • Diseases or injuries contraindicating participation
  • Use of dietary supplements (e.g. proteins, vitamins and creatine)
  • Lactose intolerance
  • Allergy to milk
  • Allergy towards local anesthetics (xylocain)

Contact the study team to confirm eligibility.

Sponsors & Collaborators

MeSH Terms

Interventions

Resistance Training

Intervention Hierarchy (Ancestors)

Exercise TherapyRehabilitationAftercareContinuity of Patient CarePatient CareTherapeuticsPhysical Therapy ModalitiesPhysical Conditioning, HumanExerciseMotor ActivityMovementMusculoskeletal Physiological PhenomenaMusculoskeletal and Neural Physiological Phenomena

Study Officials

  • Truls Raastad, PhD

    Norwegian School of Sport Sciences

    PRINCIPAL INVESTIGATOR

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
QUADRUPLE
Who Masked
PARTICIPANT, CARE PROVIDER, INVESTIGATOR, OUTCOMES ASSESSOR
Purpose
BASIC SCIENCE
Intervention Model
CROSSOVER
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
PhD student

Study Record Dates

First Submitted

August 16, 2016

First Posted

August 29, 2016

Study Start

September 1, 2012

Primary Completion

October 1, 2012

Study Completion

February 1, 2013

Last Updated

August 29, 2016

Record last verified: 2016-08