Neural and Behavioural Bases of Action Simulation

NCT06836297 | Not Yet Recruiting

• 1 other identifier: NBBAS
• Study Type: interventional
• Target: 300
• Locations: 0 countries
• Sites: N/A

Brief Summary

The goal of this interventional study is to understand the neural and behavioural bases of action simulation and its links with action execution in healthy volunteers. Hypotheses: Action simulation recruits neural networks that are largely similar to those activated by action execution, with some differences to avoid executing a movement while observing/imagining it. Participants will be tested with TMS while doing motor imagery or action observation.

Conditions

Healthy Participants

Outcome Measures

Primary Outcomes (1)

• Motor Evoked Potential (MEP)

  Evoked motor potentials will be measured throughout the experiment using surface electrodes on different muscles to measure changes in corticospinal excitability.

  For the duration of the participants' visit to the laboratory (max 2h30)

Study Arms (1)

Transcranial Magnetic Stimulation

EXPERIMENTAL

For some experiments, all participants will take part in all experimental conditions. For other experiments, participants will be randomly assigned to different groups with different conditions (e.g. TMS sham vs. TMS test).

Device: Transcranial Magnetic Stimulation Sham

Interventions

Transcranial Magnetic Stimulation Sham DEVICE

Participants will be asked to perform various behavioral tasks involving the use of action observation or motor imagery. During these tasks, transcranial magnetic stimulation will be used.

Transcranial Magnetic Stimulation

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• healthy adult volunteers (more than 18 years old)

You may not qualify if:

• Participants taking anti-epileptic drugs
• pregnant or breastfeeding women cannot participate in this study
• people with a pacemaker
• people with a cochlear implant
• people with a metal part in the brain or any other medical implant in their body (pump, neurostimulator, valve,) cannot take part in this study.

Sponsors & Collaborators

• Université Catholique de Louvain: lead

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Purpose: BASIC SCIENCE
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: February 10, 2025
• First Posted: February 20, 2025
• Study Start: March 1, 2025
• Primary Completion (Estimated): February 1, 2028
• Study Completion (Estimated): February 1, 2028
• Last Updated: February 20, 2025

Record last verified: 2025-02

Data Sharing

• IPD Sharing: Will not share