Decision-Making and the Relationship to Food Intake in Kids

NCT02855398 | Completed

• 1 other identifier: DecisionMakingEatingKids01
• Study Type: observational
• Target: 142
• Locations: 1 country
• Sites: 1

Brief Summary

The purpose of this 18-month project is to investigate how decision-making influences food choice and consumption in children ages 7 to 11 years old. Although several studies suggest that the ability to make good decisions relates to eating behaviors, no studies have looked at how food reward influences the decision-making process to impact actual food intake. This proposal will answer these questions and bridge this gap in knowledge, which could lead to the development of more effective interventions for childhood obesity. To accomplish this, the investigators have assembled a diverse team with expertise in food intake, nutrition, and decision sciences. First, the investigators will establish if there are differences in decision-making between children varying in weight status. Second, the investigators will determine if performance on behavioral decision-making tasks relates to food consumption in the laboratory. Third, the investigators will examine response functional magnetic resonance imaging (fMRI) blood-oxygen-level-dependent (BOLD) response to various rewards (i.e. food and money) and determine if this is influenced by child weight status. Fourth, the investigators will examine differences in fMRI BOLD at rest in decision-making regions are correlated with food intake and weight status. Eighty-two children will participate in our study. The long-term goal of this project is to investigate if there are differences in brain regions corresponding to these behaviors in overweight children and if these differences relate to eating behaviors in this population. Children will undergo fMRI while playing a reward task as well as consume meals in our laboratory. Decision-making will also be assessed by having children complete various behavioral measurements of reward and inhibitory control.

Conditions

Pediatric Obesity

Outcome Measures

Primary Outcomes (6)

• Functional magnetic resonance imaging (fMRI), blood-oxygen-level-dependent (BOLD) response to various reward types (food, money, no reward).

  Regions of interest BOLD analysis of an fMRI card-guessing task for various reward types

  Collected at fMRI scan at week 4

• Functional magnetic resonance imaging (fMRI), blood-oxygen-level-dependent (BOLD) response at rest (resting-state fMRI)

  Regions of interest BOLD analysis of resting-state fMRI to examine differences in brain regions of interest at rest

  Collected at fMRI scan at week 4

• Behavioral inhibitory control task

  Measured by performance on a go/nogo task

  Collected at either week 1-3 (randomized)

• Behavioral reward inhibitory control task

  Measured by performance on a go/nogo task with a reward incentive

  Collected after the behavioral inhibitory control task (same visit), which is either week 1-3 (randomized)

• Behavioral risk-taking and reward task

  Measured by performance on the hungry donkey task

  Collected at either week 1-3 (randomized)

• Behavioral dietary self-control assessment

  Measured by performance on a dietary self-control task

  Collected at either week 1-3 (randomized)

Secondary Outcomes (5)

• Energy intake at baseline

  Collected at either week 1-3 (randomized)

• Energy intake at a buffet meal

  Collected at either week 1-3 (randomized)

• Energy intake after a meal preload

  Collected at either week 1-3 (randomized) following the baseline meal

• Functional magnetic resonance imaging (fMRI), blood-oxygen-level-dependent (BOLD) response to various reward types (food, money, no reward).

  Collected at week 4

• Functional magnetic resonance imaging (fMRI), blood-oxygen-level-dependent (BOLD) response at baseline

  Collected at week 4

Other Outcomes (22)

• Liking of foods

  Collected after each meal at multiple time points during weeks 1-4

• Fullness feelings

  Collected at multiple time points during weeks 1-4

• Pubertal Development

  Collected at week 1

Eligibility Criteria

• Age: 7 Years - 11 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Child (0-17)
• Sampling Method: Probability Sample

Study Population

Children aged 7-11 years old.

You may qualify if:

• Right-handed
• English as native language
• Reading at/above grade level
• Not Claustrophobic
• Generally Healthy

You may not qualify if:

• Left-handedness
• Metal in or on body that cannot be removed
• Claustrophobia
• Medication usage that may alter brain activity or blood flow
• Medical disorder that may impact comfort of safety in MRI scanner
• Food Allergies
• Dietary Restrictions
• Learning Disabilities
• Psychiatric Disorders

Sponsors & Collaborators

• Penn State University: lead

Study Sites (1)

The Pennsylvania State University

University Park, Pennsylvania, 16802, United States

Location

Related Publications (2)

• Adise S, White CN, Roberts NJ, Geier CF, Keller KL. Children's inhibitory control abilities in the presence of rewards are related to weight status and eating in the absence of hunger. Appetite. 2021 Dec 1;167:105610. doi: 10.1016/j.appet.2021.105610. Epub 2021 Jul 26.

  PMID: 34324909 DERIVED

• Adise S, Geier CF, Roberts NJ, White CN, Keller KL. Is brain response to food rewards related to overeating? A test of the reward surfeit model of overeating in children. Appetite. 2018 Sep 1;128:167-179. doi: 10.1016/j.appet.2018.06.014. Epub 2018 Jun 8.

  PMID: 29890186 DERIVED

MeSH Terms

Conditions

Pediatric Obesity

Condition Hierarchy (Ancestors)

Obesity; Overweight; Overnutrition; Nutrition Disorders; Nutritional and Metabolic Diseases; Body Weight; Signs and Symptoms; Pathological Conditions, Signs and Symptoms

Study Officials

• Shana Adise, B.S.

  The Pennsylvania State University

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: OTHER
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Assistant Professor, Department of Nutritional Sciences and Food Science

Study Record Dates

• First Submitted: June 29, 2016
• First Posted: August 4, 2016
• Study Start: April 1, 2015
• Primary Completion: October 1, 2016
• Study Completion: December 1, 2017
• Last Updated: January 11, 2021

Record last verified: 2021-01

Data Sharing

• IPD Sharing: Will not share

Locations

US (1)