Sponsor study identifier
observational
108
0 countries
N/A
Study Start
July 2013
Date type not reportedThis date has not been verified as actual or estimated.
Primary Completion
July 2015
Actual (reported)Study Completion
December 2015
Actual (reported)Increased portion sizes of foods high in energy density (calories per gram of food) have been implicated in the obesity epidemic. Numerous studies show that children and adults eat more from larger portions of food than they do from smaller portions, a response known as the portion size effect. Despite the robust and consistent nature of these findings, the mechanisms underlying the portion size effect are not known. The long-term goal of this research is to identify the neural mechanisms involved in the portion size effect so that this information can be used to develop effective weight-management strategies. Differences in neural response to food cues, as demonstrated by functional magnetic resonance imaging (fMRI), can help clarify the factors that determine susceptibility to large portions. The goal of this study is to identify brain regions activated in response to portion size and energy density and relate these neural responses to laboratory eating behaviors in children. The investigators hypothesize that high relative to low energy density food images will be associated with increased activation in regions of the brain involved in reward- and sensory- processing and that large relative to small portion size food images will be associated with increased activation in regions of the brain involved in cognitive control. In addition, the investigators hypothesize that these brain responses will influence the relationship between portion size served and energy intake at laboratory meals.
Registry-reported information. Elapsed time and enrollment totals alone do not measure study progress or recruitment pace.
December 2015
Actual (reported)Click on a node to explore related trials.
Dates and qualifiers reported by the registry. Estimated dates do not confirm that a milestone has occurred.
July 2013
Date type not reportedThis date has not been verified as actual or estimated.
July 2015
Actual (reported)December 2015
Actual (reported)April 26, 2016
Actual (reported)May 3, 2016
Actual (reported)fMRI blood oxygen level dependent (BOLD) response to food portion size and energy density
Whole-brain response to food images that varied at 2 levels of portion size and 2 levels of energy density
Collected at fMRI scan (1 of 1) at week 5
Energy intake
Energy intake (kcal and grams) of foods consumed ad libitum at each laboratory test-meal in response to 4 conditions of portion sizes (100% reference, 133%, 167%, 200%).
Collected at week 1, 2, 3, and 4
Region of Interest (ROI)-response to food portion size and energy density
Collected at fMRI scan (1 of 1) at week 5
Appetitive traits
Collected at week 1 (Baseline)
Body composition a/o weight status
Collected at week 1 (Baseline)
Liking of foods
Collected at week 5
Children between the ages of 7-10 years old and their parents
English L, Lasschuijt M, Keller KL. Mechanisms of the portion size effect. What is known and where do we go from here? Appetite. 2015 May;88:39-49. doi: 10.1016/j.appet.2014.11.004. Epub 2014 Nov 11.
Fearnbach SN, English LK, Lasschuijt M, Wilson SJ, Savage JS, Fisher JO, Rolls BJ, Keller KL. Brain response to images of food varying in energy density is associated with body composition in 7- to 10-year-old children: Results of an exploratory study. Physiol Behav. 2016 Aug 1;162:3-9. doi: 10.1016/j.physbeh.2016.03.007. Epub 2016 Mar 10.
Kathleen Keller, PhD
The Pennsylvania State University
108 participants (actual enrollment reported by the registry).
First Submitted
April 26, 2016
First Posted
May 3, 2016
Study Start
July 2013
Date type not reportedThis date has not been verified as actual or estimated.
Children's Taste Study to Increase Vegetable Intake in Preschoolers
Contact the study team to confirm eligibility.
Neuwald NV, Pearce AL, Cunningham PM, Setzenfand MN, Koczwara L, Rolls BJ, Keller KL. Food switching at a meal is positively associated with change in adiposity among children at high-familial risk for obesity. Appetite. 2025 Apr 1;208:107915. doi: 10.1016/j.appet.2025.107915. Epub 2025 Feb 25.
Diktas HE, Keller KL, Roe LS, Rolls BJ. Children's Portion Selection Is Predicted by Food Liking and Is Related to Intake in Response to Increased Portions. J Nutr. 2022 Oct 6;152(10):2287-2296. doi: 10.1093/jn/nxac162.
Keller KL, English LK, Fearnbach SN, Lasschuijt M, Anderson K, Bermudez M, Fisher JO, Rolls BJ, Wilson SJ. Brain response to food cues varying in portion size is associated with individual differences in the portion size effect in children. Appetite. 2018 Jun 1;125:139-151. doi: 10.1016/j.appet.2018.01.027. Epub 2018 Feb 2.
Primary Completion
July 2015
Actual (reported)Study Completion
December 2015
Actual (reported)Last Updated
December 17, 2020
Record last verified: 2020-12
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Source: ClinicalTrials.gov.
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