Potentially Inappropriate Prescription Associated to Multimorbidity

NCT02830425 | Completed

• 1 other identifier: PI15/00552
• Study Type: observational
• Target: 740
• Locations: 1 country
• Sites: 1

Brief Summary

A prospective multicenter cohort study in 5 hospitals in Spain will be initiated in 2016. Objectives:

1. 1.To estimate and describe patterns of multimorbidity and polypharmacy in patients over 64 admitted for a chronic disease exacerbation.
2. 2.To analyze the potentially inappropriate prescribing (PPI) drugs according to STOPP / START (SS) criteria.
3. 3.To evaluate the relationship between multimorbidity and PPI and adverse medication (RAM) preventable reaction.

Conditions

Chronic Disease

Keywords

Multimorbidity; Polypharmacy; Appropriateness; STOPP; START

Outcome Measures

Primary Outcomes (1)

• Percentage of patients with Potentially inappropriate medication, according to STOPP-START explicit criteria

  At study entry

Secondary Outcomes (4)

• Percentage of patients with Potentially inappropriate medication, according to STOPP-START explicit criteria

  Through study completion, an average of 2 years

• Percentage of patients with polypharmacy

  At study entry

• Patients with any treatment-related adverse events (ADR), according to the Wills & Brown classification

  Through study completion, an average of 2 years

• Percentage of different Patterns of multimorbidity in chronic patients, according to clusters or associations of different chronic conditions

  At study entry

Interventions

No intervention OTHER

Eligibility Criteria

• Age: 65 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Elderly with any chronic condition admitted in Internal Medicine or Geriatrics department because of an exacerbation of any chronic condition

You may qualify if:

• Patient admitted to the Internal Medicine or Geriatrics department
• Admitted to hospital because of an exacerbation of any previous chronic condition

You may not qualify if:

• Terminal ill patients at admission
• Patients with lower forecast life than 1 year
• Patient admitted to the hospital only because an acute problem
• In patient home care

Sponsors & Collaborators

• Corporacion Parc Tauli: lead
• Fondo de Investigacion Sanitaria: collaborator
• Hospital del Mar: collaborator
• Hospital de Galdakao: collaborator
• Consorci Hospitalari de Vic: collaborator
• Hospital Universitario de Canarias: collaborator

Study Sites (1)

Corporacio Parc Taulí

Sabadell, 08208, Spain

Location

Related Publications (5)

• Bare M, Herranz S, Jordana R, Gorgas MQ, Ortonobes S, Sevilla D, De Jaime E, Ibarra O, Martin C; MoPIM study group. Multimorbidity patterns in chronic older patients, potentially inappropriate prescribing and adverse drug reactions: protocol of the multicentre prospective cohort study MoPIM. BMJ Open. 2020 Jan 26;10(1):e033322. doi: 10.1136/bmjopen-2019-033322.

  PMID: 31988230 BACKGROUND

• Ortonobes S, Herranz S, Lleal M, Sevilla-Sanchez D, Jordana R, Mascaro O, Ferrandez O, de Jaime E, Estrada R, Nazco GJ, Bare M; MoPIM Study Group. Multidisciplinary medication review during older patient hospitalization according to STOPP/START criteria reduces potentially inappropriate prescriptions: MoPIM cohort study. BMC Geriatr. 2024 Jul 8;24(1):584. doi: 10.1186/s12877-024-05185-w.

  PMID: 38978009 DERIVED

• Lleal M, Bare M, Ortonobes S, Sevilla-Sanchez D, Jordana R, Herranz S, Gorgas MQ, Espaulella-Ferrer M, Arellano M, de Antonio M, Nazco GJ, Hernandez-Luis R, On Behalf Of The MoPIM Study Group. Comprehensive Multimorbidity Patterns in Older Patients Are Associated with Quality Indicators of Medication-MoPIM Cohort Study. Int J Environ Res Public Health. 2022 Nov 29;19(23):15902. doi: 10.3390/ijerph192315902.

  PMID: 36497976 DERIVED

• Bare M, Lleal M, Ortonobes S, Gorgas MQ, Sevilla-Sanchez D, Carballo N, De Jaime E, Herranz S; MoPIM study group. Factors associated to potentially inappropriate prescribing in older patients according to STOPP/START criteria: MoPIM multicentre cohort study. BMC Geriatr. 2022 Jan 11;22(1):44. doi: 10.1186/s12877-021-02715-8.

  PMID: 35016636 DERIVED

• Bare M, Herranz S, Roso-Llorach A, Jordana R, Violan C, Lleal M, Roura-Poch P, Arellano M, Estrada R, Nazco GJ; MoPIM study group. Multimorbidity patterns of chronic conditions and geriatric syndromes in older patients from the MoPIM multicentre cohort study. BMJ Open. 2021 Nov 15;11(11):e049334. doi: 10.1136/bmjopen-2021-049334.

  PMID: 34782339 DERIVED

MeSH Terms

Conditions

Chronic Disease

Condition Hierarchy (Ancestors)

Disease Attributes; Pathologic Processes; Pathological Conditions, Signs and Symptoms

Study Officials

• Marisa Baré, MD, MPH, PhD

  Corporacio Parc Taulí

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Cancer Screening-Epidemiology Coordinator

Study Record Dates

• First Submitted: July 1, 2016
• First Posted: July 12, 2016
• Study Start: January 1, 2016
• Primary Completion: July 1, 2019
• Study Completion: December 1, 2019
• Last Updated: April 9, 2020

Record last verified: 2020-04

Locations

ES (1)