The Hordaland Health Study

NCT03013725 | Completed

• 1 other identifier: HUSK9799
• Study Type: observational
• Target: 36,000
• Locations: 0 countries
• Sites: N/A

Brief Summary

The Hordaland Health Studies (HHS) were conducted in 1992-93 (The Homocysteine study) and in 1997-99 (HUSK). Both surveys were conducted as a joint project between the University of Bergen, the Norwegian Health Screening Service (SHUS) (now part of the National Institute of Public Health) and the Municipal Health Service in Hordaland. The main focus of the studies is on chronic diseases including cardiovascular disease, cancer, osteoporosis, anxiety and depression. Some projects focus on psychosocial factors, occupational research, musculoskeletal diseases, urinary incontinence and mapping of drug use. The main purpose of the surveys is to gather information so that disease ultimately can be prevented. Approximately 36,000 residents of Hordaland county participated in the studies, ca. 18,000 in 1992-93 and ca. 26,000 in 1997-99. About 7,000 of those who participated in the 1992-93 survey also participated in 1997-99.

Conditions

Chronic Disease

Outcome Measures

Primary Outcomes (1)

• Total mortality.

  The unique 11-digit personal identification number assigned to all Norwegian residents facilitates linkage between HHS and the Norwegian Population Register, which contains information on vital status (alive, emigrated, or dead). The follow-up period varies from 16 - 23 years, depending on whether first or second measurement is used as baseline.

  Participants are followed from baseline (1992-93 or 1997-99) until death or December 31st, 2015.

Secondary Outcomes (1)

• Mortality or morbidity from chronic diseases (for example cardiovascular disease, cancer). Also, award of disability pension are used as an outcome.

  Participants are followed from baseline (1992-93 or 1997-99) until time of diagnosis/death from disease or the last day of follow-up.

Study Arms (2)

The Homocysteine Study

Conducted in 1992-93, ca. 18000 participated.

Other: No intervention

The Hordaland Health Study (HUSK)

Conducted in 1997-99, ca. 26000 participated.

Other: No intervention

Interventions

No intervention OTHER

No intervention

The Homocysteine Study; The Hordaland Health Study (HUSK)

Eligibility Criteria

• Age: 40 Years - 74 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

Approximately 36,000 residents of Hordaland county participated in the studies (both men and women), ca. 18,000 in 1992-93 and ca. 26,000 in 1997-99. About 7,000 of those who participated in the 1992-93 survey also participated in 1997-99.

You may qualify if:

• Born in a specific time-period
• From Hordaland County
• Community-dwelling people who were able to come to the study site on their own, and able to fill out questionnaires.

You may not qualify if:

• Not born within the specific time-period
• Not from Hordaland County
• Institutionalized People
• People who were not able to fill out questionnaires

Sponsors & Collaborators

• University of Bergen: lead
• Part of CONOR, and participates in the Norwegian Epidemiologic Osteoporosis Studies: collaborator

Related Publications (2)

• Haugsgjerd TR, Egeland GM, Nygard OK, Vinknes KJ, Sulo G, Lysne V, Igland J, Tell GS. Association of dietary vitamin K and risk of coronary heart disease in middle-age adults: the Hordaland Health Study Cohort. BMJ Open. 2020 May 21;10(5):e035953. doi: 10.1136/bmjopen-2019-035953.

  PMID: 32444431 DERIVED

• Zuo H, Tell GS, Ueland PM, Nygard O, Vollset SE, Midttun O, Meyer K, Ulvik A. The PAr index, an indicator reflecting altered vitamin B-6 homeostasis, is associated with long-term risk of stroke in the general population: the Hordaland Health Study (HUSK). Am J Clin Nutr. 2018 Jan 1;107(1):105-112. doi: 10.1093/ajcn/nqx012.

  PMID: 29381795 DERIVED

Biospecimen

Retention: SAMPLES WITHOUT DNA

Blood samples are stored at two biobanks located in Bergen and Levanger. The blood was divided in full blood, plasma and serum.

MeSH Terms

Conditions

Chronic Disease

Condition Hierarchy (Ancestors)

Disease Attributes; Pathologic Processes; Pathological Conditions, Signs and Symptoms

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Professor

Study Record Dates

• First Submitted: December 19, 2016
• First Posted: January 6, 2017
• Study Start: January 1, 1992
• Primary Completion: June 1, 1999
• Study Completion: June 1, 1999
• Last Updated: January 6, 2017

Record last verified: 2017-01