NCT05717309

Brief Summary

Following the MRisk-COVID project, MTOP (Multimorbidity Trajectories in Older Patients) study was developed. It is a retrospective observational study using Real World Data that aims to identify patterns of chronic multimorbidity in patients aged ≥65 years and their evolution and trajectories in the previous 10 years. The secondary objective is to identify the relationship between the trajectories of multimorbidity patterns in the previous 10 years and the severity of the infection by COVID-19.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
3,988

participants targeted

Target at P75+ for all trials

Timeline
Completed

Started Feb 2022

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

February 10, 2022

Completed
11 months until next milestone

Primary Completion

Last participant's last visit for primary outcome

January 17, 2023

Completed
8 days until next milestone

First Submitted

Initial submission to the registry

January 25, 2023

Completed
14 days until next milestone

First Posted

Study publicly available on registry

February 8, 2023

Completed
6 months until next milestone

Study Completion

Last participant's last visit for all outcomes

July 31, 2023

Completed
Last Updated

August 24, 2023

Status Verified

August 1, 2023

Enrollment Period

11 months

First QC Date

January 25, 2023

Last Update Submit

August 23, 2023

Conditions

Chronic Disease

Keywords

MultimorbidityCluster analysisTrajectoriesOlder patientCOVID-19

Outcome Measures

Primary Outcomes (4)

  • Chronic multimorbidity patterns - Time Frame 1

    Obtained using fuzzy c-means cluster analysis

    Baseline (2020)

  • Chronic multimorbidity patterns - Time Frame 2

    Obtained using fuzzy c-means cluster analysis

    5 years before (2015)

  • Chronic multimorbidity patterns - Time Frame 3

    Obtained using fuzzy c-means cluster analysis

    10 years before (2010)

  • Trajectories of chronic multimorbidity patterns

    Obtained by assigning the highest probable cluster at each time point

    Change over 10 years

Secondary Outcomes (1)

  • Severe COVID-19 infection

    From 27-February-2020 to 15-June-2020

Eligibility Criteria

Age65 Years - 94 Years
Sexall
Age GroupsOlder Adult (65+)
Sampling MethodNon-Probability Sample
Study Population

Confirmed or suspected COVID-19 patients from the first wave of the pandemic, aged 65 years and over, residing in a healthcare region of about 400.000 inhabitants in a Northeast region of Spain (Vallès Occidental Est, Catalonia, Spain).

You may qualify if:

  • Positive results of COVID-19 laboratory tests
  • COVID-19 related clinical profile verified by healthcare professionals

You may not qualify if:

  • Males \>90 years (re-identification risk)

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Corporacio Parc Taulí

Sabadell, Barcelona, 08208, Spain

Location

Related Publications (1)

  • Lleal M, Bare M, Herranz S, Orus J, Comet R, Jordana R, Bare M. Trajectories of chronic multimorbidity patterns in older patients: MTOP study. BMC Geriatr. 2024 May 30;24(1):475. doi: 10.1186/s12877-024-04925-2.

    PMID: 38816787DERIVED

MeSH Terms

Conditions

Chronic DiseaseCOVID-19

Condition Hierarchy (Ancestors)

Disease AttributesPathologic ProcessesPathological Conditions, Signs and SymptomsPneumonia, ViralPneumoniaRespiratory Tract InfectionsInfectionsVirus DiseasesCoronavirus InfectionsCoronaviridae InfectionsNidovirales InfectionsRNA Virus InfectionsLung DiseasesRespiratory Tract Diseases

Study Design

Study Type
observational
Observational Model
COHORT
Time Perspective
RETROSPECTIVE
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Principal Investigator

Study Record Dates

First Submitted

January 25, 2023

First Posted

February 8, 2023

Study Start

February 10, 2022

Primary Completion

January 17, 2023

Study Completion

July 31, 2023

Last Updated

August 24, 2023

Record last verified: 2023-08

Locations

ES(1)