Eating Disinhibition and Vagal Tone and the Postprandial Response to Glycaemic Load

NCT02827318 | Completed

• 1 other identifier: DisGL
• Study Type: interventional
• Target: 66
• Locations: 1 country
• Sites: 1

Brief Summary

Reducing the glycaemic load (GL) of the diet may benefit appetite control but its utility is complicated by psychological influences on eating. Disinhibited behaviour, a risk factor for overconsumption, is characterized by reduced prefrontal cortex activity, which in turn directly modulates vagal tone; a phenomenon inversely associated with blood glucose (BG) and insulin levels. This double blind randomised controlled trial explores the influence of disinhibited eating and vagal tone (heart rate variability) on the postprandial response to GL and hunger.

Conditions

Hunger

Keywords

Blood glucose

Outcome Measures

Primary Outcomes (2)

• Change in blood glucose

  Blood glucose was monitored from finger pricks using an ExacTech sensor (Medisense Britain Limited) that using an enzymic method, coupled with microelectronic measurement. Change in blood glucose from baseline to after 30 minutes will assess the speed of incline.

  From baseline to 30 minutes

• Change in blood glucose

  As above to assess the speed of decline.

  from 30 to 150minutes

Secondary Outcomes (1)

• Hunger

  30, 150 minutes

Study Arms (3)

75g glucose

ACTIVE COMPARATOR

75g of glucose dissolved in 500ml provided in a clear plastic tumbler.

Dietary Supplement: Glucose

75g isomaltulose

EXPERIMENTAL

75g of isomaltulose dissolved in 500ml provided in a clear plastic tumbler.

Dietary Supplement: Isomaltulose

Sweetened water

PLACEBO COMPARATOR

500ml water sweetened with sucralose provided in a clear plastic tumbler.

Dietary Supplement: Sweetened water

Interventions

Isomaltulose DIETARY_SUPPLEMENT

75g Isomaltulose (low glycaemic load intervention)

75g isomaltulose

Glucose DIETARY_SUPPLEMENT

75g Glucose (high glycaemic load intervention)

75g glucose

Sweetened water DIETARY_SUPPLEMENT

Sweetened water will be used as a control

Sweetened water

Eligibility Criteria

• Age: 18 Years - 30 Years
• Sex: female
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• Young healthy adults who scored either high or low on the Three factor eating questionnaire disinhibition subscale

You may not qualify if:

• Participants were excluded if they
• had a cardiovascular or metabolic disorder
• gastrointestinal problems
• were pregnant
• had a current diagnosis of a mood or eating disorder
• and/or were taking medications or herbal supplements to manage body weight or control appetite

Sponsors & Collaborators

• Swansea University: lead

Study Sites (1)

Swansea University

Swansea, West Glamorgan, SA2 8PP, United Kingdom

Location

Related Publications (1)

• Young HA, Watkins H. Eating disinhibition and vagal tone moderate the postprandial response to glycemic load: a randomised controlled trial. Sci Rep. 2016 Oct 20;6:35740. doi: 10.1038/srep35740.

  PMID: 27761024 DERIVED

MeSH Terms

Interventions

isomaltulose; Glucose

Intervention Hierarchy (Ancestors)

Hexoses; Monosaccharides; Sugars; Carbohydrates

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: DOUBLE
• Who Masked: PARTICIPANT, INVESTIGATOR
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Dr

Study Record Dates

• First Submitted: June 29, 2016
• First Posted: July 11, 2016
• Study Start: September 1, 2015
• Primary Completion: December 1, 2015
• Study Completion: December 1, 2015
• Last Updated: July 11, 2016

Record last verified: 2016-07

Locations

GB (1)