Cognitive Training in Obsessive Compulsive Disorder

NCT02818088 | Terminated

• 1 other identifier: S14/05/113
• Study Type: interventional
• Target: 9
• Locations: 1 country
• Sites: 1

Brief Summary

This unique study will allow us to observe the neural correlates associated with working memory in an obsessive compulsive disorder (OCD) paradigm. We believe that developing working memory in participants suffering with OCD will reduce the severity of their symptomology. This will allow a greater understanding into the functioning of these participants which in turn presents with treatment possibilities.

Conditions

Obsessive-Compulsive Disorder

Outcome Measures

Primary Outcomes (2)

• Yale-Brown Obsessive Compulsive Scale (YBOCS)

  Immediately after intervention

• Cambridge neuropsychological test automated battery (CANTAB)

  Immediately after intervention

Study Arms (1)

Cognitive Training

EXPERIMENTAL

Cognitive Training - n Back.

Behavioral: n-Back (Cognitive Training)

Interventions

n-Back (Cognitive Training) BEHAVIORAL

Cognitive Training

Eligibility Criteria

• Age: 18 Years - 65 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• A primary diagnosis of OCD, with a score \> 16 on the Yale-Brown Obsessive Compulsive Scale (YBOCS) (Goodman et al, 1989b, 1006-1011).
• Participants must be aged older than 18 and younger than 65 years.
• Right handed.
• If taking SSRI's the participant needs to be on a stable dose for at least 2 months.

You may not qualify if:

• Significant physical or neurological illnesses. An exception will be made for patients taking SSRI's (and not using any other drugs).
• Any significant current DSM disorder (in addition to OCD).
• Past history of significant substance or alcohol abuse.
• Pregnancy.
• Any metal pins/ prostheses or cardiac pacemakers.
• Sufferers of claustrophobia.
• Head injury

Sponsors & Collaborators

• University of Stellenbosch: lead
• University of Cape Town: collaborator

Study Sites (1)

Stellenbosch University

Cape Town, Western Cape, 7505, South Africa

Location

MeSH Terms

Conditions

Obsessive-Compulsive Disorder

Interventions

Cognitive Training

Condition Hierarchy (Ancestors)

Anxiety Disorders; Mental Disorders

Intervention Hierarchy (Ancestors)

Neurological Rehabilitation; Rehabilitation; Aftercare; Continuity of Patient Care; Patient Care; Therapeutics; Health Services; Health Care Facilities Workforce and Services

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Purpose: TREATMENT
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Professor Christine Lochner

Study Record Dates

• First Submitted: June 27, 2016
• First Posted: June 29, 2016
• Study Start: February 1, 2016
• Primary Completion: December 1, 2019
• Study Completion: December 1, 2019
• Last Updated: May 6, 2021

Record last verified: 2021-05

Data Sharing

• IPD Sharing: Will not share

Locations

ZA (1)