NCT02812472

Brief Summary

The purpose of this study was to investigate the effects of the treadmill training with functional electric stimulation on sensorimotor cortical reorganization and functional improvement in subjects with chronic stroke.

Trial Health

100
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
18

participants targeted

Target at below P25 for not_applicable stroke

Timeline
Completed

Started Aug 2008

Shorter than P25 for not_applicable stroke

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

August 1, 2008

Completed
4 months until next milestone

Primary Completion

Last participant's last visit for primary outcome

December 1, 2008

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

December 1, 2008

Completed
7.5 years until next milestone

First Submitted

Initial submission to the registry

June 15, 2016

Completed
9 days until next milestone

First Posted

Study publicly available on registry

June 24, 2016

Completed
Last Updated

June 24, 2016

Status Verified

June 1, 2016

Enrollment Period

4 months

First QC Date

June 15, 2016

Last Update Submit

June 21, 2016

Conditions

Outcome Measures

Primary Outcomes (4)

  • N1 latency of somatosensory evoked potential

    Change from baseline at 4 weeks

  • N1P1 amplitude of somatosensory evoked potential

    Change from baseline at 4 weeks

  • motor threshold of motor evoked potential

    Change from baseline at 4 weeks

  • map size of motor evoked potential

    Change from baseline at 4 weeks

Secondary Outcomes (5)

  • Fugl-Meyer Assessment

    Change from baseline at 4 weeks

  • Motricity Index

    Change from baseline at 4 weeks

  • Berg Balance Scale

    Change from baseline at 4 weeks

  • walking speed

    Change from baseline at 4 weeks

  • Modified-Emory Functional Ambulation Profile

    Change from baseline at 4 weeks

Study Arms (2)

treadmill training with functional electrical stimulation

EXPERIMENTAL

Subjects in the experimental group received additional treadmill training with functional electric stimulation for 25 minutes per session, followed by 5 minutes cool down for 12 sessions.

Other: Treadmill training with functional electrical stimulation

treadmill training without functional electrical stimulation

ACTIVE COMPARATOR

Subjects in the control group received additional treadmill training without functional electric stimulation for 25 minutes per session, followed by 5 minutes cool down for 12 sessions.

Other: Treadmill training without functional electrical stimulation

Interventions

treadmill training with functional electrical stimulation
treadmill training without functional electrical stimulation

Eligibility Criteria

Age40 Years - 82 Years
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • diagnosis of unilateral hemiparesis secondary to cerebrovascular accident with post-onset duration of more than 6 months
  • ability to walk independently for at least 6 meters with or without use of walking aids
  • ability to follow simple verbal commands or instructions

You may not qualify if:

  • unstable medical conditions
  • history of other diseases known to interfere with participation in the study
  • past history of a seizure
  • history of skin allergy to electrode
  • use of a cardiac pacemaker

Contact the study team to confirm eligibility.

Sponsors & Collaborators

MeSH Terms

Conditions

Stroke

Condition Hierarchy (Ancestors)

Cerebrovascular DisordersBrain DiseasesCentral Nervous System DiseasesNervous System DiseasesVascular DiseasesCardiovascular Diseases

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
NONE
Purpose
TREATMENT
Intervention Model
PARALLEL
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Professor

Study Record Dates

First Submitted

June 15, 2016

First Posted

June 24, 2016

Study Start

August 1, 2008

Primary Completion

December 1, 2008

Study Completion

December 1, 2008

Last Updated

June 24, 2016

Record last verified: 2016-06