Electrical Stimulation Combined With Motor Training on EEG-EMG Coherence and Motor Function in Individuals With Stroke
Effects of 8-week Sensory Electrical Stimulation Combined With Motor Training on EEG-EMG Coherence and Motor Function in Individuals With Stroke
1 other identifier
interventional
12
0 countries
N/A
Brief Summary
This study investigated whether electrical stimulation (ES) prior to a hand function training session for a total of eight weeks can better improve neuromuscular control and hand function in subacute stroke individuals and change electroencephalography-electromyography (EEG-EMG) coherence, as compared to the control (sham ES).
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at below P25 for not_applicable stroke
Started Aug 2013
Typical duration for not_applicable stroke
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
August 28, 2013
CompletedPrimary Completion
Last participant's last visit for primary outcome
January 4, 2017
CompletedStudy Completion
Last participant's last visit for all outcomes
January 4, 2017
CompletedFirst Submitted
Initial submission to the registry
September 5, 2017
CompletedFirst Posted
Study publicly available on registry
September 11, 2017
CompletedSeptember 11, 2017
September 1, 2017
3.4 years
September 5, 2017
September 6, 2017
Conditions
Keywords
Outcome Measures
Primary Outcomes (2)
Fugl-Meyer Assessment for Upper Extremity
evaluate changes in upper extremity function of the stroke subjects
before intervention, four weeks after, at the end of the eight-week intervention and four weeks after the intervention period ended
EEG-EMG coherence
evaluate changes in functional connectivity between motor cortex and active muscles
before intervention, four weeks after, at the end of the eight-week intervention and four weeks after the intervention period ended
Study Arms (2)
Electrical stimulation
EXPERIMENTALControl
SHAM COMPARATORInterventions
sensory electrical stimulation was applied prior to upper limb functional training
electrodes were placed on the same location as the Electrical stimulation condition, but no electric current was applied
Eligibility Criteria
You may qualify if:
- first-ever cerebral cortical region involved chronic stroke, onset over a month,
- able to perform active thumb flexion on the affected side with the scores of manual muscle test at least two points, and
- at stable medical condition for intervention
You may not qualify if:
- history of other neurological disorders,
- cognitive impairment (Mini-Mental State Examination score \<24, MMSE),26
- unable to follow orders,
- contraindications of ES, and
- under 20 years old
Contact the study team to confirm eligibility.
Sponsors & Collaborators
MeSH Terms
Conditions
Interventions
Condition Hierarchy (Ancestors)
Intervention Hierarchy (Ancestors)
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- RANDOMIZED
- Masking
- SINGLE
- Who Masked
- PARTICIPANT
- Purpose
- OTHER
- Intervention Model
- PARALLEL
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Associate professor
Study Record Dates
First Submitted
September 5, 2017
First Posted
September 11, 2017
Study Start
August 28, 2013
Primary Completion
January 4, 2017
Study Completion
January 4, 2017
Last Updated
September 11, 2017
Record last verified: 2017-09