The Acute Effect of Two Berry Extracts on Cognition and Mood in Adults Aged 40 to 60

NCT02810769 | Completed DMC

• 1 other identifier: 28AI5
• Study Type: interventional
• Target: 36
• Locations: 1 country
• Sites: 1

Brief Summary

The first study of my PhD showed that acute supplementation of berry extracts can modulate cognitive behaviour in healthy adults. There is a growing body of evidence supporting an improvement in memory and learning performance in animal models following the ingestion of flavonoid rich fruits (Shukitt-Hale et al 2008;Spencer 2008; Spencer et al., 2008). However, study 2, showed no effect on any aspects of memory in healthy young adults after supplementation of the berry extracts. It is hypothesised that the lack of behavioural effects on memory of the berry juice in study 2 was because of the cohort used. These healthy adult participants were already performing near to their peak (Salthouse et al., 2009), and unlike study one, participants were not mentally fatigued enough to reveal subtle cognitive benefits. The aims of the study are to examine if acute supplementation of two berry extracts in an older population can augment memory, attention and executive function. Secondly, the time course of these behavioural effects will be measured by multiple cognitive assessments throughout the day after consumption of the extracts.

Conditions

Ageing

Outcome Measures

Primary Outcomes (5)

• Blood glucose

  Change from baseline at 60, 140, 180, 200, 230 and 350 minutes post dose

• Blood lactate

  Change from baseline at 60, 140, 180, 200, 230 and 350 minutes post dose

• Monoamine oxidase B inhibition

  Change from baseline at 350 minutes post dose

• Cognitive Measures - Memory- Assessed using a computerised cognitive batter.

  Change from baseline 60, 150, 240 and 360 minutes post dose

• Cognitive Measures - Attention- Assessed using a computerised cognitive batter.

  Change from baseline 60, 150, 240 and 360 minutes post dose

Study Arms (3)

Control

PLACEBO COMPARATOR

Sugar matched control containing no phytochemicals

Dietary Supplement: Control

Juiced berry drink

EXPERIMENTAL

Cold pressed berry drink standardised to contain 500mg of berry polyphenols

Dietary Supplement: Berry drink

Powdered berry drink

EXPERIMENTAL

Berry drink made up from a powdered concentrate. each drink will be standardised to contain 500mg of polyphenols

Dietary Supplement: Powdered berry drink

Interventions

Berry drink DIETARY_SUPPLEMENT

Cold pressed berry drink standardised to contain 500mg of berry polyphenols

Juiced berry drink

Control DIETARY_SUPPLEMENT

Sugar matched control containing berry flavouring and no phytochemicals

Control

Powdered berry drink DIETARY_SUPPLEMENT

Berry drink made from a powder concentrate standardised to contain 500mg of polyphenols

Powdered berry drink

Eligibility Criteria

• Age: 40 Years - 60 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• Healthy
• Non-smokers
• Aged between 40 and 60 years

You may not qualify if:

• History of neurological, vascular or psychiatric illness.
• BMI greater than 35 kg/m2
• Current diagnosis of depression and/or anxiety.
• History or current diagnosis of drug/alcohol abuse.
• Anaemia.
• Any heart disorder.
• Hypertension
• Any respiratory disorder.
• Diabetes.
• Food intolerances/sensitivities.
• Phenylketonuria.
• Use tobacco products or have ceased in the last 6 months.
• Currently taking, or have taken in the last 2 weeks, any prescribed, illicit or herbal drugs and food supplements.
• Any known active infections.
• HIV antibody positive.

Sponsors & Collaborators

• Northumbria University: lead
• The New Zealand Institute of Plant and Food Research Ltd.: collaborator

Study Sites (1)

Brain, Performance and Nutrition Research Centre

Newcastle upon Tyne, Newcastle Upon-Tyne, NE18ST, United Kingdom

Location

Related Links

• Related Info

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: TRIPLE
• Who Masked: PARTICIPANT, INVESTIGATOR, OUTCOMES ASSESSOR
• Purpose: BASIC SCIENCE
• Intervention Model: CROSSOVER
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principal Investigator

Study Record Dates

• First Submitted: November 8, 2012
• First Posted: June 23, 2016
• Study Start: November 1, 2012
• Primary Completion: May 1, 2013
• Study Completion: May 1, 2013
• Last Updated: June 23, 2016

Record last verified: 2016-06

Locations

GB (1)