Attention and Memory Training With Video Games in Old Age

NCT02796508 | Completed DMC

• 1 other identifier: PSI2013-41409R
• Study Type: interventional
• Target: 75
• Locations: 1 country
• Sites: 1

Brief Summary

Neuroplasticity-based approaches seem very promising to maintain cognitive health in older adults and postpone the onset of cognitive-decline and dementia symptoms. The aims of this project are threefold:

1. 1.the evaluation of the effects of a neuroplasticity-based-cognitive randomized computer-based intervention consisting in training with non-action video games on brain and cognitive functions that decline with ageing, including attention and spatial working memory (WM), in older adults using behavioral measures and electrophysiological recordings (event-related potentials -ERPs- and event-related spectral perturbations -ERSPs);
2. 2.the study of the effects of age and 3 months maintenance on the cognitive and neural signatures of transfer effects to attentional and spatial WM tasks; and
3. 3.to investigate the neuroinflammatory mechanisms assessed by non-invasive methods in saliva from participants underlying cognitive training-induced effects.

Conditions

Ageing

Keywords

Healthy aging; Cognitive training; Video-games; Attention; Working memory; Wellbeing

Outcome Measures

Primary Outcomes (4)

• STROOP-Negative Priming

  Participants with non-action video-game training, change from baseline in selective attention and capacity to inhibit information on Stroop-Negative Priming task at 15 weeks and maintenance at 30 weeks

  Change from Baseline Stroop-Negative Priming task at 15 weeks and 30 weeks

• ODDBALL

  Participants with non-action video-game training, change from baseline in alertness and distraction on Oddball task at 15 weeks and maintenance at 30 weeks

  Change from Baseline oddball task at 15 weeks and 30 weeks

• N-BACK

  Participants with non-action video-game training, change from baseline in working memory on N-back task at 15 weeks and maintenance at 30 weeks

  Change from Baseline N-back task at 15 weeks and 30 weeks

• CORSI BLOCK

  Participants with video-game training, change from baseline in spatial working memory on Corsi block task after at 15 weeks and maintenance at 30 weeks

  Participants with non-action video-game training, change from baseline Corsi block task at 15 weeks and 30 weeks

Secondary Outcomes (2)

• Improvement of the performance (accuracy scores) obtained on the non-action video games (experimental group) and the non-cognitive video games (active comparator) comparing accuracy scores of the first to the last training session.

  Change from the first training session to the last (16th) training session, up to 12 weeks

• Level of motivation assessed with a questionnaire

  Maintenance during the 16 training sessions of non-action cognitive video game training and non-cognitive training at first session, 8th and 16th training sessions. Up to 12 weeks.

Study Arms (2)

Non-action video game training

EXPERIMENTAL

Experimental: Non-action video game training 16 1-hour training sessions with 10 non-action video game training selected games from Lumosity.

Behavioral: Experimental: Non-action video game training

Non-cognitive video game training

ACTIVE COMPARATOR

Active Control: Non-cognitive social video game training 16 1-hour training sessions with non-cognitive video game training with social games from The Sims.

Behavioral: Active Comparator: Non-cognitive video game training

Interventions

Experimental: Non-action video game training BEHAVIORAL

PSI2013-41409R. Effects of video game training on behavioral and neuroimaging measures of attention and memory

Also known as: 16 training session with Lumosity over 8-10 weeks in small groups

Non-action video game training

Active Comparator: Non-cognitive video game training BEHAVIORAL

16 training sessions with The Sims over 8-10 weeks in small groups

Also known as: Social video game training

Non-cognitive video game training

Eligibility Criteria

• Age: 55 Years - 84 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Mini-Mental State Examination (MMSE) score 26 or greater
• Global Deterioration Scale (GDS) score less than 5
• Independent living
• Normal or correct to normal vision and hearing

You may not qualify if:

• Diagnosis of dementia
• Planned move from study area
• Inability to complete study activities
• Communication problems.

Sponsors & Collaborators

• Universidad Nacional de Educación a Distancia: lead

Study Sites (1)

Department of Basic Psychology II (UNED)

Madrid, 28040, Spain

Location

Related Publications (2)

• Ballesteros S, Mayas J, Ruiz-Marquez E, Prieto A, Toril P, Ponce de Leon L, de Ceballos ML, Reales Aviles JM. Effects of Video Game Training on Behavioral and Electrophysiological Measures of Attention and Memory: Protocol for a Randomized Controlled Trial. JMIR Res Protoc. 2017 Jan 24;6(1):e8. doi: 10.2196/resprot.6570.

  PMID: 28119279 RESULT

• Ballesteros S, Mayas J, Prieto A, Ruiz-Marquez E, Toril P, Reales JM. Effects of Video Game Training on Measures of Selective Attention and Working Memory in Older Adults: Results from a Randomized Controlled Trial. Front Aging Neurosci. 2017 Nov 1;9:354. doi: 10.3389/fnagi.2017.00354. eCollection 2017.

  PMID: 29163136 DERIVED

Study Officials

• Soledad Ballesteros, Ph.D.

  Departament of Basic Psychology II, Universidad Nacional de Educación a Distancia (UNED)

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: PARTICIPANT
• Purpose: PREVENTION
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Professor

Study Record Dates

• First Submitted: May 12, 2016
• First Posted: June 10, 2016
• Study Start: September 1, 2015
• Primary Completion: September 30, 2017
• Study Completion: September 30, 2017
• Last Updated: October 30, 2017

Record last verified: 2017-10

Locations

ES (1)