Generation 100: Blood Volume and Cardiac Function in Healthy Aging

NCT01765816 | Completed DMC

• 1 other identifier: Gen-100-sub1
• Study Type: interventional
• Target: 25
• Locations: 1 country
• Sites: 1

Brief Summary

Hypothesis: Exercise will reduce morbidity and mortality rates in an elderly population. The extent of reduction will be intensity dependent. As part of the "Generation 100" study, this sub-study project will investigate the effect of exercise on blood volume, cardiopulmonary health and heart function in healthy aging. Objective is to determine the acute effect of one endurance training session on blood volume in healthy elderly. The working hypothesis is that one interval training session increases total blood volume by 10% in healthy elderly, and that there will be no change after moderate continuous training.

Conditions

Ageing

Keywords

Exercise; Elderly; Blood volume; Hemoglobin

Outcome Measures

Primary Outcomes (1)

• total blood volume

  carbon monoxide-rebreathing spirometry (Bayreuth, Germany)

  24 hours

Secondary Outcomes (1)

• hemoglobin volume

  24 hours

Study Arms (2)

high intensity interval training

EXPERIMENTAL

one interval training session with 1 x 4 and 4 x 4 minutes interval training at 90-95% of peak heart rate

Behavioral: high intensity interval training; Behavioral: moderate intensity training

moderate intensity training

ACTIVE COMPARATOR

45 minutes of moderate continuous training at 75% of maximal heart rate

Behavioral: high intensity interval training; Behavioral: moderate intensity training

Interventions

high intensity interval training BEHAVIORAL

high intensity interval training; moderate intensity training

moderate intensity training BEHAVIORAL

high intensity interval training; moderate intensity training

Eligibility Criteria

• Age: 70 Years - 75 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Older Adult (65+)

You may qualify if:

• ability to walk at least 1km,
• born in 1938,1939,1940,1941 or 1942
• Sufficiently good health to be able to take part in the study, as determined by the researchers

You may not qualify if:

• Illness or disability that precludes exercise or hinders completion of the study
• Uncontrolled hypertension
• Symptomatic valve disease, hyper tropic cardio-myopathy or unstable angina
• Active cancer
• Test results indicating that study participation is unsafe

Sponsors & Collaborators

• Norwegian University of Science and Technology: lead

Study Sites (1)

Norwegian University of Science and Technology

Trondheim, 7006, Norway

Location

Related Links

• Generation 100 web page

MeSH Terms

Conditions

Motor Activity

Interventions

High-Intensity Interval Training

Condition Hierarchy (Ancestors)

Behavior

Intervention Hierarchy (Ancestors)

Physical Conditioning, Human; Exercise; Motor Activity; Movement; Musculoskeletal Physiological Phenomena; Musculoskeletal and Neural Physiological Phenomena

Study Officials

• Ulrik Wisløff, Professor

  Norwegian University of Science and Technology

  STUDY CHAIR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: HEALTH SERVICES RESEARCH
• Intervention Model: CROSSOVER
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: January 8, 2013
• First Posted: January 10, 2013
• Study Start: August 1, 2012
• Primary Completion: February 1, 2014
• Study Completion: November 1, 2014
• Last Updated: September 28, 2020

Record last verified: 2020-09

Locations

NO (1)