High-intensity Interval Training Enhances Mobilization/Functionality of Endothelial Progenitor Cells and Depressed Shedding of Vascular Endothelial Cells Undergoing Hypoxia

NCT02802462 | Completed

• 1 other identifier: 101-0408A3
• Study Type: interventional
• Target: 60
• Locations: 0 countries
• Sites: N/A

Brief Summary

Exercise training improves endothelium-dependent vasodilation, whereas hypoxic stress causes vascular endothelial dysfunction. Monocyte- derived endothelial progenitor cells (Mon-EPCs) contribute to vascular repair process by differentiating into endothelial cells. This study investigates how high-intensity interval (HIT) and moderate intensity-continuous (MCT) exercise training affect circulating Mon-EPC levels and EPC functionality under hypoxic condition. Sixty healthy sedentary males were randomized to engage either HIT (3-minute intervals at 40% and 80%VO2max , n=20) or MCT (sustained 60%VO2max , n=20) for 30 minutes/day, 5 days/week for 6 weeks, or to a control group that did not received exercise intervention (n=20). Mon-EPC characteristics and EPC functionality under hypoxic exercise (HE, 100W under 12%O 2 ) were determined before and after various interventions.

Conditions

Hypoxia

Keywords

endothelial progenitor cell; hemodynamic; Exercise; HIIT

Outcome Measures

Primary Outcomes (1)

• Circulating progenitor cells conten

  by flow cytometry before and after rehabilitation circulating progenitor cells conten before and after hypoxic exercise test

  6 weeks

Secondary Outcomes (1)

• Cardiopulmonary fitness

  6 weeks

Other Outcomes (3)

• Cardiac hemodynamic measurement

  6 weeks

• Cerebral hemodynamic measurement

  6 weeks

• Muscular hemodynamic measurement

  6 weeks

Study Arms (3)

High intensity-interval (HIT)

EXPERIMENTAL

Behavioral: HIT

moderate intensity-continuous (MCT)

EXPERIMENTAL

Behavioral: MCT

control (CTL)

NO INTERVENTION

Interventions

HIT BEHAVIORAL

3-minute intervals at 40% and 80%VO 2max

High intensity-interval (HIT)

MCT BEHAVIORAL

sustained 60%VO 2max

moderate intensity-continuous (MCT)

Eligibility Criteria

• Age: 20 Years - 28 Years
• Sex: male
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• Sedentary life
• Age 20\~28

You may not qualify if:

• Smokers
• Users of medication/vitamins
• Any cardiopulmonary/hematological risk
• Regular exercise habits at least 1 year
• Exposed to high altitudes (\>3000 m) for at least 1 year

Sponsors & Collaborators

• Chang Gung Memorial Hospital: lead

MeSH Terms

Conditions

Hypoxia; Motor Activity

Condition Hierarchy (Ancestors)

Signs and Symptoms, Respiratory; Signs and Symptoms; Pathological Conditions, Signs and Symptoms; Behavior

Study Officials

• Jong-Shyan Wang, PhD

  Chang Gung Memorial Hospital

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: HEALTH SERVICES RESEARCH
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: PhD, Rehabilitation Science

Study Record Dates

• First Submitted: May 19, 2016
• First Posted: June 16, 2016
• Study Start: December 1, 2012
• Primary Completion: December 1, 2013
• Study Completion: December 1, 2013
• Last Updated: June 16, 2016

Record last verified: 2016-06