NCT01627652

Brief Summary

This scientific study aims at studying human adaptations to high altitude and the studies will be conducted at the University of Zürich and during a 4 week high altitude "expedition" to the Jungfraujoch research station at 3450 m altitude. The proposal is made up of several independent biological research projects to be conducted in the same healthy volunteers participating in the study. Thus, the subjects will be studied at sea level, and then during 4 weeks of acclimatization to high altitude, and for some experimental purposes all subjects will also be studied one and two weeks after return to sea level.

Trial Health

43
At Risk

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Trial has exceeded expected completion date
Enrollment
8

participants targeted

Target at below P25 for not_applicable

Timeline
Completed

Started Apr 2012

Shorter than P25 for not_applicable

Geographic Reach
1 country

1 active site

Status
unknown

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

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Study Timeline

Key milestones and dates

Study Start

First participant enrolled

April 1, 2012

Completed
1 month until next milestone

First Submitted

Initial submission to the registry

May 4, 2012

Completed
2 months until next milestone

First Posted

Study publicly available on registry

June 26, 2012

Completed
5 days until next milestone

Primary Completion

Last participant's last visit for primary outcome

July 1, 2012

Completed
2 months until next milestone

Study Completion

Last participant's last visit for all outcomes

September 1, 2012

Completed
Last Updated

June 26, 2012

Status Verified

June 1, 2012

Enrollment Period

3 months

First QC Date

May 4, 2012

Last Update Submit

June 21, 2012

Conditions

Hypoxia

Keywords

hypoxia

Outcome Measures

Primary Outcomes (1)

  • Human adaptation to high altitude

    The primary outcome measure are changes in red cell blood mass, cardiac output, middle cerebral blood flow, muscle sympathetic activity and mitochondrial function.

    May-June, 2012

Study Arms (1)

altitude

EXPERIMENTAL

subjects will be studies at sea level and at high altitude

Other: altitude

Interventions

altitudeOTHER

the subjects will live one month at 3450 m altitude in the Jungfraujoch Research Station

Also known as: Jungfraujoch Research Station
altitude

Eligibility Criteria

Age18 Years - 35 Years
Sexmale
Healthy VolunteersYes
Age GroupsAdult (18-64)

You may qualify if:

  • to 35 yrs of age
  • male
  • healthy

You may not qualify if:

  • smokers

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

University of Zürich and the JUngfraujoch Research Station

Zürich and Jungfraujoch (mountain), 8057, Switzerland

RECRUITING

MeSH Terms

Conditions

Hypoxia

Interventions

Altitude

Condition Hierarchy (Ancestors)

Signs and Symptoms, RespiratorySigns and SymptomsPathological Conditions, Signs and Symptoms

Intervention Hierarchy (Ancestors)

EnvironmentEcological and Environmental PhenomenaBiological PhenomenaEnvironment and Public Health

Central Study Contacts

Carsten Lundby, PhD

CONTACT

0041446355052carsten.lundby@access.uzh.ch

Study Design

Study Type
interventional
Phase
not applicable
Allocation
NA
Masking
NONE
Purpose
BASIC SCIENCE
Intervention Model
SINGLE GROUP
Sponsor Type
OTHER
Responsible Party
SPONSOR

Study Record Dates

First Submitted

May 4, 2012

First Posted

June 26, 2012

Study Start

April 1, 2012

Primary Completion

July 1, 2012

Study Completion

September 1, 2012

Last Updated

June 26, 2012

Record last verified: 2012-06

Locations

CH(1)