Effect of Hypoxic Exposure on Blood Variables in Elite Wrestlers

NCT06373562 | Completed

• 1 other identifier: Wrestlers LH-TL
• Study Type: interventional
• Target: 12
• Locations: 0 countries
• Sites: N/A

Brief Summary

Twelve male wrestlers of the National Polish Team were observed in the study during the camp. The hypoxia group (n=6) participated in sports training and hypoxic exposure, while the control group (n=6) included wrestlers participating only in sports training. The hypoxic group lived and slept in hypoxic rooms. During the camp, all wrestlers followed the same training schedule and diet. In the blood were determined levels of creatine kinase (CK), C-reactive protein (hsCRP) concentration, nitric oxide (NO), morphology, reticulocytes, lipid profile, and ferritin. Also vascular endothelial growth factor (VEGF, VEGFR2, and VEGFR3), erythropoietin (EPO), angiopoietin (Ang 1, Ang 2), endothelial cell adhesion factor-1 (VCAM-1), Erythropoietin (EPO) and hypoxia-inducible factor 1 (HIF-1). Body weight composition was determined.

Conditions

Hypoxia

Keywords

hypoxia; EPO; wrestlers; HIF-1; athletes

Outcome Measures

Primary Outcomes (7)

• CK

  creatine kinase

  The blood was taken at the beginning of the camp (baseline), after 6 days, after 15 days.

• hsCRP

  reactive C-protein

  The blood was taken at the beginning of the camp (baseline), after 6 days, after 15 days.

• HIF-1

  hypoxia-inducible factor 1

  The blood was taken at the beginning of the camp (baseline), after 6 days, after 15 days.

• EPO

  Erythropoietin

  The blood was taken at the beginning of the camp (baseline), after 6 days, after 15 days.

• VEGF, VEGF 2, VEGF 3.

  vascular endothelial growth factor

  The blood was taken at the beginning of the camp (baseline), after 6 days, after 15 days.

• Ang 1, Ang 2

  angiopoietin

  The blood was taken at the beginning of the camp (baseline), after 6 days, after 15 days.

• VCAM-1

  endothelial cell adhesion factor-1

  The blood was taken at the beginning of the camp (baseline), after 6 days, after 15 days.

Study Arms (2)

Hypoxia

EXPERIMENTAL

Live High-Train Low method was used.

Other: hypoxia

Control group

NO INTERVENTION

The control group was participating in the same training protocol.

Interventions

hypoxia OTHER

The athletes were living in hypoxic rooms, which could simulate a selected altitude above sea level.

Hypoxia

Eligibility Criteria

• Sex: male
• Healthy Volunteers: Yes
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)

You may qualify if:

• member of national wrestler's teams, and sports camp participant.

You may not qualify if:

• negative symptoms of hypoxia, and/or injury.

Sponsors & Collaborators

• Poznan University of Physical Education: lead

Related Publications (4)

• Kasperska A, Zembron-Lacny A. The effect of intermittent hypoxic exposure on erythropoietic response and hematological variables in elite athletes. Physiol Res. 2020 Apr 30;69(2):283-290. doi: 10.33549/physiolres.934316. Epub 2020 Mar 23.

  PMID: 32199016 BACKGROUND

• Czuba M, Fidos-Czuba O, Ploszczyca K, Zajac A, Langfort J. Comparison of the effect of intermittent hypoxic training vs. the live high, train low strategy on aerobic capacity and sports performance in cyclists in normoxia. Biol Sport. 2018 Mar;35(1):39-48. doi: 10.5114/biolsport.2018.70750. Epub 2017 Oct 11.

  PMID: 30237660 BACKGROUND

• Wilber RL. Application of altitude/hypoxic training by elite athletes. Med Sci Sports Exerc. 2007 Sep;39(9):1610-24. doi: 10.1249/mss.0b013e3180de49e6.

  PMID: 17805095 BACKGROUND

• Li J, Li Y, Atakan MM, Kuang J, Hu Y, Bishop DJ, Yan X. The Molecular Adaptive Responses of Skeletal Muscle to High-Intensity Exercise/Training and Hypoxia. Antioxidants (Basel). 2020 Jul 24;9(8):656. doi: 10.3390/antiox9080656.

  PMID: 32722013 BACKGROUND

MeSH Terms

Conditions

Hypoxia

Condition Hierarchy (Ancestors)

Signs and Symptoms, Respiratory; Signs and Symptoms; Pathological Conditions, Signs and Symptoms

Study Officials

• Anna Kasperska

  Poznań University of Physical Education, Faculty of Sport Sciences in Gorzów Wielkopolski, Poland;

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: DIAGNOSTIC
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Model Details: Wrestlers in H group were living in hypoxic rooms for 8-14h/d and between that they were participating in sports training. C group was participating in the same training protocol.

Study Record Dates

• First Submitted: April 12, 2024
• First Posted: April 18, 2024
• Study Start: December 2, 2013
• Primary Completion: December 18, 2013
• Study Completion: December 18, 2013
• Last Updated: January 17, 2025

Record last verified: 2024-04

Data Sharing

• IPD Sharing: Will not share