NCT02799134

Brief Summary

CAR is short for cortisol awakening response. The neural mechanism of CAR effect on high-order cognition and social cognition is less known...

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
67

participants targeted

Target at P50-P75 for not_applicable healthy

Timeline
Completed

Started Nov 2015

Typical duration for not_applicable healthy

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

November 1, 2015

Completed
5 months until next milestone

First Submitted

Initial submission to the registry

April 6, 2016

Completed
2 months until next milestone

First Posted

Study publicly available on registry

June 14, 2016

Completed
10 months until next milestone

Primary Completion

Last participant's last visit for primary outcome

April 10, 2017

Completed
20 days until next milestone

Study Completion

Last participant's last visit for all outcomes

April 30, 2017

Completed
Last Updated

April 22, 2022

Status Verified

April 1, 2022

Enrollment Period

1.4 years

First QC Date

April 6, 2016

Last Update Submit

April 21, 2022

Conditions

Healthy

Keywords

Cortisol Awakening Response suppressionDexamethasone Suppression Testhigh-order cognitionsocial cognition

Outcome Measures

Primary Outcomes (1)

  • Cortisol Awakening Response Level(nmol/L) after Taking Dexamethasone

    The dosage of Dexamethasone is 0.5mg.

    one year

Study Arms (3)

group1

EXPERIMENTAL

take Dexamethasone at 22:00 on the first day, 0.5mg

Drug: Dexamethasone

group2

PLACEBO COMPARATOR

take Vitamin C at 22:00 on the first day, 0.5mg

Drug: Vitamin C

group3

OTHER

take Dexamethasone at 15:00 on the second day, 0.5mg

Drug: Dexamethasone

Interventions

DexamethasoneDRUG
group1group3
Vitamin CDRUG
group2

Eligibility Criteria

Age18 Years - 26 Years
Sexmale
Healthy VolunteersYes
Age GroupsAdult (18-64)

You may qualify if:

  • Healthy college students.

You may not qualify if:

  • Current or history of psychiatric or neurological illness.
  • Current use of any medications.

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Beijing Normal University

Beijing, Beijing Municipality, 100875, China

Location

MeSH Terms

Interventions

DexamethasoneAscorbic Acid

Intervention Hierarchy (Ancestors)

PregnadienetriolsPregnadienesPregnanesSteroidsFused-Ring CompoundsPolycyclic CompoundsSteroids, FluorinatedSugar AcidsAcids, AcyclicCarboxylic AcidsOrganic ChemicalsHydroxy AcidsCarbohydrates

Study Officials

  • Shaozheng Qin, Doctor

    Beijing Normal University

    STUDY CHAIR

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
TRIPLE
Who Masked
PARTICIPANT, CARE PROVIDER, INVESTIGATOR
Purpose
BASIC SCIENCE
Intervention Model
FACTORIAL
Sponsor Type
OTHER
Responsible Party
SPONSOR INVESTIGATOR
PI Title
Professor

Study Record Dates

First Submitted

April 6, 2016

First Posted

June 14, 2016

Study Start

November 1, 2015

Primary Completion

April 10, 2017

Study Completion

April 30, 2017

Last Updated

April 22, 2022

Record last verified: 2022-04

Locations

CN(1)