Acute Metabolic and Endocrine Responses of Glucose and Fructose in Healthy Young Subjects
1 other identifier
interventional
20
1 country
1
Brief Summary
The purpose of this study is to investigate the metabolic and endocrine responses during 3 hour after taking 75g fructose or glucose in young Chinese.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P25-P50 for not_applicable healthy
Started Mar 2015
Shorter than P25 for not_applicable healthy
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
March 1, 2015
CompletedPrimary Completion
Last participant's last visit for primary outcome
June 1, 2015
CompletedStudy Completion
Last participant's last visit for all outcomes
June 1, 2015
CompletedFirst Submitted
Initial submission to the registry
October 25, 2015
CompletedFirst Posted
Study publicly available on registry
October 29, 2015
CompletedOctober 29, 2015
October 1, 2015
3 months
October 25, 2015
October 28, 2015
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
serum uric acid
Serum uric acid concentration was analyzed on HITACHI 7020 chemistry analyzer using enzyme-based colorimetric test or colorimetric test supplied by DiaSys Diagnostic Systems (Shanghai) Co., Ltd
3 hours
Secondary Outcomes (1)
blood pressure
3 hours
Other Outcomes (11)
serum glucose
3 hours
nitric oxide
3 hours
aldose reductase
3 hours
- +8 more other outcomes
Study Arms (2)
group fructose
EXPERIMENTALVolunteer was randomized into either group fructose or glucose
group glucose
EXPERIMENTALAfter one-week washout period, volunteer was crossed over for either group glucose or fructose.
Interventions
75g fructose is dissolved in 300 ml water.After overnight fasting, 300ml of solution at 0830 within 5 minutes is taken by volunteers
75g glucose is dissolved in 300 ml water.After overnight fasting, 300ml of solution at 0830 within 5 minutes is taken by volunteers
Eligibility Criteria
You may not qualify if:
- Subjects pregnant or having a history of hepatic or renal disease, fructose intolerance, gout, hypoglycemia, or diabetes mellitus were excluded.
- Subjects taking any drugs, botanicals, or nutraceutical known to influence blood pressure also were rejected either.
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
Zhejiang university
Hangzhou, Zhejiang, 310000, China
Related Publications (2)
Fulgoni V 3rd. High-fructose corn syrup: everything you wanted to know, but were afraid to ask. Am J Clin Nutr. 2008 Dec;88(6):1715S. doi: 10.3945/ajcn.2008.25825A.
PMID: 19064535BACKGROUNDLe MT, Frye RF, Rivard CJ, Cheng J, McFann KK, Segal MS, Johnson RJ, Johnson JA. Effects of high-fructose corn syrup and sucrose on the pharmacokinetics of fructose and acute metabolic and hemodynamic responses in healthy subjects. Metabolism. 2012 May;61(5):641-51. doi: 10.1016/j.metabol.2011.09.013. Epub 2011 Dec 5.
PMID: 22152650BACKGROUND
MeSH Terms
Interventions
Intervention Hierarchy (Ancestors)
Study Officials
- STUDY DIRECTOR
Duo Li, Doctor
College of Biosystem Engineering & Food Science, Zhejiang University
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- RANDOMIZED
- Masking
- TRIPLE
- Who Masked
- PARTICIPANT, CARE PROVIDER, INVESTIGATOR
- Purpose
- PREVENTION
- Intervention Model
- CROSSOVER
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Professor
Study Record Dates
First Submitted
October 25, 2015
First Posted
October 29, 2015
Study Start
March 1, 2015
Primary Completion
June 1, 2015
Study Completion
June 1, 2015
Last Updated
October 29, 2015
Record last verified: 2015-10