Trait Anxiety and Defensive Networks
Trait Anxiety Modulates Resting State Functional Connectivity of Defensive Networks
1 other identifier
interventional
131
1 country
1
Brief Summary
to examine the association between trait and defensive network connectivity and the modulatory effect of oxytocin on it
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for not_applicable healthy
Started Dec 2015
Longer than P75 for not_applicable healthy
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
December 8, 2015
CompletedFirst Submitted
Initial submission to the registry
February 8, 2016
CompletedFirst Posted
Study publicly available on registry
February 17, 2016
CompletedPrimary Completion
Last participant's last visit for primary outcome
August 19, 2021
CompletedStudy Completion
Last participant's last visit for all outcomes
November 20, 2021
CompletedFebruary 11, 2022
February 1, 2022
5.7 years
February 8, 2016
February 10, 2022
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
the resting state functional connectivity changes in the defensive network
The resting-state activity can be accessed using functional magnetic resonance imaging (fMRI) by measuring spontaneous and low-frequency fluctuations (\< 0.1 Hz) when the brain is at rest. Group differences will be calculated in the high trait anxiety group relative to the low trait anxiety group and in the oxytocin group relative to the placebo group.
one day
Study Arms (4)
high trait anxiety group
EXPERIMENTALexperiment 1: identified according to scores of the trait anxiety scale.
low trait anxiety group
EXPERIMENTALexperiment 1: identified according to scores of the trait anxiety scale.
oxytocin group
EXPERIMENTALexperiment 2: intranasal administration of oxytocin
placebo control group
PLACEBO COMPARATORexperiment 2: intranasal administration of placebo
Interventions
splitting subjects into 2 groups according to scores of the trait anxiety scale
Eligibility Criteria
You may qualify if:
- Healthy subjects without past or current psychiatric or neurological disorders
You may not qualify if:
- females should not be pregnant or during menstruation.
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
school of life science and technology, University of Electronic Science and Technology of China
Chengdu, Sichuan, 610054, China
MeSH Terms
Interventions
Intervention Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Keith Kendrick, Dr.
University of Electronic Science and Technology of China
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- RANDOMIZED
- Masking
- DOUBLE
- Who Masked
- PARTICIPANT, INVESTIGATOR
- Purpose
- BASIC SCIENCE
- Intervention Model
- PARALLEL
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Prof.
Study Record Dates
First Submitted
February 8, 2016
First Posted
February 17, 2016
Study Start
December 8, 2015
Primary Completion
August 19, 2021
Study Completion
November 20, 2021
Last Updated
February 11, 2022
Record last verified: 2022-02