Association of Midlife Dietary and Lifestyle Factors on Cardiac Functional Changes in the Elderly
CardiacAging
1 other identifier
observational
800
1 country
1
Brief Summary
The investigators aim to investigate the association of midlife dietary and lifestyle factors on cardiac functional changes in the elderly. The investigators hypothesize that even in those without clinically manifest cardiovascular disease, the extent of underlying abnormalities in cardiovascular structure and function in the elderly would be independently related to midlife dietary and lifestyle factors.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for all trials
Started Jul 2014
Typical duration for all trials
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
Click on a node to explore related trials.
Study Timeline
Key milestones and dates
Study Start
First participant enrolled
July 1, 2014
CompletedFirst Submitted
Initial submission to the registry
May 31, 2016
CompletedFirst Posted
Study publicly available on registry
June 6, 2016
CompletedPrimary Completion
Last participant's last visit for primary outcome
April 1, 2017
CompletedStudy Completion
Last participant's last visit for all outcomes
April 1, 2017
CompletedJune 16, 2016
May 1, 2016
2.8 years
May 31, 2016
June 14, 2016
Conditions
Outcome Measures
Primary Outcomes (1)
First occurrence of cardiovascular event
1 Year
Study Arms (2)
Control
Healthy Volunteers will undergo the following studying procedures: Cardiovascular Magnetic Resonance Imaging (CMRI) Echocardiography Tonometry Genetic Testing (Blood) Hand-Grip Strength Measurement Body Fat Mass Analysis
Ageing
Ageing cohort will undergo the following studying procedures: Cardiovascular Magnetic Resonance Imaging (CMRI) Echocardiography Tonometry Genetic Testing (Blood) Body Fat Mass Analysis
Interventions
Cardiovascular MRI uses interaction of the magnetic properties of body tissues with strong magnetic fields to create heart images.
To measure heart chamber size, heart function, blood vessel size and blood vessel function. These measurements will help us understand the type and severity of heart failure.
The blood will be stored for genetic tests and development of cell lines to study genetic risks for aging related diseases and cardiovascular disease.
We will measure your hand grip strength using a standard hand dynamometer which is a portable meter that you will use your hands to press on.
Body composition will be analysed by a body composition analyser machine onto which you will have to stand on.
Eligibility Criteria
600 ageing participants randomly chosen from a current pool of about 5290 surviving cohort participants in the Singapore Chinese Health Study will be recruited. 200 Healthy Volunteers control group
You may qualify if:
- Who were younger than 60 years at recruitment
- Had been interviewed at baseline and at the two follow-up interviews
- Had provided biospecimens for research previously before the age of 65 years (2000-2004)
- Who will be 65 years or older by 2013
You may not qualify if:
- Any known history of heart disease or stroke
- Anticipated life expectancy \< 1 year
- Unable to provide written informed consent to participate in the study
- Patients with cancer
- Patients with chronic renal disease
- Any metallic implants
Contact the study team to confirm eligibility.
Sponsors & Collaborators
- National Heart Centre Singaporelead
- National University of Singaporecollaborator
Study Sites (1)
National Heart Centre Singapore
Singapore, Singapore, 169609, Singapore
Related Publications (7)
Wong JJ, Zhang H, Leng S, Gao F, Zhao X, Tan K, Tan RS, Zhong L, Koh AS. Superior aortic strain and ventriculoarterial coupling in older women are moderately correlated with Framingham 10-year risk. Eur Heart J Imaging Methods Pract. 2025 Jun 4;3(1):qyaf075. doi: 10.1093/ehjimp/qyaf075. eCollection 2025 Jan.
PMID: 40584917DERIVEDWang LYT, Lim WS, Tan RS, Teo LLY, Tan SY, Ooi CH, Ong ACW, Kovalik JP, Goh J, Gao F, Koh AS. Frequency, intensity and duration of physical activity is associated with frailty in older adults with cardiac aging. Sci Rep. 2025 May 5;15(1):15679. doi: 10.1038/s41598-025-00657-4.
PMID: 40325063DERIVEDChng ACC, Tan HC, Teo LLY, Tan RS, Ewe SH, Leng S, Zhao XD, Zhong L, Koh WP, Kovalik JP, Gao F, Koh AS. Associations between glycated haemoglobin and multi-modal imaging markers of early cardiac aging. Geroscience. 2025 Apr;47(2):1911-1921. doi: 10.1007/s11357-024-01387-7. Epub 2024 Oct 14.
PMID: 39397221DERIVEDZhang H, Leng S, Gao F, Kovalik JP, Tan RS, Wee HN, Chua KV, Ching J, Zhao X, Allen J, Wu Q, Leiner T, Zhong L, Koh AS. Longitudinal aortic strain, ventriculo-arterial coupling and fatty acid oxidation: novel insights into human cardiovascular aging. Geroscience. 2024 Dec;46(6):5459-5471. doi: 10.1007/s11357-024-01127-x. Epub 2024 Mar 22.
PMID: 38514519DERIVEDTan YH, Lim JP, Lim WS, Gao F, Teo LLY, Ewe SH, Keng BMH, Tan RS, Koh WP, Koh AS. Obesity in Older Adults and Associations with Cardiovascular Structure and Function. Obes Facts. 2022;15(3):336-343. doi: 10.1159/000521729. Epub 2022 Mar 4.
PMID: 35249039DERIVEDKovalik JP, Zhao X, Gao F, Leng S, Chow V, Chew H, Teo LLY, Tan RS, Ewe SH, Tan HC, Wee HN, Lee LS, Ching J, Keng BMH, Koh WP, Zhong L, Koh AS. Amino acid differences between diabetic older adults and non-diabetic older adults and their associations with cardiovascular function. J Mol Cell Cardiol. 2021 Sep;158:63-71. doi: 10.1016/j.yjmcc.2021.05.009. Epub 2021 May 24.
PMID: 34033835DERIVEDKoh AS, Velmurugan B, Gao F, Tan RS, Wong JI, Teo LLY, Keng BMH, Chua SJM, Yuan JM, Koh WP, Cheung C. Value of soluble Urokinase plasminogen activator receptor over age as a biomarker of impaired myocardial relaxation. BMC Geriatr. 2017 Nov 28;17(1):275. doi: 10.1186/s12877-017-0668-0.
PMID: 29179674DERIVED
Biospecimen
The blood will be stored for genetic tests and development of cell lines to study genetic risks for aging related diseases and cardiovascular disease.
MeSH Terms
Interventions
Intervention Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Su-Mei Angela Koh, MBBS
National Heart Centre Singapore
Central Study Contacts
Study Design
- Study Type
- observational
- Observational Model
- CASE CONTROL
- Time Perspective
- PROSPECTIVE
- Sponsor Type
- OTHER
- Responsible Party
- SPONSOR
Study Record Dates
First Submitted
May 31, 2016
First Posted
June 6, 2016
Study Start
July 1, 2014
Primary Completion
April 1, 2017
Study Completion
April 1, 2017
Last Updated
June 16, 2016
Record last verified: 2016-05
Data Sharing
- IPD Sharing
- Will not share