Measuring Cerebral Blood Flow Using Pseudo-continuous Arterial Spin Labeling Perfusion Magnetic Resonance Imaging

NCT02767609 | Completed Results

• 1 other identifier: 5140083
• Study Type: interventional
• Target: 1
• Locations: 0 countries
• Sites: N/A

Brief Summary

This study will test a new MRI sequence that measures cerebral blood flow (CBF). Because this technique for measuring CBF is new, there is little information on what the normal values for different regions of the brain should be. Information from the study will be used to establish normative CBF values for the brain, improving the reliable use of this technique for the diagnosis of brain injury or disease.

Conditions

Traumatic Brain Injury; Multiple Sclerosis; Alzheimer's Disease; Tumor

Outcome Measures

Primary Outcomes (1)

• Regional Cerebral Blood Flow Values of the Brain Measured Using Pseudo-continuous Arterial Spin Labeling (pCASL) MRI.

  The relative cerebral blood flow (CBF) in frontal, parietal, occipital gray matter and white matter regions, basal ganglia, thalami, and cerebellum will be measured using region of interest analysis to determine institutional normative values for healthy subjects.

  single encounter

Study Arms (1)

Magentic Resonance Imaging

EXPERIMENTAL

magnetic Resonance Imaging.

Device: Magnetic Resonance Imaging

Interventions

Magnetic Resonance Imaging DEVICE

All participants will have be given a MRI using a pseudo-continuous arterial spin labeling perfusion sequence.

Magentic Resonance Imaging

Eligibility Criteria

• Age: 18 Years - 90 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Any person between the ages of 18-90 years, who is undergoing routine magnetic resonance imaging (MRI) of the head with or without contrast at Loma Linda University Medical Center.
• Must be eligible for MRI (no electronic or metal implants that are not MR compatible).

You may not qualify if:

• Electronic or metal implant that is not MRI safe, pregnancy or claustrophobia.

Sponsors & Collaborators

• Loma Linda University: lead

MeSH Terms

Conditions

Brain Injuries, Traumatic; Multiple Sclerosis; Alzheimer Disease; Neoplasms

Interventions

Magnetic Resonance Imaging

Condition Hierarchy (Ancestors)

Brain Injuries; Brain Diseases; Central Nervous System Diseases; Nervous System Diseases; Craniocerebral Trauma; Trauma, Nervous System; Wounds and Injuries; Demyelinating Autoimmune Diseases, CNS; Autoimmune Diseases of the Nervous System; Demyelinating Diseases; Autoimmune Diseases; Immune System Diseases; Dementia; Tauopathies; Neurodegenerative Diseases; Neurocognitive Disorders; Mental Disorders

Intervention Hierarchy (Ancestors)

Tomography; Diagnostic Imaging; Diagnostic Techniques and Procedures; Diagnosis

Results Point of Contact

• Title: Brenda Bartnik Olson
• Organization: Loma Linda University medical Center

bbartnik@llu.edu

909-558-4000

Study Officials

• Brenda Bartnik Olson, PhD

  Loma Linda University Medical Center

  PRINCIPAL INVESTIGATOR

Publication Agreements

• PI is Sponsor Employee: No
• Restrictive Agreement: No

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Purpose: BASIC SCIENCE
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Associate Proffesor

Study Record Dates

• First Submitted: May 6, 2016
• First Posted: May 10, 2016
• Study Start: May 1, 2014
• Primary Completion: March 3, 2017
• Study Completion: March 3, 2017
• Last Updated: April 30, 2019
• Results First Posted: April 30, 2019

Record last verified: 2019-04

Data Sharing

• IPD Sharing: Will not share