Magnetic Resonance Imaging (MRI) Sequences Optimization in Healthy Subjects

NCT02900339 | Completed

• 2 other identifiers: 35RC11_89652011-A01531-40
• Study Type: interventional
• Target: 628
• Locations: 1 country
• Sites: 1

Brief Summary

Magnetic resonance imaging (MRI) is a noninvasive and non-ionizing (no use of X-rays) imaging modality. Today it is considered an anatomical and functional exploration reference technique. Since its inception around 1985, this technology is constantly evolving. Many advances in MRI require constant adaptations of radiological practices. The morphological image is now associated with functional and parametric information (infusion, diffusion spectroscopy, etc ...). In parallel, work combining acquisition and post-processing of data also open new applications (tractography, functional MRI, etc ....). Thus, more and more procedures are necessary to "integrate" these techniques for the diagnosis and adapt to new demands of clinicians. The type of sequence and its associated parameters allow to directly influence the contrast of images, to characterize tissue compared to another and, ultimately, to highlight morphological or functional abnormality. Image quality can be optimized on each MRI, depending on the time available for the acquisition on the one hand, and on the desired resolution and contrast, on the other hand. For each sequence, it is therefore necessary to find a compromise that will optimize the diagnostic quality of the examination. This optimization requires a phase focusing on healthy volunteers. It is therefore important that researchers and physicists could design on healthy volunteers, the best settings of all parameters for an image or spectrum. Indeed, it is always necessary to properly optimize every parameter choices before beginning a study of a cohort of patients. In this context, the main objective of this study is to optimize sequences and imaging protocols to evaluate and validate the choice of parameters in healthy volunteers.

Conditions

Healthy Volunteers

Keywords

MRI; Sequence optimization; Healthy volunteers

Outcome Measures

Primary Outcomes (1)

• Quantitative assessment of acquired sequences

  Quality images, maps or spectra acquired with optimized parameters will be compared to standard acquisitions. This evaluation will be based on quantitative criteria extracted from computer analysis of the data : signal to noise ratio, contrast-to-noise, blur level, information sharing, collocation of areas set evidenced by the different techniques, etc...

  One day after data acquisitions

Secondary Outcomes (1)

• Qualitative assessment of acquired sequences

  One day after data acquisitions

Study Arms (1)

MR parameters optimization

EXPERIMENTAL

The study will be conducted on the MRI of the Neurinfo platform, in the radiology department of the University Hospital of Rennes.

Device: Magnetic Resonance Imaging

Interventions

Magnetic Resonance Imaging DEVICE

MRI of the Neurinfo platform is an MRI 3 Tesla Magnetom Verio model, Siemens (Siemens Healthcare, Erlangen, Germany). This imager is marked for European Conformity (CE), ensuring compliance with European Union safety standards.

Also known as: Magnetom

MR parameters optimization

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Men or women aged over 18 years
• Written informed consent given

You may not qualify if:

• contraindication to MRI :
• Claustrophobia
• morphotype not allowing access to MRI
• Wear a metallic implant, such as:
• Pacemaker (pacemaker)
• Ferromagnetic surgical clips
• Intra orbital metallic foreign bodies or encephalic
• Pregnancy
• Breastfeeding
• Adults under guardianship, trusteeship or safeguard justice
• No social Insurance

Sponsors & Collaborators

• Rennes University Hospital: lead

Study Sites (1)

Radiology Department CHU de Rennes

Rennes, 35033, France

Location

MeSH Terms

Interventions

Magnetic Resonance Imaging

Intervention Hierarchy (Ancestors)

Tomography; Diagnostic Imaging; Diagnostic Techniques and Procedures; Diagnosis

Study Officials

• Jean-Christophe FERRE, MD, PhD

  CHU Rennes

  STUDY DIRECTOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Purpose: DIAGNOSTIC
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: September 9, 2016
• First Posted: September 14, 2016
• Study Start: April 18, 2013
• Primary Completion: October 12, 2021
• Study Completion: October 12, 2021
• Last Updated: December 14, 2022

Record last verified: 2022-12

Data Sharing

• IPD Sharing: Will not share

Locations

FR (1)