Verticality Perception - Effects of Prolonged Roll-tilt in Healthy Human Subjects

NCT02760173 | Withdrawn

• 1 other identifier: vert_perc_posttilt
• Study Type: interventional
• Target: N/A
• Locations: 0 countries
• Sites: N/A

Brief Summary

The long-term goal of this research is to advance our knowledge of how the brain combines the information of multiple sensory systems coding for spatial orientation and how adaptation to vestibular imbalance influences spatial orientation. In healthy human subjects verticality perception is accurate while upright. After prolonged roll-tilt, humans show a systematic bias in perceived direction towards the previous roll-tilted position (so-called "post-tilt bias"). Here we evaluate different potential explanations for this bias using both vision-dependent and vision-independent paradigms of verticality perception.

Conditions

Vestibular; Perception

Keywords

verticality perception

Outcome Measures

Primary Outcomes (1)

• Adjustment errors and trial-to-trial variability as assessed by line adjustments (subjective visual vertical (SVV)), adjustments of a rod (subjective haptic vertical (SHV)) or self-adjustments (subjective postural vertical (SPV)) after prolonged roll

  In all three paradigms (SVV, SHV and SPV) the percept of direction of gravity will be assessed. Parameters will be adjustment errors ("accuracy") and trial-to-trial variability ("precision") based on repetitive adjustments of a luminous line (SVV) or a rod (SHV) after returning to upright position after a period of 5min in static roll-tilt at 90° left-ear down or right-ear down. During the roll-tilt period subjects remain either in the dark or observe a rotating optokinetic (random dot) pattern. Individual mean values and standard deviation (SD) will be calculated for all conditions. Adjustments with the joystick (SPV) will start from 90° ear-down positions after 5min of static roll.

  measurements will be obtained over periods of 5min in a single session and day

Secondary Outcomes (1)

• Impact of a rotating optokinetic stimulus (velocity 60°/s) on adjustment errors as assessed by the SVV, the SHV or the SPV after 5min of static roll-tilt at +/- 90° roll.

  measurements will be obtained over periods of 5min in a single session and day

Study Arms (1)

Single intervention arm

EXPERIMENTAL

This is the only arm in this study, measuring verticality perception after prolonged roll-tilt over 5min.

Other: perception of vertical after static roll-tilt over 5min

Interventions

perception of vertical after static roll-tilt over 5min OTHER

subjects will indicate perceived direction of vertical after 5min of static whole-body roll-tilt.

Single intervention arm

Eligibility Criteria

• Age: 18 Years - 65 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• ages 18-65 years
• informed consent

You may not qualify if:

• peripheral-vestibular deficit
• disturbed consciousness
• history of sensory deficits
• visual field deficits
• other neurological or systemic disorder which can cause dementia or cognitive dysfunction
• intake of antidepressants, sedatives, or neuroleptics
• pregnancy, unless excluded by a negative pregnancy test
• known neck pain or status post neck trauma

Sponsors & Collaborators

• University of Zurich: lead

Study Officials

• Dominik Straumann, MD

  University of Zurich, Switzerland

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Purpose: BASIC SCIENCE
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: April 26, 2016
• First Posted: May 3, 2016
• Study Start: June 1, 2016
• Primary Completion: July 1, 2016
• Study Completion: June 28, 2018
• Last Updated: July 2, 2018

Record last verified: 2018-06

Data Sharing

• IPD Sharing: Will not share