Propagation Waves in Tactile Material Perception

NCT05253508 | Unknown

• 1 other identifier: NL75084.058.21
• Study Type: interventional
• Target: 15
• Locations: 1 country
• Sites: 1

Brief Summary

During the exploration of surfaces with the bare finger, vibratory signals arise and propagate through the finger and hand. While research into mechanical and neural response characteristics has demonstrated that these signals carry rich information about touched objects and their properties, only little is known about the role these propagation waves play in human perception and to which extent the somatosensory system is able to collect information from afferents at more proximal locations than the skin-object surface. Using ring-block anaesthesia (lidocaine) we will temporarily inhibit haptic feedback sensations of healthy participants' index finger during interactions with 3D-printed surface probes that are systematically varied in two important material dimensions, namely their roughness and hardness (elasticity), while the participants carry out a well-established psychophysical discrimination task. The results will then be compared to a control condition without anaesthesia. An accelerometer sensor, placed on the dorsal side of the hand, will serve to simultaneously record the propagating tactile waves. Given their role in material perception, thermal cues will be monitored during the experiment with a thermometer and the hydration level of the fingertip skin will be measured regularly using a corneometer. This research will allow us to understand the role of propagation waves in material perception. It seeks to uncover some of the perceptual mechanisms that remain intact during surface discrimination of textured, compliant surfaces, while local information is temporarily inhibited. The results will have implications for how we provide feedback about material properties for sensorimotor control to this living with prosthetic limbs. It is hypothesised that propagation waves that arise during these haptic interactions contain behaviourally relevant information used for the discrimination of surface properties.

Conditions

Sensory Processing; Perception; Sense of Touch; Taction

Outcome Measures

Primary Outcomes (1)

• Change in discrimination thresholds

  The (statistical) difference between psychophysical measures (i.e., difference limen/discrimination thresholds) when the index finger is anaesthetised as compared to non-anaesthetized.

  one year

Study Arms (1)

Healthy human participants

EXPERIMENTAL

ring-block anaesthesia with lidocaine in one of the two visits

Drug: Lidocaine 2% Injectable Solution

Interventions

Lidocaine 2% Injectable Solution DRUG

A digital nerve block by injections to the base of the finger

Healthy human participants

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• years or older;
• No reported psychiatric or neurological disorders;
• Able to provide informed consent;
• Voluntary participation with written informed consent.

You may not qualify if:

• Is pregnant or currently breastfeeding;
• Has a known Lidocaine allergy;
• Is currently undergoing any other medical intervention or taking part in a study involving one;
• Has a history of finger/hand/upper limb trauma or disease;
• Has a disease affecting normal motor functioning.

Sponsors & Collaborators

• Reinier Haga Orthopedisch Centrum: lead
• Delft University of Technology: collaborator

Study Sites (1)

Reinier Haga Orthopedic Center

Zoetermeer, 2725 NA, Netherlands

RECRUITING

MeSH Terms

Interventions

Lidocaine

Intervention Hierarchy (Ancestors)

Acetanilides; Anilides; Amides; Organic Chemicals; Aniline Compounds; Amines

Central Study Contacts

Karina Driller

CONTACT

+45 30484333; k.k.driller@tudelft.nl

Nina Mathijssen

CONTACT

+31647208490; N.Mathijssen@rhoc.nl

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Purpose: BASIC SCIENCE
• Intervention Model: SEQUENTIAL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Model Details: Repeated-measures design, order randomized

Study Record Dates

• First Submitted: February 2, 2022
• First Posted: February 23, 2022
• Study Start: January 1, 2022
• Primary Completion: March 15, 2022
• Study Completion: March 30, 2022
• Last Updated: February 23, 2022

Record last verified: 2022-02

Locations

NL (1)