Tap to "Tap", Pathobiome Associates Health Care

NCT02751658 | Completed

• 1 other identifier: 9648
• Study Type: interventional
• Target: 410
• Locations: 0 countries
• Sites: N/A

Brief Summary

The bacteria live in community and in some cases it is the combination of several microorganisms that facilitates transmission and pathogenicity. The concept of pathobiome follows from this finding. Investigators hypothesize that the microbial community water point is a pathobiome influencing installation and transmission of pathogens associated with care

Conditions

Otorhinolaryngologic Diseases

Outcome Measures

Primary Outcomes (1)

• Presence of Pseudomonas aeruginosa

  The presence of Pseudomonas aeruginosa will be made from a buccal swab in all patients admitted to the hospital entrance. Mark of Pseudomonas aeruginosa will be done with and without trypticase soy broth enrichment and isolation on selective agar cetrimide Pseudomonas aeruginosa . The enrichment will detect a port at very low inoculum knowing that the purpose of the analysis is to detect passing of Pseudomonas aeruginosa from the environment to the patient regardless of the associated infectivity. The identification of certainty will be carried out by MALDI-TOF. If several morphotypes are visualized on agar Cetrimide they will all be identified and kept under custody broth at -20 ° C.

  Entrance hospitalization (Day 1)

Secondary Outcomes (1)

• Presence of infection with Pseudomonas aeruginosa

  Exit hospitalization (Day 10)

Study Arms (1)

patients in the Otorhinolaryngology

OTHER

patients in the Otorhinolaryngology department realization of a levy into the mouth swab on the day of admission to hospital and the day of release

Other: mouth swab

Interventions

mouth swab OTHER

Levy to make inside of the mouth with a swab on the day of admission to hospital and the day of release at the patients in the Otorhinolaryngology

patients in the Otorhinolaryngology

Eligibility Criteria

• Age: 18 Years - 90 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Patients in the Otorhinolaryngology department

You may not qualify if:

• Immunocompromised patients
• Patient Opposition to enter the research protocol

Sponsors & Collaborators

• University Hospital, Montpellier: lead

Related Publications (2)

• Benigno V, Carraro N, Sarton-Loheac G, Romano-Bertrand S, Blanc DS, van der Meer JR. Diversity and evolution of an abundant ICEclc family of integrative and conjugative elements in Pseudomonas aeruginosa. mSphere. 2023 Dec 20;8(6):e0051723. doi: 10.1128/msphere.00517-23. Epub 2023 Oct 30.

  PMID: 37902330 DERIVED

• Virieux-Petit M, Hammer-Dedet F, Aujoulat F, Jumas-Bilak E, Romano-Bertrand S. From Copper Tolerance to Resistance in Pseudomonas aeruginosa towards Patho-Adaptation and Hospital Success. Genes (Basel). 2022 Feb 4;13(2):301. doi: 10.3390/genes13020301.

  PMID: 35205346 DERIVED

MeSH Terms

Conditions

Otorhinolaryngologic Diseases

Study Officials

• Sara ROMANO-BERTRAND, MCU-PH

  University Hospital, Montpellier

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Purpose: DIAGNOSTIC
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: March 4, 2016
• First Posted: April 26, 2016
• Study Start: November 8, 2016
• Primary Completion: December 18, 2017
• Study Completion: July 29, 2019
• Last Updated: July 31, 2019

Record last verified: 2019-07