Metabolic and Appetite Responses to a Whey Protein Preload Following Prior Exercise in Overweight Males

NCT02714309 | Completed

• 1 other identifier: HLSDA190116
• Study Type: interventional
• Target: 12
• Locations: 1 country
• Sites: 1

Brief Summary

Consuming whey protein may have beneficial effects on health, principally by having an impact on blood glucose metabolism, but also by affecting appetite. The purpose of this project is to investigate the effect of consuming whey protein preload prior to breakfast, following a bout of low/moderate intensity exercise (brisk walking), on glucose and lipids in the blood as well as on appetite. It is hypothesised that the consumption of whey protein before a meal after prior low/moderate intensity exercise may positively affect postprandial handling as well as appetite sensations and consequently reduce intake at a subsequent meal.

Conditions

Obesity, Abdominal

Keywords

Postprandial glycemia; Metabolic health measures

Outcome Measures

Primary Outcomes (1)

• Postprandial blood glucose responses

  Blood glucose concentration determined in whole blood sampled at regular intervals post-breakfast

  0-240 minutes post breakfast

Secondary Outcomes (1)

• Energy intake at ad libitum lunch meal

  240 minutes post breakfast breakfast

Study Arms (3)

Control Trial

EXPERIMENTAL

A mixed macronutrient breakfast meal is consumed without additional protein, following a period of rest. An ad libitum lunch meal is subsequently consumed.

Other: Mixed macronutrient breakfast meal; Other: Ad libitum lunch meal

Exercise No Preload Trial

EXPERIMENTAL

Following an exercise bout a mixed macronutrient breakfast meal is consumed without additional protein. An ad libitum lunch meal is subsequently consumed.

Other: Mixed macronutrient breakfast meal; Other: Ad libitum lunch meal; Other: Low/moderate intensity exercise

Exercise With Preload Trial

EXPERIMENTAL

Following low/moderate intensity exercise bout, whey protein (20g) administered prior to consumption of mixed macronutrient breakfast meal. An ad libitum lunch meal is subsequently consumed.

Dietary Supplement: Whey protein; Other: Mixed macronutrient breakfast meal; Other: Ad libitum lunch meal; Other: Low/moderate intensity exercise

Interventions

Whey protein DIETARY_SUPPLEMENT

20 g whey protein isolate (Arla Foods Ingredients Group) added to 200ml water and served as a beverage

Exercise With Preload Trial

Mixed macronutrient breakfast meal OTHER

A standardised mixed-macronutrient breakfast served to all participants. The macronutrient distribution of the breakfast is 13% protein, 70% carbohydrate, 17% fat (1958 kilojoules (kJ); 468 kcal total)

Control Trial; Exercise No Preload Trial; Exercise With Preload Trial

Ad libitum lunch meal OTHER

A mixed-macronutrient lunch served to all participants ad libitum. The macronutrient distribution of the lunch is 14% protein, 51% carbohydrate, 35% fat

Control Trial; Exercise No Preload Trial; Exercise With Preload Trial

Low/moderate intensity exercise OTHER

A 30 minute bout of treadmill walking is performed on a motorised treadmill at a low/moderate intensity (55% estimated VO2max)

Exercise No Preload Trial; Exercise With Preload Trial

Eligibility Criteria

• Age: 18 Years - 55 Years
• Sex: male
• Healthy Volunteers: No
• Age Groups: Adult (18-64)

Criteria for inclusion are as follows: * Male * Aged 18-55 years * Abdominal obesity (Waist circumference \> 102 cm) * Sedentary (not currently participating in structured physical activity) Criteria for exclusion are as follows: * Cardiovascular, metabolic or renal disease * Current illness * Regular breakfast skipper * Food allergies or intolerances * Eating disorders * Smoker * Inadequate venous access * Taking medication that may affect metabolism

Contact the study team to discuss eligibility requirements. They can help determine if this study is right for you.

Sponsors & Collaborators

• Northumbria University: lead

Study Sites (1)

Faculty of Health and Life Sciences, Northumbria University

Newcastle upon Tyne, Tyne and Wear, NE1 8ST, United Kingdom

Location

Related Publications (1)

• Allerton DM, West DJ, Stevenson EJ. Whey protein consumption following fasted exercise reduces early postprandial glycaemia in centrally obese males: a randomised controlled trial. Eur J Nutr. 2021 Mar;60(2):999-1011. doi: 10.1007/s00394-020-02304-2. Epub 2020 Jun 22.

  PMID: 32572617 DERIVED

MeSH Terms

Conditions

Obesity, Abdominal

Interventions

Whey Proteins

Condition Hierarchy (Ancestors)

Obesity; Overweight; Overnutrition; Nutrition Disorders; Nutritional and Metabolic Diseases; Body Weight; Signs and Symptoms; Pathological Conditions, Signs and Symptoms

Intervention Hierarchy (Ancestors)

Milk Proteins; Animal Proteins, Dietary; Dietary Proteins; Proteins; Amino Acids, Peptides, and Proteins; Whey; Milk; Dairy Products; Food; Diet, Food, and Nutrition; Physiological Phenomena; Food and Beverages

Study Officials

• Penny L Rumbold, PhD

  Northumbria University

  STUDY DIRECTOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: PARTICIPANT
• Purpose: BASIC SCIENCE
• Intervention Model: CROSSOVER
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: March 16, 2016
• First Posted: March 21, 2016
• Study Start: March 1, 2016
• Primary Completion: July 1, 2016
• Study Completion: July 1, 2016
• Last Updated: July 6, 2016

Record last verified: 2016-07

Data Sharing

• IPD Sharing: Will not share

Locations

GB (1)