Metabolic and Appetite Responses to Altered Timing of Whey Protein Ingestion

NCT02658110 | Completed

• 1 other identifier: HLSDA020415
• Study Type: interventional
• Target: 14
• Locations: 1 country
• Sites: 1

Brief Summary

The proposed study aims to determine the metabolic and appetite responses to standard breakfast and lunch meals whilst altering the timing of whey protein supplementation. Currently, the designs implemented in many studies mean that it is unclear whether an optimum time for whey protein consumption exists in order to promote the greatest acute health benefits. A number of studies have investigated the effects of whey protein when consumed as a preload to a subsequent meal, whilst benefits have also been shown when whey protein is ingested with a meal. The proposed study will therefore investigate strategies of whey protein supplementation that vary in their practical applicability, using meals that reflect regular eating behaviours throughout the population in a sample of overweight/obese individuals. Findings from this study may provide important information regarding the efficacy of whey protein supplementation before, during and after a composite meal, and its effect on the handling of a subsequent mixed-macronutrient meal.

Conditions

Obesity, Abdominal

Keywords

Postprandial glycemia; Metabolic health measures

Outcome Measures

Primary Outcomes (1)

• Postprandial blood glucose responses

  Blood glucose concentration determined in whole blood sampled at regular intervals post-breakfast and post-lunch

  0-360 minutes post breakfast

Secondary Outcomes (1)

• Acute subjective appetite responses

  0-360 minutes post breakfast

Study Arms (4)

Non Protein Trial

SHAM COMPARATOR

Mixed Macronutrient Breakfast Meal and Mixed Macronutrient Lunch Meal served without additional whey protein

Other: Mixed Macronutrient Breakfast Meal; Other: Mixed Macronutrient Lunch Meal

Preload Trial

EXPERIMENTAL

Whey protein (20g) administered 15 minutes prior to Mixed Macronutrient Breakfast Meal

Dietary Supplement: Whey Protein; Other: Mixed Macronutrient Breakfast Meal; Other: Mixed Macronutrient Lunch Meal

With Meal Trial

EXPERIMENTAL

Whey protein (20g) administered alongside Mixed Macronutrient Breakfast Meal

Dietary Supplement: Whey Protein; Other: Mixed Macronutrient Breakfast Meal; Other: Mixed Macronutrient Lunch Meal

Post Meal Trial

EXPERIMENTAL

Whey protein (20g) administered 15 minutes after Mixed Macronutrient Breakfast Meal

Dietary Supplement: Whey Protein; Other: Mixed Macronutrient Breakfast Meal; Other: Mixed Macronutrient Lunch Meal

Interventions

Whey Protein DIETARY_SUPPLEMENT

20 g whey protein isolate (Arla Foods Ingredients Group) added to 200ml water and served as a beverage

Post Meal Trial; Preload Trial; With Meal Trial

Mixed Macronutrient Breakfast Meal OTHER

A standardised mixed-macronutrient breakfast served to all participants. The macronutrient distribution of the breakfast is 13% protein, 70% carbohydrate, 17% fat (1958 kJ; 468 kcal total)

Non Protein Trial; Post Meal Trial; Preload Trial; With Meal Trial

Mixed Macronutrient Lunch Meal OTHER

A standardised mixed-macronutrient lunch served to all participants. The macronutrient distribution of the lunch is 14% protein, 51% carbohydrate, 35% fat (3506 kJ; 838 kcal total)

Non Protein Trial; Post Meal Trial; Preload Trial; With Meal Trial

Eligibility Criteria

• Age: 18 Years - 55 Years
• Sex: male
• Healthy Volunteers: No
• Age Groups: Adult (18-64)

Criteria for inclusion are as follows: * Male * Aged 18-55 years * Abdominal obesity (Waist circumference \> 102 cm) * Sedentary (not currently participating in structured physical activity) Criteria for exclusion are as follows: * Metabolic disease or current illness * Regular breakfast skipper * Food allergies/intolerances * Eating disorders * Smoking

Contact the study team to discuss eligibility requirements. They can help determine if this study is right for you.

Sponsors & Collaborators

• Northumbria University: lead

Study Sites (1)

Faculty of Health and Life Sciences, Northumbria University

Newcastle upon Tyne, Tyne and Wear, NE1 8ST, United Kingdom

Location

MeSH Terms

Conditions

Obesity, Abdominal

Interventions

Whey Proteins

Condition Hierarchy (Ancestors)

Obesity; Overweight; Overnutrition; Nutrition Disorders; Nutritional and Metabolic Diseases; Body Weight; Signs and Symptoms; Pathological Conditions, Signs and Symptoms

Intervention Hierarchy (Ancestors)

Milk Proteins; Animal Proteins, Dietary; Dietary Proteins; Proteins; Amino Acids, Peptides, and Proteins; Whey; Milk; Dairy Products; Food; Diet, Food, and Nutrition; Physiological Phenomena; Food and Beverages

Study Officials

• Emma J Stevenson, PhD

  Northumbria University

  STUDY DIRECTOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: PARTICIPANT
• Purpose: BASIC SCIENCE
• Intervention Model: CROSSOVER
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: January 14, 2016
• First Posted: January 18, 2016
• Study Start: July 1, 2015
• Primary Completion: October 1, 2015
• Study Completion: October 1, 2015
• Last Updated: January 18, 2016

Record last verified: 2016-01

Data Sharing

• IPD Sharing: Will not share

Locations

GB (1)