A Genome-wide Association Study on the Endophenotype of Spatial Working Memory in ADHD

NCT02710929 | Completed DMC

• 1 other identifier: 201412157RINA
• Study Type: observational
• Target: 232
• Locations: 1 country
• Sites: 1

Brief Summary

Specific Aims:

1. 1.To find the genetic variations associated with spatial working memory performance in patients with ADHD by using genome-wide association studies (GWAS);
2. 2.To find the genetic variations associated with spatial working memory performance in healthy subjects by using GWAS;
3. 3.To recruit a validation sample and to replicate the findings from the initial GWAS;
4. 4.To test whether genetic variations significantly associated with spatial working memory are also associated with ADHD.

Conditions

Attention-deficit/Hyperactivity Disorder

Outcome Measures

Primary Outcomes (1)

• Psychiatric interview

  Subjects will be interviewed by Chinese Version of the Kiddie Epidemiologic version of the Schedule for Affective Disorders and Schizophrenia (K-SADS-E)

  1 hour

Secondary Outcomes (1)

• Spatial working memory

  30 minutes

Study Arms (2)

ADHD group

Subjects with clinical diagnosis of ADHD according to the DSM-IV criteria

TD group

Typically development controls without lifetime diagnosis with ADHD

Eligibility Criteria

• Age: 7 Years - 18 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Child (0-17), Adult (18-64)
• Sampling Method: Non-Probability Sample

Study Population

The existing sample is composed of 382 children withADHD and 150 healthy subjects. We plan to recruit additional 232 healthy subjects (104 in the first year; 128 in the second year), aged 7 to 18 years.

You may qualify if:

• Subjects without any current or lifetime DSM-IV psychiatric disorders based on the K-SADS-E interviews.

You may not qualify if:

• Participants who had any past or current medical or neurological illness, who currently took psychotropic medication, or whose intelligence quotient (IQ) score was less than 80 were excluded.

Sponsors & Collaborators

• National Taiwan University Hospital: lead

Study Sites (1)

National Taiwan Univeristy Hospital

Taipei, Taiwan

Location

Biospecimen

Retention: SAMPLES WITH DNA

15 ml blood will be withdrawn from the subjects (one heparin-rinsed tube for cell culture, one EDTA rinsed tube for DNA extraction)

MeSH Terms

Conditions

Attention Deficit Disorder with Hyperactivity

Condition Hierarchy (Ancestors)

Attention Deficit and Disruptive Behavior Disorders; Neurodevelopmental Disorders; Mental Disorders

Study Officials

• Chi-Yung Shang, MD

  Dept of Psychiatry, National Taiwan University Hospital

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: March 13, 2016
• First Posted: March 17, 2016
• Study Start: August 1, 2015
• Primary Completion: July 31, 2018
• Study Completion: July 31, 2018
• Last Updated: September 2, 2021

Record last verified: 2021-09

Data Sharing

• IPD Sharing: Will not share

Locations

TW (1)