Validity of ADHD Subtypes Using Neuropsychological Measure

NCT00494819 | Completed DMC

• 2 other identifiers: 9461700916NSC 94-2815-C-002-177-H
• Study Type: observational
• Target: 122
• Locations: 1 country
• Sites: 1

Brief Summary

Background: Attention-Deficit/Hyperactivity Disorder (ADHD), characterized by inattention, hyperactivity, and impulsivity, is among the most common neuropsychiatric disorders worldwide (5-10% at school age) and in Taiwan (7.5%). The DSM-IV ADHD consists of three subtypes: predominantly Inattentive (ADHD-I), predominantly Hyperactivity/Impulsivity (ADHD-H), and Combined subtypes (ADHD-C). Although the DSM-IV field trials indicate that the current subtypes differ significantly on variables such as age of onset, gender ratio, and level of social and academic impairment, little has been addressed whether the DSM-IV subtypes differ neuropsychologically. Numerous researches have proved that stimulants (methylphenidate is the only stimulant in Taiwan) are the most effective medication in treating ADHD. Although the efficacy of methylphenidate on behavioral measures has been established in Taiwan, there is no information about neuropsychological measures. Specific Aims:

1. 1.to validate ADHD subtype by neuropsychological measures; and
2. 2.to investigate the efficacy of methylphenidate on the improvement of executive functioning among children with ADHD.

Conditions

Attention-deficit/Hyperactivity Disorder

Keywords

ADHD, subtype, methylphenidate, neuropsychological measures

Eligibility Criteria

• Age: 7 Years - 10 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17)
• Sampling Method: Non-Probability Sample

Study Population

children with ADHD

You may qualify if:

• patients who have clinically diagnosis of DSM-IV ADHD confirmed by the K-SADS-E, are aged 7-10, and have IQ \> 80; and who and whose parents consent to this study

You may not qualify if:

• if they have a history of brain injury or epilepsy, visual/auditory deficit or were diagnosed as having motor disorder, obsessive-compulsive disorder, mental retardation, mood disorders, pervasive developmental disorder, or schizophrenia

Sponsors & Collaborators

• National Taiwan University Hospital: lead

Study Sites (1)

National Taiwan Univeristy Hospital

Taipei, 10002, Taiwan

Location

Related Publications (1)

• Chiang M, Gau SS. Validation of attention-deficit-hyperactivity disorder subtypes among Taiwanese children using neuropsychological functioning. Aust N Z J Psychiatry. 2008 Jun;42(6):526-35. doi: 10.1080/00048670802050603.

  PMID: 18465380 DERIVED

MeSH Terms

Conditions

Attention Deficit Disorder with Hyperactivity

Condition Hierarchy (Ancestors)

Attention Deficit and Disruptive Behavior Disorders; Neurodevelopmental Disorders; Mental Disorders

Study Officials

• Susan Shur-Fen Gau, MD, PhD

  National Taiwan University Hospital & College of Medicine

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: June 29, 2007
• First Posted: July 2, 2007
• Study Start: September 1, 2005
• Study Completion: August 1, 2006
• Last Updated: November 14, 2012

Record last verified: 2008-08

Locations

TW (1)