Addressing Motion and Confounds Issues in Resting fMRI- Application of Multi-echo EPI Scanning

NCT02720562 | Completed DMC

• 1 other identifier: 201406032RINB
• Study Type: observational
• Target: 80
• Locations: 0 countries
• Sites: N/A

Brief Summary

Resting state functional MRI is widely used for studying brain functional networks. However, in-scanner head movement and other non-neuronal noise can disproportionately bias connectivity estimates, despite various preprocessing efforts. To address these issues, the technique combining data acquisition with multiecho (ME) echo planar imaging and analysis with spatial independent component analysis (ICA), called ME-ICA, has been develop to distinguish BOLD (neuronal) and non-BOLD (artifactual) components based on linear echo-time dependence of signals, and has been demonstrated to successfully remove non-neuronal confounds. Nonetheless, such research approach has never been applied in psychiatric populations. The study aims to fill in the gap as shown in the following.

Conditions

Attention-deficit/Hyperactivity Disorder

Outcome Measures

Primary Outcomes (1)

• Psychiatric Interview

  Subjects will be interviewed by Chinese Version of the Kiddie Epidemiologic version of the Schedule for Affective Disorders and Schizophrenia (K-SADS-E)

  1 hour

Study Arms (2)

ADHD group

Subjects with clinical diagnosis of ADHD according to the DSM-IV criteria

TD group

Typically development controls without lifetime diagnosis with ADHD

Eligibility Criteria

• Age: 18 Years - 35 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64)
• Sampling Method: Non-Probability Sample

Study Population

The sample consists of 40 adults with ADHD and 40 age-, sex-matched healthy volunteers.

You may qualify if:

• \. Subjects who have clinical diagnosis of a ADHD according to the DSM-IV and DSM-5 diagnostic criteria

You may not qualify if:

• Systemic medical illness
• Current symptoms or lifetime history of DSM-5 diagnosis of mood disorder, any psychotic disorder, substance use disorder, learning disability, pervasive developmental disorder, claustrophobia, obsessive compulsive disorder, or mental retardation.
• With neurodegenerative disorder, epilepsy, involuntary movement disorder, congenital metabolic disorder, brain tumor, history of severe head trauma, and history of craniotomy;
• Full-scale IQ \< 80.

Sponsors & Collaborators

• National Taiwan University Hospital: lead

MeSH Terms

Conditions

Attention Deficit Disorder with Hyperactivity

Condition Hierarchy (Ancestors)

Attention Deficit and Disruptive Behavior Disorders; Neurodevelopmental Disorders; Mental Disorders

Study Officials

• Hsiang-Yuan Lin, MD

  Dept of Psychiatry, National Taiwan University Hospital

  PRINCIPAL INVESTIGATOR

• Susan Shur-Fen Gau, MD, PhD

  National Taiwan University Hospital & College of Medicine

  STUDY DIRECTOR

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: March 22, 2016
• First Posted: March 28, 2016
• Study Start: January 1, 2015
• Primary Completion: December 1, 2015
• Last Updated: March 28, 2016

Record last verified: 2016-03