Use of EBUS TBNA for Cell Culture as an Aid to Diagnose Lung Cancer and Lymphoma

NCT02710565 | Completed

• 1 other identifier: B723
• Study Type: interventional
• Target: 22
• Locations: 1 country
• Sites: 2

Brief Summary

Participants who are scheduled to have an endo bronchial ultrasound (EBUS) trans bronchial needle aspiration (TBNA) will provide additional samples. These samples will then be sent to Imperial College London to see whether a cell line can be grown. If growth is successful then the samples will be returned to our pathology department to see if grading is possible and then to compare these results with the previous diagnostic samples. The cell line samples will not be used for patient diagnosis.

Conditions

Lung Cancer; Lymphoma; Non-small Cell Lung Cancer; Non-Hodgkin Lymphoma; Mediastinal Lymphadenopathy

Keywords

Endo bronchial ultrasound; Trans bronchial needle aspiration; Cell line; Lung cancer

Outcome Measures

Primary Outcomes (1)

• Cell culture growth

  Are samples from EBUS TBNA suitable for cell culture?

  upto 50 Weeks

Secondary Outcomes (1)

• Diagnostic benefit

  upto 50 Weeks

Study Arms (1)

Cohort

OTHER

Participants who are scheduled to have an endo bronchial ultrasound (EBUS) trans bronchial needle aspiration (TBNA) will provide additional samples. These samples will then be sent to Imperial College London to see whether a cell line can be grown. If growth is successful then the samples will be returned to our pathology department to see if grading is possible and then to compare these results with the previous diagnostic samples. The cell line samples will not be used for patient diagnosis.

Other: Cohort

Interventions

Cohort OTHER

Obtaining additional EBUS TBNA samples for cell culture

Also known as: EBUS TBNA

Cohort

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Male or females aged \>18 years
• Completed Chest CT
• Written informed consent

You may not qualify if:

• Patients with active tuberculosis (TB)
• Pregnancy
• Patients with significant psychiatric and or neurological comorbidity

Sponsors & Collaborators

• Mid and South Essex NHS Foundation Trust: lead
• Imperial College London: collaborator

Study Sites (2)

Basildon Hospital

Basildon, Essex, SS16 5NL, United Kingdom

Location

Imperial College London

London, W12 0NN, United Kingdom

Location

MeSH Terms

Conditions

Lung Neoplasms; Lymphoma; Carcinoma, Non-Small-Cell Lung; Lymphoma, Non-Hodgkin

Interventions

Cohort Studies

Condition Hierarchy (Ancestors)

Respiratory Tract Neoplasms; Thoracic Neoplasms; Neoplasms by Site; Neoplasms; Lung Diseases; Respiratory Tract Diseases; Neoplasms by Histologic Type; Lymphoproliferative Disorders; Lymphatic Diseases; Hemic and Lymphatic Diseases; Immunoproliferative Disorders; Immune System Diseases; Carcinoma, Bronchogenic; Bronchial Neoplasms

Intervention Hierarchy (Ancestors)

Epidemiologic Studies; Epidemiologic Study Characteristics; Epidemiologic Methods; Investigative Techniques; Health Care Evaluation Mechanisms; Quality of Health Care; Health Care Quality, Access, and Evaluation; Public Health; Environment and Public Health

Study Officials

• Dipak Mukherjee, MRCP MBBS

  Mid and South Essex NHS Foundation Trust

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Purpose: BASIC SCIENCE
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: March 7, 2016
• First Posted: March 17, 2016
• Study Start: February 1, 2016
• Primary Completion: July 1, 2017
• Study Completion: July 1, 2017
• Last Updated: December 23, 2020

Record last verified: 2020-12

Data Sharing

• IPD Sharing: Will not share

Locations

GB (2)