CD36 and Human Fat Taste Perception

NCT02699567 | Completed

• 1 other identifier: 201011853
• Study Type: observational
• Target: 97
• Locations: 1 country
• Sites: 1

Brief Summary

The purpose of this study is to determine the effect of common human variants in in taste related genes, such as CD36 gene, a putative fat taste receptor, affect fat taste perception.

Conditions

Obesity

Keywords

taste perception; individual differences; fat; genetics

Outcome Measures

Primary Outcomes (2)

• Scores in the general labeled magnitude scale for fat flavor intensity

  One to 12 weeks following screening

• Scores in the hedonic general labeled magnitude scale for fat flavor hedonic value

  One to 12 weeks following screening

Secondary Outcomes (1)

• Number of participants who are PROP taster as assessed by sip and spit testing procedure of water with increasing PROP concentrations.

  One to 12 weeks following screening

Study Arms (4)

Lean AA

Subjects with a BMI\<=25 kg/m2 and carriers of a CD36 gene variation associated with low CD36 expression levels

Other: No intervention

Obese AA

Subjects with a BMI\>29.9 kg/m2 and carriers of a CD36 gene variation associated with low CD36 expression levels

Other: No intervention

Lean GG

Subjects with a BMI\<=25 kg/m2 and carriers of a CD36 gene variation associated with high CD36 expression levels

Other: No intervention

Obese GG

Subjects with a BMI\>29.9 kg/m2 and carriers of a CD36 gene variation associated with high CD36 expression levels

Other: No intervention

Interventions

No intervention OTHER

Lean AA; Lean GG; Obese AA; Obese GG

Eligibility Criteria

• Age: 21 Years - 50 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)
• Sampling Method: Non-Probability Sample

Study Population

Subjects will be men and women, 21 to 50 yrs of age of all races and ethnic groups. The two groups (i.e. groups with different CD36 genetic variants) will be matched as closely as possible in age, sex, body mass index and race distributions. Subject population will consist of lean subjects (BMI \>18-\<25 kg/m2) and subjects with obesity (BMI \>29.9 kg/m2).

You may qualify if:

• BMI \>18-\<25 kg/m2 or BMI\>29.9 kg/m2.
• to 50 years of age

You may not qualify if:

• Previous malabsorptive or restrictive gastrointestinal surgery
• Smoking
• Pregnancy or breastfeeding
• Diabetes
• Taking medication that might affect taste perception

Sponsors & Collaborators

• Washington University School of Medicine: lead
• Monell Chemical Senses Center: collaborator

Study Sites (1)

Washington University School of Medicine

St Louis, Missouri, 63110, United States

Location

Biospecimen

Retention: SAMPLES WITH DNA

Extracted genomic DNA

MeSH Terms

Conditions

Obesity; Platelet Glycoprotein IV Deficiency

Condition Hierarchy (Ancestors)

Overweight; Overnutrition; Nutrition Disorders; Nutritional and Metabolic Diseases; Body Weight; Signs and Symptoms; Pathological Conditions, Signs and Symptoms

Study Officials

• Marta Y Pepino de Gruev, PhD

  Washington University School of Medicine

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Assistant Professor of Medicine

Study Record Dates

• First Submitted: February 25, 2016
• First Posted: March 4, 2016
• Study Start: November 1, 2011
• Primary Completion: April 1, 2013
• Study Completion: July 1, 2014
• Last Updated: March 4, 2016

Record last verified: 2016-02

Data Sharing

• IPD Sharing: Will not share

Locations

US (1)