Prediction Value of Ecg on Coronary Slow-flow

NCT02650557 | Completed

• 1 other identifier: PECS-sysu
• Study Type: observational
• Target: 998
• Locations: 1 country
• Sites: 1

Brief Summary

The investigators aimed to investigate the vessel heterogeneity of Thrombolysis in Myocardial Infarction frame count (TFC) in the three coronary arteries, and its relation to P-wave dispersion, in patients with coronary slow flow and otherwise normal coronary arteries.

Conditions

Coronary Slow Flow

Keywords

coronary slow flow; P-wave dispersion

Outcome Measures

Primary Outcomes (1)

• Average thrombolysis in myocardial infarction (TIMI) frame count (TFC) in the three coronary arteries and its relation to P waves parameters on ECG in patients with CSF and otherwise normal coronary arteries

  The first frame was defined as the frame in which concentrated dye occupies the full width of the proximal coronary artery lumen, touching both borders of the lumen, and indicates forward motion down the artery. The final frame counted is that in which the contrast first reaches the distal predefined landmark branch without the necessity for full opacification. The difference between maximum and minimum P wave duration (Pmax and Pmin) was calculated from the 12-lead ECG and defined as PWD.

  24-72 hours

Secondary Outcomes (1)

• maximum and minimum P wave duration (Pmax and Pmin) and major adverse cardiac events (MACE) in patients with CSF and otherwise normal coronary arteries

  24 hours-30 days

Study Arms (2)

CSF group

consecutive patients with angiographically documented CSF

Procedure: angiography

control group

age- and gender-matched control subjects

Procedure: angiography

Interventions

angiography PROCEDURE

angiography or arteriography is a medical imaging technique used to visualize the inside, or lumen, of blood vessels and organs of the body, with particular interest in the arteries, veins, and the heart chambers. This is traditionally done by injecting a radio-opaque contrast agent into the blood vessel and imaging using X-ray based techniques such as fluoroscopy.

CSF group; control group

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

All of the subjects had chest pain and were referred to our catheterization laboratory for coronary angiography. Diagnosis of CSF was based on thrombolysis in myocardial infarction (TIMI) frame count (TFC).

You may qualify if:

• All of the subjects had chest pain and were referred to our catheterization laboratory for coronary angiography

You may not qualify if:

• Valvular or congenital heart disease
• Atrial fibrillation or other arrhythmia that would interfere with ECG analysis
• Left ventricular hypertrophy
• Myocardial or pericardial disease
• Chronic obstructive pulmonary disease, or electrolyte abnormalities.
• Subjects taking antiarrhythmic, antiischemic, β-blocker, or calcium-channel blocker medications were also excluded from the study.

Sponsors & Collaborators

• Sun Yat-sen University: lead

Study Sites (1)

Xiaodong Zhaung

Guangzhou, Guangdong, 510080, China

Location

MeSH Terms

Interventions

Cerebral Angiography

Intervention Hierarchy (Ancestors)

Neuroradiography; Neuroimaging; Diagnostic Imaging; Diagnostic Techniques and Procedures; Diagnosis; Angiography; Radiography; Diagnostic Techniques, Cardiovascular; Diagnostic Techniques, Neurological; Investigative Techniques

Study Officials

• zhimin du, MD

  fitst affiliated hospital of SYSU

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: department of cardiology, first affiliated hoapital of SYSU

Study Record Dates

• First Submitted: January 3, 2016
• First Posted: January 8, 2016
• Study Start: January 1, 2014
• Primary Completion: October 1, 2015
• Study Completion: October 1, 2015
• Last Updated: January 8, 2016

Record last verified: 2016-01

Data Sharing

• IPD Sharing: Will not share

Locations

CN (1)