High-Sensitive CRP and Carotid Stiffness Between Patients With and Without Coronary Slow Flow

NCT07076745 | Completed

• 1 other identifier: Soh-Med-25-5-6PD
• Study Type: observational
• Target: 60
• Locations: 1 country
• Sites: 1

Brief Summary

This study aims to compare the levels of high-sensitivity C-reactive protein (hs-CRP) and carotid artery stiffness between patients with coronary slow flow phenomenon (CSFP) and those with normal coronary flow.

Conditions

High-sensitivity C-reactive Protein; Carotid Stiffness; Coronary Slow Flow

Outcome Measures

Primary Outcomes (1)

• High Sensitive C-reactive protein

  High Sensitive C-reactive protein will be measured.

  24 hours post-angiography

Secondary Outcomes (1)

• Stiffness indices

  24 hours post-angiography

Study Arms (2)

Study group

Patients diagnosed with coronary slow flow based on corrected thrombolysis in myocardial infarction (TIMI) frame count (cTFC) \>27.

Diagnostic Test: High-sensitivity C-reactive protein; Other: Stiffness Measurement

Control group

Patients with normal coronary angiographic flow and no obstructive coronary artery disease.

Diagnostic Test: High-sensitivity C-reactive protein; Other: Stiffness Measurement

Interventions

High-sensitivity C-reactive protein DIAGNOSTIC_TEST

High-sensitivity C-reactive protein will be done.

Control group; Study group

Stiffness Measurement OTHER

Measurements will include carotid intima-media thickness (CIMT), systolic (Ds) and diastolic (Dd) diameters, and calculation of stiffness indices: * β-stiffness index. * Peterson's elastic modulus (Ep). * Distensibility coefficient (DC). * Compliance coefficient (CC). * Strain.

Control group; Study group

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

This case-control study will be conducted at Sohag University Hospitals after approval from the institutional ethical committee

You may qualify if:

• Age ≥18 years old.
• Both sexes.
• Patients undergo coronary angiography for evaluation of chest pain or suspected ischemia.

You may not qualify if:

• Pregnant or breastfeeding women.
• History of cardiovascular events such as myocardial infarction or stroke.
• Diagnosed autoimmune disorders, chronic hepatic or renal diseases.
• Current or recent infections.
• History of malignancy.
• Patients taking medications known to affect inflammatory markers (e.g., corticosteroids or immunosuppressants).

Sponsors & Collaborators

• Sohag University: lead

Study Sites (1)

Sohag University

Sohag, 82511, Egypt

Location

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Lecturer of Cardiovascular, Faculty of Medicine, Sohag University, Sohag, Egypt.

Study Record Dates

• First Submitted: July 12, 2025
• First Posted: July 22, 2025
• Study Start: January 1, 2025
• Primary Completion: July 10, 2025
• Study Completion: July 10, 2025
• Last Updated: July 22, 2025

Record last verified: 2025-07

Data Sharing

• IPD Sharing: Will share
• Shared Documents: STUDY PROTOCOL
• Time Frame: After the end of study for one year.
• Access Criteria: The data will be available upon a reasonable request from the corresponding author.

Locations

EG (1)