Glycemic Responses and of the Autonomic Cardiac Function in Diabetes Type-2 Women Post Resistance Exercise

NCT02645448 | Completed DMC

• 1 other identifier: UFSaoFrancisco
• Study Type: interventional
• Target: 12
• Locations: 0 countries
• Sites: N/A

Brief Summary

The aim of this study was to investigate and correlate the glucose responses and VFC 24 hours after resistance exercise (RE) sessions at different intensities in women with type 2 diabetes (DM-2). Twelve women with DM-2 were invited to perform by one week in randomized order, two weeks interventions with experimental sessions: Session Control (CONT) without conducting RE, RE session (40% or 80% of one maximum repetition - 1RM) on day 2 and day 3 was observed the effect of the length of RE session by 11h. After that, initiated the experimental sessions, where after each of the analysis of glucose 24h by continuous monitoring system of glucose was performed, considering breakfast, lunch, dinner and sleep, and analysis performed of the RR series by a period of 48h. During control sessions, the subjects were seated comfortably for 40min and RE sessions, 40%1RM and 80%1RM, were performed in medium circuit 3 sets with 16 and 8 replications and recovery range between 60 exercises and 90seg , respectively, and between the circuits 120sec. It was observed that the concentration of glucose in the period of 24h after the session has been reduced to 40% 1RM vs. CONT and 80%1RM. Hyperglycemia was prevalent in the period 34h of the sessions CONT and 80%1RM, respectively , being different from the session 40%1RM. In postprandial times, shorter hyperglycemia was found in the session to 40% 1RM vs. CONT and 80% 1RM after breakfast, lunch and dinner. At the time of sleep, less time in hyperglycemia was found between sessions of 40% 1RM vs. 80% 1RM. Significant correlations (p \<0.01) were found between glucose 24h with cardiac autonomic RRi variables, HF, LF and reason LF:HF.

Conditions

Diabetes Mellitus; Autonomic Diseases

Keywords

Resistance Exercise; Diabetes Mellitus; Heart Rate Variability

Outcome Measures

Primary Outcomes (1)

• Concentration of glucose and hyperglycemia prevalence

  Acute bout of resistance exercise at 40% 1RM (low intensity) reduced glucose concentrations and the prevalence of hyperglycemia in 73.1 ± 37.7% and 68.4 ± 51.1% compared to the sessions CONT40% and resistance exercise 80% 1RM (high intensity) respectively in 24h from each session.

  24 hours

Secondary Outcomes (2)

• Heart Rate Variability

  24 hours

• Correlation between heart rate variability and glucose 24 hours

  24 hours

Study Arms (2)

Resistance Exercise Low intensity

OTHER

Day 1 (Control Session) Day 2 (Resistance Exercise) Day 3 (Duration of effect)

Other: Resistance Exercise

Resistance Exercise High intensity

OTHER

Day 1 (Control Session) Day 2 (Resistance Exercise) Day 3 (Duration of effect)

Other: Resistance Exercise

Interventions

Resistance Exercise OTHER

Control Session Resistance exercise at different intensities (40%1RM or 80%1RM) Duration of effect

Resistance Exercise High intensity; Resistance Exercise Low intensity

Eligibility Criteria

• Age: 40 Years - 60 Years
• Sex: female
• Healthy Volunteers: No
• Age Groups: Adult (18-64)

You may qualify if:

• Being female, diagnosed with type 2 diabetes (DM-2) and be clinically stable, and be aged between 40 and 60 years.

You may not qualify if:

• Make use of exogenous insulin
• Have morbid obesity (BMI\> 40 kg / m2)
• Provide uncompensated glucose and abnormalities in the electrocardiogram (ECG) at rest with suggestion of cardiac ischemia from above or below unevenness in the ST segment\> 2mm or reversal in T wave
• Presenting heart disease
• Proliferative diabetic retinopathy
• Severe autonomic neuropathy
• Any limb amputation
• Uncontrolled hypertension (systolic\> 160 mmHg and / or diastolic BP\> 100 mmHg)
• Diabetic nephropathy (albuminuria ≥ 14mg / L or\> 30mg / 24h) chronic renal failure (SBD, 2014; ADA, 2014)
• Osteo-myo-articular problems that limited the exercises and being a smoker.

Sponsors & Collaborators

• Universidade Federal do vale do São Francisco: lead
• Coordenação de Aperfeiçoamento de Pessoal de Nível Superior.: collaborator

MeSH Terms

Conditions

Diabetes Mellitus; Autonomic Nervous System Diseases

Interventions

Resistance Training

Condition Hierarchy (Ancestors)

Glucose Metabolism Disorders; Metabolic Diseases; Nutritional and Metabolic Diseases; Endocrine System Diseases; Nervous System Diseases

Intervention Hierarchy (Ancestors)

Exercise Therapy; Rehabilitation; Aftercare; Continuity of Patient Care; Patient Care; Therapeutics; Physical Therapy Modalities; Physical Conditioning, Human; Exercise; Motor Activity; Movement; Musculoskeletal Physiological Phenomena; Musculoskeletal and Neural Physiological Phenomena

Study Officials

• Loumaíra Carvalho da Cruz

  Universidade Federal do vale do São Francisco

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: PARTICIPANT
• Intervention Model: CROSSOVER
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principal Investigator

Study Record Dates

• First Submitted: December 12, 2015
• First Posted: January 1, 2016
• Study Start: November 1, 2014
• Primary Completion: August 1, 2015
• Study Completion: September 1, 2015
• Last Updated: January 1, 2016

Record last verified: 2015-12

Data Sharing

• IPD Sharing: Will not share