NCT02152839

Brief Summary

Maintenance of body's skeletal muscle is key to a healthy older age. However, as we age we lose on average 1-2% of our muscle each year. In order to slow this loss we need to understand fully the mechanisms regulating muscle mass with ageing. In this project we aim to determine these mechanisms using a new novel technique of 'heavy' water ingestion, which will allow us to measure multiple aspects of skeletal muscle mass control during normal everyday activities in young and old individuals over a period of 6 weeks. We will also determine the influence of resistance exercise training during this period in offsetting declines in muscle with ageing using this method

Trial Health

80
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
20

participants targeted

Target at P25-P50 for not_applicable healthy

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

May 1, 2013

Completed
1.1 years until next milestone

First Submitted

Initial submission to the registry

May 29, 2014

Completed
4 days until next milestone

First Posted

Study publicly available on registry

June 2, 2014

Completed
29 days until next milestone

Primary Completion

Last participant's last visit for primary outcome

July 1, 2014

Completed
Last Updated

July 31, 2015

Status Verified

July 1, 2015

Enrollment Period

1.2 years

First QC Date

May 29, 2014

Last Update Submit

July 30, 2015

Conditions

Healthy

Outcome Measures

Primary Outcomes (1)

  • Muscle Protein Synthesis

    Comparison of muscle protein synthesis between young and older individuals and in response to 6 weeks unilateral exercise training

    0-6 Weeks

Secondary Outcomes (1)

  • Muscle Sub fractions

    0-6 week

Other Outcomes (1)

  • Muscle Functions

    0-6 Weeks

Study Arms (2)

Old Unilateral Exercise

EXPERIMENTAL

Old individuals (65-75y) studied before and after 6 weeks of unilateral resistance exercise training

Behavioral: Resistance Exercise

Young Unilateral Exercise

EXPERIMENTAL

Young Individuals (18-30y) studied before and after 6 weeks unilateral resistance exercise training

Behavioral: Resistance Exercise

Interventions

Resistance ExerciseBEHAVIORAL

6 Weeks progressive unilateral resistance exercise, 3 times per week, 70% 1-RM, 6 x 8 Repetitions. 2 minutes rest between sets

Old Unilateral ExerciseYoung Unilateral Exercise

Eligibility Criteria

Age18 Years - 75 Years
Sexmale
Healthy VolunteersYes
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • Young (18-30y) and old men (65-75y) who are generally healthy and recreationally active

You may not qualify if:

  • Active cardiovascular disease
  • Cerebrovascular disease including previous stroke, aneurysm (large vessel or intracranial)
  • Respiratory disease including pulmonary hypertension or COPD
  • Hyper/ hypo parathyroidism, hyper/ hypothyroidism, Cushing's disease, diabetes
  • Active inflammatory bowel disease
  • Renal disease
  • Malignancy
  • Recent steroid treatment (within 6 mo), or hormone replacement therapy
  • Clotting dysfunction
  • Musculoskeletal or neurological disorders
  • Any disease requiring long-term drug prescriptions, including statins

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Royal Derby Hospital Medical School

Derby, DE22 3DT, United Kingdom

Location

Related Publications (1)

  • Brook MS, Wilkinson DJ, Tarum J, Mitchell KW, Lund JL, Phillips BE, Szewczyk NJ, Kadi F, Greenhaff PL, Smith K, Atherton PJ. Neither myonuclear accretion nor a myonuclear domain size ceiling is a feature of the attenuated hypertrophic potential of aged human skeletal muscle. Geroscience. 2023 Feb;45(1):451-462. doi: 10.1007/s11357-022-00651-y. Epub 2022 Sep 9.

    PMID: 36083436DERIVED

MeSH Terms

Interventions

Resistance Training

Intervention Hierarchy (Ancestors)

Exercise TherapyRehabilitationAftercareContinuity of Patient CarePatient CareTherapeuticsPhysical Therapy ModalitiesPhysical Conditioning, HumanExerciseMotor ActivityMovementMusculoskeletal Physiological PhenomenaMusculoskeletal and Neural Physiological Phenomena

Study Officials

  • Philip Atherton, PhD, AFHEA

    University of Nottingham

    PRINCIPAL INVESTIGATOR

Study Design

Study Type
interventional
Phase
not applicable
Allocation
NON RANDOMIZED
Masking
NONE
Purpose
PREVENTION
Intervention Model
PARALLEL
Sponsor Type
OTHER
Responsible Party
SPONSOR

Study Record Dates

First Submitted

May 29, 2014

First Posted

June 2, 2014

Study Start

May 1, 2013

Primary Completion

July 1, 2014

Last Updated

July 31, 2015

Record last verified: 2015-07

Locations

GB(1)