Speech and Short-term Memory Functions in Dyslexia: a Combined MEG and EEG Study

NCT02622360 | Unknown

• 1 other identifier: 12345
• Study Type: observational
• Target: 50
• Locations: 1 country
• Sites: 1

Brief Summary

Developmental dyslexia is a highly heritable disorder in which reading skills are compromised despite normal intelligence and appropriate reading instruction. Reading problems in dyslexia are thought to primarily originate from weak speech sound representations or poor phonological skills. Dyslexia has also been associated with short-term or working memory dysfunctions. The current study will address the presence of these problems in dyslexic adults by the means of recording auditory and audio-visual mismatch negativity (MMN) and its magnetic counterpart (MMNm) to determine neural speech sound discrimination, representations and integration of seen and heard language. In addition to analyzing neural processing of syllables or (pseudo-)words, a new approach to MEG acquisition and analysis to characterize the neural responses during comprehension of complex real-life speech will be used. Furthermore, reading, phonological and cognitive skills of these participants will be determined with a neuropsychological test battery. The associations between the neural, neuropsychological and genetic measures will be studied. This project will illuminate the nature of neurocognitive dysfunctions in dyslexia and their relationship with genes.

Conditions

Dyslexia

Outcome Measures

Primary Outcomes (1)

• Magnetic mismatch negativity brain responses to speech sound changes

  2 hours

Secondary Outcomes (4)

• Magnetoencephalographic amplitude envelope inter-subject correlation during listening to complex real-life speech

  2 hours

• Event-related brain responses to pseudowords

  first 25% and last 25% of the measurement time (total 2 hours)

• Correlation of event-related brain responses to susceptibility genes for dyslexia

  1 year

• Source localization of audio-visual integration processes

  2 hours

Study Arms (2)

Dyslexia

Individuals with confirmed dyslexia.

Control

Healthy control subjects.

Eligibility Criteria

• Age: 18 Years - 45 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)
• Sampling Method: Probability Sample

Study Population

50 Finnish healthy adult subjects aged 18-45 will be tested, around half of who have a developmental dyslexia. Prior to the study, subjects are given "Written investigation information" after which the subjects may participate in the study by signing the "Written informed consent". Participants in the dyslexia group are required to have a prior diagnosis of dyslexia as an inclusion criterion. Groups will be matched for gender, age and educational level. The participation to the experiment is on voluntary basis after announcement through different channels, e.g. via email lists. All experiments will be carried out according to the Declaration of Helsinki.

You may qualify if:

• year old
• Finnish-speaking
• right-handed
• normal hearing and normal or corrected-to-normal vision
• dyslexic (if not, it is possible to participate as a control participant)

You may not qualify if:

• known neurological or psychiatric diseases
• history of alcohol or drug abuse
• metal in the body

Sponsors & Collaborators

• University of Helsinki: lead
• Helsinki University Central Hospital: collaborator
• Karolinska Institutet: collaborator

Study Sites (1)

Laboratory of CBRU, Institute of Behavioural Sciences, University of Helsinki

Helsinki, Uusimaa, 00014, Finland

Location

Related Publications (31)

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• Kujala T, Karma K, Ceponiene R, Belitz S, Turkkila P, Tervaniemi M, Naatanen R. Plastic neural changes and reading improvement caused by audiovisual training in reading-impaired children. Proc Natl Acad Sci U S A. 2001 Aug 28;98(18):10509-14. doi: 10.1073/pnas.181589198. Epub 2001 Aug 21.

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• Kujala T, Lovio R, Lepisto T, Laasonen M, Naatanen R. Evaluation of multi-attribute auditory discrimination in dyslexia with the mismatch negativity. Clin Neurophysiol. 2006 Apr;117(4):885-93. doi: 10.1016/j.clinph.2006.01.002. Epub 2006 Feb 23.

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• Kujala T, Naatanen R. The mismatch negativity in evaluating central auditory dysfunction in dyslexia. Neurosci Biobehav Rev. 2001 Aug;25(6):535-43. doi: 10.1016/s0149-7634(01)00032-x.

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• Kujala T, Tervaniemi M, Schroger E. The mismatch negativity in cognitive and clinical neuroscience: theoretical and methodological considerations. Biol Psychol. 2007 Jan;74(1):1-19. doi: 10.1016/j.biopsycho.2006.06.001. Epub 2006 Jul 17.

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• Lankinen K, Saari J, Hari R, Koskinen M. Intersubject consistency of cortical MEG signals during movie viewing. Neuroimage. 2014 May 15;92:217-24. doi: 10.1016/j.neuroimage.2014.02.004. Epub 2014 Feb 12.

  PMID: 24531052 BACKGROUND

• Leppanen PH, Richardson U, Pihko E, Eklund KM, Guttorm TK, Aro M, Lyytinen H. Brain responses to changes in speech sound durations differ between infants with and without familial risk for dyslexia. Dev Neuropsychol. 2002;22(1):407-22. doi: 10.1207/S15326942dn2201_4.

  PMID: 12405511 BACKGROUND

• Lovio R, Halttunen A, Lyytinen H, Naatanen R, Kujala T. Reading skill and neural processing accuracy improvement after a 3-hour intervention in preschoolers with difficulties in reading-related skills. Brain Res. 2012 Apr 11;1448:42-55. doi: 10.1016/j.brainres.2012.01.071. Epub 2012 Feb 7.

  PMID: 22364735 BACKGROUND

• Lovio R, Naatanen R, Kujala T. Abnormal pattern of cortical speech feature discrimination in 6-year-old children at risk for dyslexia. Brain Res. 2010 Jun 4;1335:53-62. doi: 10.1016/j.brainres.2010.03.097. Epub 2010 Apr 8.

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• Mittag M, Thesleff P, Laasonen M, Kujala T. The neurophysiological basis of the integration of written and heard syllables in dyslexic adults. Clin Neurophysiol. 2013 Feb;124(2):315-26. doi: 10.1016/j.clinph.2012.08.003. Epub 2012 Aug 30.

  PMID: 22939780 BACKGROUND

• Naatanen R, Lehtokoski A, Lennes M, Cheour M, Huotilainen M, Iivonen A, Vainio M, Alku P, Ilmoniemi RJ, Luuk A, Allik J, Sinkkonen J, Alho K. Language-specific phoneme representations revealed by electric and magnetic brain responses. Nature. 1997 Jan 30;385(6615):432-4. doi: 10.1038/385432a0.

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• Naatanen R, Paavilainen P, Rinne T, Alho K. The mismatch negativity (MMN) in basic research of central auditory processing: a review. Clin Neurophysiol. 2007 Dec;118(12):2544-90. doi: 10.1016/j.clinph.2007.04.026. Epub 2007 Oct 10.

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• Naatanen R, Pakarinen S, Rinne T, Takegata R. The mismatch negativity (MMN): towards the optimal paradigm. Clin Neurophysiol. 2004 Jan;115(1):140-4. doi: 10.1016/j.clinph.2003.04.001.

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• Neuhoff N, Bruder J, Bartling J, Warnke A, Remschmidt H, Muller-Myhsok B, Schulte-Korne G. Evidence for the late MMN as a neurophysiological endophenotype for dyslexia. PLoS One. 2012;7(5):e34909. doi: 10.1371/journal.pone.0034909. Epub 2012 May 14.

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• Ramus F. Dyslexia. Talk of two theories. Nature. 2001 Jul 26;412(6845):393-5. doi: 10.1038/35086683. No abstract available.

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• Salmelin R. Clinical neurophysiology of language: the MEG approach. Clin Neurophysiol. 2007 Feb;118(2):237-54. doi: 10.1016/j.clinph.2006.07.316. Epub 2006 Sep 27.

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• Scerri TS, Schulte-Korne G. Genetics of developmental dyslexia. Eur Child Adolesc Psychiatry. 2010 Mar;19(3):179-97. doi: 10.1007/s00787-009-0081-0. Epub 2009 Nov 29.

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• Schulte-Korne G, Deimel W, Bartling J, Remschmidt H. Auditory processing and dyslexia: evidence for a specific speech processing deficit. Neuroreport. 1998 Jan 26;9(2):337-40. doi: 10.1097/00001756-199801260-00029.

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• Schumacher J, Anthoni H, Dahdouh F, Konig IR, Hillmer AM, Kluck N, Manthey M, Plume E, Warnke A, Remschmidt H, Hulsmann J, Cichon S, Lindgren CM, Propping P, Zucchelli M, Ziegler A, Peyrard-Janvid M, Schulte-Korne G, Nothen MM, Kere J. Strong genetic evidence of DCDC2 as a susceptibility gene for dyslexia. Am J Hum Genet. 2006 Jan;78(1):52-62. doi: 10.1086/498992. Epub 2005 Nov 17.

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• Shtyrov Y, Nikulin VV, Pulvermuller F. Rapid cortical plasticity underlying novel word learning. J Neurosci. 2010 Dec 15;30(50):16864-7. doi: 10.1523/JNEUROSCI.1376-10.2010.

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• Temple E. Brain mechanisms in normal and dyslexic readers. Curr Opin Neurobiol. 2002 Apr;12(2):178-83. doi: 10.1016/s0959-4388(02)00303-3.

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• Wolf M. Rapid alternating stimulus naming in the developmental dyslexias. Brain Lang. 1986 Mar;27(2):360-79. doi: 10.1016/0093-934x(86)90025-8.

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• Lyon, G.R. et al., 2003. Defining Dyslexia , Comorbidity , Teachers ' Knowledge of Language and Reading A Definition of Dyslexia. Annals of Dyslexia, 53(1), pp.1-14.

  BACKGROUND

• Nevala, J., Kairaluoma, L. & Ahonen, T., 2006. Lukemis-ja kirjoittamistaitojen yksilötestistö nuorille ja aikuisille. Jyväskylä: Niilo Mäki

  BACKGROUND

• Wechsler, D., 1997. Wechsler Adult Intelligence Scale (Third Edition), San Antonio, TX: The Psychological Corporation. Helsinki: Psykologien kustannus Oy.

  BACKGROUND

• Wechsler, D., 1997. The Wechsler Memory Scale (Third Edition), San Antonio, TX: The Psychological Corporation. Helsinki: Psykologien kustannus Oy.

  BACKGROUND

Related Links

• Suppanen, E., 2014. Inter-subject correlation of MEG data during movie viewing. Master's thesis, Aalto University School of Electrical Engineering.
• Thiede, A., 2014. Magnetoencephalographic (MEG) Inter-subject Correlation using Continuous Music Stimuli. Master's thesis, Aalto University School of Science.

Biospecimen

Retention: SAMPLES WITH DNA

extraction of DNA from whole blood samples or saliva

MeSH Terms

Conditions

Dyslexia

Condition Hierarchy (Ancestors)

Language Disorders; Communication Disorders; Neurobehavioral Manifestations; Neurologic Manifestations; Nervous System Diseases; Specific Learning Disorder; Learning Disabilities; Signs and Symptoms; Pathological Conditions, Signs and Symptoms; Neurodevelopmental Disorders; Mental Disorders

Study Officials

• Teija Kujala, Prof.

  Cognitive Brain Research Unit, Institute of Behavioural Sciences, University of Helsinki

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Prof.

Study Record Dates

• First Submitted: November 11, 2015
• First Posted: December 4, 2015
• Study Start: July 1, 2015
• Primary Completion: April 1, 2017
• Study Completion: April 1, 2021
• Last Updated: October 30, 2019

Record last verified: 2019-10

Locations

FI (1)