NCT02615756

Brief Summary

In this study, we use positron emission tomography (PET) and functional magnetic resonance imaging (fMRI) to study brain mechanisms that contribute to physical exercise-induced reward. We examine whether acute physical exercise releases endogenous opioids in the brain, and whether it modulates brain responses to viewing appetizing foods. Unraveling these mechanism are instrumental from a public health perspective, given the undisputed positive health effects of physical exercise.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
24

participants targeted

Target at below P25 for not_applicable

Timeline
Completed

Started Apr 2013

Longer than P75 for not_applicable

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

April 1, 2013

Completed
1.4 years until next milestone

First Submitted

Initial submission to the registry

September 10, 2014

Completed
1.2 years until next milestone

First Posted

Study publicly available on registry

November 26, 2015

Completed
2.5 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

June 1, 2018

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

June 1, 2018

Completed
Last Updated

March 9, 2021

Status Verified

March 1, 2021

Enrollment Period

5.2 years

First QC Date

September 10, 2014

Last Update Submit

March 4, 2021

Conditions

Physical Exercise Behavior (Liking/Aversion)

Outcome Measures

Primary Outcomes (1)

  • Binding of [11C]carfentanil in brain confirmed by positron emission tomography

    Change in binding of \[11C\]carfentanil in baseline and 20 min after physical exercise completion

    Baseline and 20 min after physical exercise completion

Study Arms (1)

Physical exercise

EXPERIMENTAL
Behavioral: Exercise

Interventions

ExerciseBEHAVIORAL
Physical exercise

Eligibility Criteria

Age18 Years - 65 Years
Sexmale
Healthy VolunteersYes
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • Native Finnish speaker
  • Age \> 18 years
  • Western Caucasian origin

You may not qualify if:

  • Age \< 18 or \> 65
  • History or current mental disorder
  • BMI \> 27 kg/m2
  • Use of drugs that influence the central nervous system, including nicotine
  • Poor compliance
  • Any chronic medical defect or injury which hinder or interfere everyday life
  • Eating disorder
  • Current or past excessive use of alcohol or substance abuse
  • Past dose of radiation from medical research such that the annual effective dose will exceed 10 mSv
  • Any other condition that in the opinion of the investigator could create a hazard to the subject safety, endanger the study procedures or interfere with the interpretation of study results
  • Presence of any ferromagnetic objects that would make MR imaging contraindicated

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Turku PET Centre

Turku, 20810, Finland

Location

MeSH Terms

Interventions

Exercise

Intervention Hierarchy (Ancestors)

Motor ActivityMovementMusculoskeletal Physiological PhenomenaMusculoskeletal and Neural Physiological Phenomena

Study Design

Study Type
interventional
Phase
not applicable
Allocation
NA
Masking
NONE
Purpose
BASIC SCIENCE
Intervention Model
SINGLE GROUP
Sponsor Type
OTHER GOV
Responsible Party
SPONSOR

Study Record Dates

First Submitted

September 10, 2014

First Posted

November 26, 2015

Study Start

April 1, 2013

Primary Completion

June 1, 2018

Study Completion

June 1, 2018

Last Updated

March 9, 2021

Record last verified: 2021-03

Data Sharing

IPD Sharing
Will not share

Locations

FI(1)