Exercise and Tumor Blood Flow in Breast Cancer Patients

NCT04416087 | Unknown

• 1 other identifier: T148/2020
• Study Type: interventional
• Target: 20
• Locations: 1 country
• Sites: 1

Brief Summary

This research aims at investigating tumor blood flow response to acute exercise in human cancer patients. It is hypothesized and expected that acute exercise increases tumor blood flow, which could plausibly increase the efficacy of cancer treatment.

Conditions

Cancer, Breast

Outcome Measures

Primary Outcomes (1)

• Tumor blood flow

  Measured with PET and radiowater (\[(15)O\]H2O) tracer. Tumor perfusion will be determined as mean tumor blood flow.

  Tumor blood flow is measured at one time point, at least two (2) days apart from baseline fitness test assessment. Tumor blood flow at rest and during supine cycling exercise will be measured on the same day.

Secondary Outcomes (1)

• Spatial dispersion (heterogeneity) of tumor blood flow

  The heterogeneity of tumor blood flow is measured at one time point, at least two (2) days apart from baseline fitness test assessment. The heterogeneity of tumor blood flow at rest and during supine cycling exercise will be measured on the same day.

Study Arms (1)

Experimental group

EXPERIMENTAL

The experiment consists of a supine bicycle exercise in a positron emission tomography (PET) scanner. Each subject will perform the experiment as well as serve as their own control (tumor blood flow at rest vs. blood flow during exercise).

Other: Exercise

Interventions

Exercise OTHER

Positron emission tomography (PET) imaging at rest and during supine bicycle exercise Tumor blood flow and its heterogeneity will be measured with PET at rest and during supine bicycle exercise.

Experimental group

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• newly diagnosed breast cancer

You may not qualify if:

• abnormal fatigue, anemia, or physical dysfunction due to the disease

Sponsors & Collaborators

• Turku University Hospital: lead

Study Sites (1)

Turku PET Centre

Turku, 20521, Finland

RECRUITING

MeSH Terms

Conditions

Breast Neoplasms

Interventions

Exercise

Condition Hierarchy (Ancestors)

Neoplasms by Site; Neoplasms; Breast Diseases; Skin Diseases; Skin and Connective Tissue Diseases

Intervention Hierarchy (Ancestors)

Motor Activity; Movement; Musculoskeletal Physiological Phenomena; Musculoskeletal and Neural Physiological Phenomena

Study Officials

• Ilkka Heinonen, PhD

  staff

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Ilkka Heinonen, PhD

CONTACT

+35823138145; ilkka.heinonen@utu.fi

Heikki Minn, PhD

CONTACT

+35823130149; heikki.minn@tyks.fi

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Purpose: TREATMENT
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER GOV
• Responsible Party: SPONSOR

Model Details: Each subject will serve as their own control (tumor blood flow at rest vs. blood flow during exercise).

Study Record Dates

• First Submitted: June 1, 2020
• First Posted: June 4, 2020
• Study Start: September 7, 2020
• Primary Completion: December 31, 2024
• Study Completion: December 31, 2024
• Last Updated: October 6, 2020

Record last verified: 2020-10

Data Sharing

• IPD Sharing: Will not share

Locations

FI (1)