The Effects of Exercise on Depression Symptoms Using Levels of Neurotransmitters and EEG as Markers

NCT02023281 | Completed

• 1 other identifier: LU4261 from WyndhurstCC
• Study Type: interventional
• Target: 11
• Locations: 1 country
• Sites: 2

Brief Summary

The purpose of this study is to examine the effects of exercise on the symptoms of depression using serum levels of serotonin, catecholamine's, Alpha EEG asymmetry, and self-report of symptoms as markers. In an attempt to further understand the mechanisms of improved mood through exercise; this study will examine the known factors that contribute to depressed mood in a single study using serotonin and catecholamine levels via blood serum and EEG slow wave asymmetry. Such information can be useful in understanding the overall neurological components of depression and the effects of exercise on the brain in depressed individuals that would make the prescription of exercise a viable treatment option.

Conditions

Depression

Keywords

Depression; Exercise; Neurotransmitters; Catecholimines; EEG

Outcome Measures

Primary Outcomes (1)

• Scores on the Beck Depression Inventory-II

  The BDI-II is a 21 item self-report screening tool that measures symptoms of depression.

  Pre and post intervention over the 3 month span of the study

Secondary Outcomes (1)

• Serum levels of serotonin and catecholomine

  Pre and post intervention over the 3 month span of the study

Other Outcomes (1)

• Mean EEG alpha frequency data in the pre-frontal cortex.

  Pre and post intervention over the 3 month span of the study.

Study Arms (2)

Control Group

NO INTERVENTION

Control group will serve as a wait list and not be exposed to the intervention.

Experimental Group

EXPERIMENTAL

The experimental group will engage in a mild-moderate level of structured and clinically supervised exercise program for approx. 30-45 mins 2-3 days per week for 12 weeks

Behavioral: Exercise

Interventions

Exercise BEHAVIORAL

The experimental group will engage in mild-moderate level of exercise. This program will be structured and clinically supervised. Exercise will take place 2-3 days per week for a duration of 30-45 mins. for 12 weeks.

Experimental Group

Eligibility Criteria

• Age: 18 Years - 65 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• primary diagnosis of depression
• years of age
• Physically fit to engage in physical exercise

You may not qualify if:

• Participants with a history or current symptoms of psychosis
• anticipation of psychiatric medication changes over the course of the study
• Bipolar disorder or other disorder reflecting reality testing impairment.

Sponsors & Collaborators

• Liberty University: lead
• CommonSpirit Health: collaborator

Study Sites (2)

Liberty University

Lynchburg, Virginia, 24502, United States

Location

Centra Health; Health Works

Lynchburg, Virginia, 24503, United States

Location

MeSH Terms

Conditions

Depression; Motor Activity

Interventions

Exercise

Condition Hierarchy (Ancestors)

Behavioral Symptoms; Behavior

Intervention Hierarchy (Ancestors)

Motor Activity; Movement; Musculoskeletal Physiological Phenomena; Musculoskeletal and Neural Physiological Phenomena

Study Officials

• Timothy H Barclay, Ph.D.

  Liberty University

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: TREATMENT
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Assistant Professor; Licensed Clinical Psychologist

Study Record Dates

• First Submitted: December 23, 2013
• First Posted: December 30, 2013
• Study Start: March 1, 2013
• Primary Completion: May 1, 2013
• Study Completion: May 1, 2013
• Last Updated: December 30, 2013

Record last verified: 2013-12

Locations

US (2)