Brown Adipose Tissue Activation: Effect of Exercise Training and Irisin

NCT03359824 | Completed

• 1 other identifier: EXEBAT
• Study Type: interventional
• Target: 11
• Locations: 0 countries
• Sites: N/A

Brief Summary

This study investigates the brown adipose tissue (BAT) activation and metabolism using positron emission tomography (PET) imaging before and after exercise training intervention at fasting state under normal room temperature and during cold stimulation.The investigators hypothesize that BAT glucose uptake is increased after exercise and BAT becomes metabolically more active. Understanding the mechanisms of BAT activation and the role of exercise in humans is crucial to combat epidemic of obesity and diabetes.

Conditions

Physical Activity

Keywords

exercise, brown adipose tissue

Outcome Measures

Primary Outcomes (1)

• Cold-induced glucose uptake in BAT after exercise

  Glucose uptake of brown adipose tissue acquired with PET under cold exposure after exercise intervention. PET imaging is used to quantify glucose uptake in tissues

  Within one study day

Study Arms (1)

Exercise

OTHER

Arm: Exercise: Combination of moderate intensity continuous training, high intensity interval training and endurance training 5 times per week for a total of 6 weeks. Out of 5 sessions three were supervised by trainer and two sessions were performed by subjects on their own.The duration of the exercise was increased progressively. The first two weeks was 30 minutes that increased to 45 minutes in the third and fourth week. It was 60 minutes for the last two weeks.

Other: Exercise

Interventions

Exercise OTHER

Exercise

Eligibility Criteria

• Age: 18 Years - 45 Years
• Sex: male
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• Healthy sedentary volunteer
• BMI 20-25 kg/m2
• Age: 18-45 years
• No chronic diseases

You may not qualify if:

• BMI \< 20 kg/m2 or BMI \> 25 kg/m2
• Mental disorder or poor compliance
• Eating disorder or excessive use of alcohol or tobacco smoking
• Any chronic disease
• Past dose of radiation
• Presence of any ferromagnetic objects that would make MR imaging contraindicated
• Physically disability which rule out the physical fitness tests or participation in the exercise training intervention
• Any other condition that in the opinion of the investigator could create a hazard to the subject safety, endanger the study procedures or interfere with the interpretation of study results

Sponsors & Collaborators

• Turku University Hospital: lead

MeSH Terms

Conditions

Motor Activity

Interventions

Exercise

Condition Hierarchy (Ancestors)

Behavior

Intervention Hierarchy (Ancestors)

Motor Activity; Movement; Musculoskeletal Physiological Phenomena; Musculoskeletal and Neural Physiological Phenomena

Study Officials

• Pirjo Nuutila, MD, PhD

  Turku UH

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Purpose: BASIC SCIENCE
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER GOV
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: MD., Ph.D.

Study Record Dates

• First Submitted: November 27, 2017
• First Posted: December 2, 2017
• Study Start: September 17, 2013
• Primary Completion: May 27, 2015
• Study Completion: May 27, 2015
• Last Updated: January 22, 2019

Record last verified: 2019-01

Data Sharing

• IPD Sharing: Will not share