NCT02593136

Brief Summary

This study evaluates the program effectiveness of home fortification along with infant and young child feeding (IYCF) counseling as a strategy to address anemia and complementary feedings gaps in a program setting of the Integrated Family Health Initiative being implemented by CARE India (a non-profit organization) in partnership with the Government of Bihar. The study also seeks to assess the field level worker experience with counseling and dissemination of home fortification products.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
11,861

participants targeted

Target at P75+ for not_applicable

Timeline
Completed

Started Jun 2014

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

June 1, 2014

Completed
1.4 years until next milestone

First Submitted

Initial submission to the registry

October 29, 2015

Completed
1 day until next milestone

First Posted

Study publicly available on registry

October 30, 2015

Completed
4 months until next milestone

Primary Completion

Last participant's last visit for primary outcome

March 1, 2016

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

March 1, 2016

Completed
Last Updated

March 14, 2017

Status Verified

March 1, 2017

Enrollment Period

1.8 years

First QC Date

October 29, 2015

Last Update Submit

March 10, 2017

Conditions

Keywords

VitaminsPublic HealthNutrition

Outcome Measures

Primary Outcomes (3)

  • Number of home fortification sachets consumed

    The number of sachets consumed versus those received by participants within seven days of distribution.

    Within 7 days (Up to 7 days)

  • Number of home fortification sachets consumed

    The number of sachets consumed versus those received by participants within thirty one days of distribution.

    Within 31 days (Up to 31 days)

  • Change in hemoglobin concentration

    Hemoglobin concentration will be collected by taking a small blood sample via finger or heal prick. A hemoglobin level below 7 g/dl is considered severe anemia.

    Baseline (month 0), Endline (month 12)

Secondary Outcomes (13)

  • Frequency of home visits

    Up to 12 months

  • Frequency of home fortification sachet distribution

    Up to twelve months

  • Change in body length

    Baseline (month 0), Endline (month 12)

  • Change in body weight

    Baseline (month 0), Endline (month 12)

  • Complementary Feeding Rate

    Month 6 (Up to six months)

  • +8 more secondary outcomes

Study Arms (2)

Home Fortification and Counseling

EXPERIMENTAL

Participants aged 6 to 18 months will receive a daily supplement of vitamins and minerals in dry powder form to be taken once daily for up to nine months or up to 240 sachets. Participant caregivers will also receive improved young child feeding practices (IYCF) counseling from a front line worker.

Dietary Supplement: Home Fortification Product (HFP)Other: Infant and Young Child Feeding (IYCF) Practices Counseling

Improved Child Feeding Practices (IYCF) Counseling

EXPERIMENTAL

Participants ages 6 to 18 months will receive improved young child feeding practices (IYCF) counseling from a front line worker.

Other: Infant and Young Child Feeding (IYCF) Practices Counseling

Interventions

The home fortification product (HFP) is a sachet containing multiple vitamins and nutrients as follows: Iron (Ferrous Fumarate) 12.5 mg Zinc (Zinc Gluconate) 5 mg Folic Acid 0.160 mg Vitamin-A (Vit-A Acetate) 0.30 mg Vitamin-C (Ascorbic Acid) 30 mg Vitamin-B12 0.9 mcg Iodine 90 mcg Maltodextrin (Base)

Home Fortification and Counseling

Infant and Young Child Feeding (IYCF) Practices Counseling provides direction on breast milk and milk feeding, food variety, and frequency for caregivers of children aged 6 to 18 months. Participants will be visited at least monthly by a field line worker for IYCF counseling and educational materials distribution.

Home Fortification and CounselingImproved Child Feeding Practices (IYCF) Counseling

Eligibility Criteria

Age6 Months - 18 Months
Sexall
Healthy VolunteersNo
Age GroupsChild (0-17)

You may qualify if:

  • Randomly selected children living within Health-Sub Centers (HSC) in West Champaran Bihar

You may not qualify if:

  • Children less than six months of age
  • Children greater than eighteen months of age

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

CARE-India

Patna, Bihar, India

Location

Related Publications (2)

  • Keats EC, Das JK, Bhutta ZA. Micronutrient powders and diarrhoea risk in infants and young children - Authors' reply. Lancet Child Adolesc Health. 2021 Aug;5(8):e29-e30. doi: 10.1016/S2352-4642(21)00164-4. No abstract available.

  • Larson LM, Young MF, Ramakrishnan U, Webb Girard A, Verma P, Chaudhuri I, Srikantiah S, Martorell R. A Cross-Sectional Survey in Rural Bihar, India, Indicates That Nutritional Status, Diet, and Stimulation Are Associated with Motor and Mental Development in Young Children. J Nutr. 2017 Aug;147(8):1578-1585. doi: 10.3945/jn.117.251231. Epub 2017 Jun 14.

MeSH Terms

Conditions

AnemiaMalnutrition

Condition Hierarchy (Ancestors)

Hematologic DiseasesHemic and Lymphatic DiseasesNutrition DisordersNutritional and Metabolic Diseases

Study Officials

  • Reynaldo Martorell, PhD

    Emory University

    PRINCIPAL INVESTIGATOR

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
NONE
Purpose
OTHER
Intervention Model
PARALLEL
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Professor

Study Record Dates

First Submitted

October 29, 2015

First Posted

October 30, 2015

Study Start

June 1, 2014

Primary Completion

March 1, 2016

Study Completion

March 1, 2016

Last Updated

March 14, 2017

Record last verified: 2017-03

Data Sharing

IPD Sharing
Will not share

Locations