Study of Motor Representations in Healthy Subjects and Amnestic MCI

NCT02574182 | Completed

• 1 other identifier: CHU PROMOTEUR 2014/32
• Study Type: observational
• Target: 97
• Locations: 1 country
• Sites: 1

Brief Summary

Walking, Brain and Functional Magnetic Resonance Imaging Study of motor representations in healthy subjects and amnesic MCI.

Conditions

Mild Cognitive Impairment

Keywords

Mild Cognitive Impairment; Magnetic Resonance Imaging

Outcome Measures

Primary Outcomes (1)

• Review and compare mapping cerebral activation in brain MRI

  Review and compare mapping brain activation in healthy about MRI according to age (\<40 years and\> 60 years) and MCI through the combination of two paradigms: on mechanically simulated by Korvit® boots and imagination the walk. The primary endpoint is the analysis of fMRI brain mapping in accordance with the different paradigms of acquisition. The MRI data will be the subject of a specific statistical treatment, via dedicated software, which will be implemented under the control of the investigators who have conducted such an fMRI analysis in previous studies. Various brain mapping can be established from the data collected. It may include statistical comparisons between different preselected regions, and different experimental conditions, or correlation studies between brain activation and clinical parameters.

  One day

Secondary Outcomes (4)

• Review and compare mapping brain activation in healthy subjects and MCI MRI in imagination alone walking.

  One day

• Study of differences in terms of activation of brain mapping

  One day

• study of functional connectivity of sensorimotor cortex obtained by fMRI resting in the subject MCI.

  One day

• study of the potential effects on muscle activation, and autonomic nervous system

  One day

Study Arms (3)

Control subjects under 40 years

Brain MRI Simulated walking with Corvit boots Records gait parameters on Gaitrite carpet

Radiation: Brain MRI

Control subjects over 60 years

Brain MRI Simulated walking with Corvit boots Records gait parameters on Gaitrite carpet

Radiation: Brain MRI

MCI subjects over 60 years

Brain MRI Simulated walking with Corvit boots Records gait parameters on Gaitrite carpet

Radiation: Brain MRI

Interventions

Brain MRI RADIATION

Brain MRI (Magnetic Resonance Imaging) brain is a painless test that allows to visualize the different brain structures. Korvit, device made up of 2 shoes which reproduces the feeling to go. The Korvit® system appears possible to analyze the activated cerebral zones and to thus try to better understand the operation of the brain during walk. The GAITRite is a carpet for recording the walking operating parameters

Also known as: KORVIT, GAITRite

Control subjects over 60 years; Control subjects under 40 years; MCI subjects over 60 years

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

* Healthy volunteers over 18 and under 40. * Healthy volunteers over 60 years. * MCI patient over 60 years

You may qualify if:

• Obtaining the signature of consent to participation in the study
• Age above 18 years
• Lack dementia as NICDS-ADRDA criteria
• Lack of pre-existing musculoskeletal disorders, regardless of the cause (except MCI).
• Absence of a history of stroke or other cerebrovascular disease with spinal sensorimotor sequelae.
• No cons-indication for performing a brain MRI.
• Witennses, population of young (\<40 years)
• Witnesses ,population of older subjects (\> 60 years)
• Witnesses Lack of MCI
• MCI patients, criteria MCI criteria according to Dubois

You may not qualify if:

• Refusal of MRI.
• Contraindications to brain MRI.

Sponsors & Collaborators

• University Hospital, Angers: lead

Study Sites (1)

University Hospital Angers

Angers, Pays de la Loire Region, 49933, France

Location

Related Publications (5)

• Dinomais M, Minassian AT, Tuilier T, Delion M, Wilke M, N'Guyen S, Richard I, Aube C, Menei P. Functional MRI comparison of passive and active movement: possible inhibitory role of supplementary motor area. Neuroreport. 2009 Oct 7;20(15):1351-5. doi: 10.1097/WNR.0b013e328330cd43.

  PMID: 19734813 BACKGROUND

• Beauchet O, Allali G, Berrut G, Hommet C, Dubost V, Assal F. Gait analysis in demented subjects: Interests and perspectives. Neuropsychiatr Dis Treat. 2008 Feb;4(1):155-60. doi: 10.2147/ndt.s2070.

  PMID: 18728766 BACKGROUND

• Rimmer E, Wojciechowska M, Stave C, Sganga A, O'Connell B. Implications of the Facing Dementia Survey for the general population, patients and caregivers across Europe. Int J Clin Pract Suppl. 2005 Mar;(146):17-24. doi: 10.1111/j.1368-504x.2005.00482.x.

  PMID: 15801187 BACKGROUND

• Ogawa S, Lee TM, Nayak AS, Glynn P. Oxygenation-sensitive contrast in magnetic resonance image of rodent brain at high magnetic fields. Magn Reson Med. 1990 Apr;14(1):68-78. doi: 10.1002/mrm.1910140108.

  PMID: 2161986 BACKGROUND

• Beauchet O, Allali G, Launay C, Herrmann FR, Annweiler C. Gait variability at fast-pace walking speed: a biomarker of mild cognitive impairment? J Nutr Health Aging. 2013 Mar;17(3):235-9. doi: 10.1007/s12603-012-0394-4.

  PMID: 23459976 BACKGROUND

MeSH Terms

Conditions

Cognitive Dysfunction

Condition Hierarchy (Ancestors)

Cognition Disorders; Neurocognitive Disorders; Mental Disorders

Study Officials

• Michael Dinomais, MD

  UH Angers

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER GOV
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: September 18, 2015
• First Posted: October 12, 2015
• Study Start: February 24, 2015
• Primary Completion: May 13, 2017
• Study Completion: May 13, 2017
• Last Updated: July 12, 2021

Record last verified: 2021-07

Locations

FR (1)