Magnetic Resonance Imaging-based Comparative Research in Different Mild Cognitive Impairment Subtype

NCT02706210 | Unknown

• 1 other identifier: MudanjiangMU
• Study Type: observational
• Target: 160
• Locations: 1 country
• Sites: 1

Brief Summary

Dementia is one of the main chronic non-communicable diseases associated with disability, institutionalization, and mortality among elderly individuals. Alzheimer's disease (AD) and vascular dementia (VD) are considered to be the main types of dementia. A widely shared view is that future treatment strategies need to focus on treatment of the earliest stages of the disease. Mild cognitive impairment (MCI) constitutes an intermediate stage between normal aging and dementia. Vascular cognitive disorders (VCD) is an umbrella term representing a wide spectrum of cognitive disorder evoked by or associated with vascular causes. It encompasses patients suffering from a range of types of cognitive impairment, from mild impairment to VD. VCD predementia (VCD-P) is at the same stage of MCI. Amnestic MCI (aMCI) is a subtype of MCI, which is also considered to be the clinical transition stage between normal aging and AD, and has been applied to detect the emerging dementia. In VCD, infarcts or profuse white matter disease are considered the cause of cognitive decline. By contrast, AD is one of the most common progressive neurodegenerative disorders thought to be caused by amyloid aggregation and the formation of tau tangles. Both VCD-P and aMCI have a deficit in cognitive domains, and may have the same chief complaints of memory deficit. If it can be clear which will turn into what type of dementia in patients with cognitive impairment stage, it can not only make us more early intervention treatment to the patients, but also can save a lot of social resources and economic costs in clinic. By applying the resting state functional magnetic resonance (fMRI), structural magnetic resonance imaging (sMRI) and diffusion tensor magnetic resonance imaging (DTI) multimodal magnetic resonance (NMR) technology, the project comprehensive analysis comparison of neurodegenerative and blood vessels of brain function in patients with mild cognitive impairment and structural abnormalities connection mode. This project in order to reveal the cognitive impairment disease neural circuits in the development of the network connection and its change rule. People can further understand the pathogenesis of cognitive impairment, discover new will provide a scientific basis for prevention, diagnosis and treatment.

Conditions

Mild Cognitive Impairment

Keywords

Mild Cognitive Impairment; Diffusion Tensor Imaging

Outcome Measures

Primary Outcomes (3)

• fractional anisotropy (FA)

  The diffusion tensor matrix would be generated from a series of diffusion weighted images, then the three eigenvalues or diffusivities, would be calculated by matrix diagonalization. FA represents the degree of anisotropy of the diffusion of water molecules in axons and decreased FA is a frequent correlate of brain tissue injury. It is a DTI parameter without units.

  about 3-5 years after they had a complaint of cognitive deficit

• axial diffusivity (AxD)

  AxD represents the water diffusivity parallel to the axonal fibers, and therefore commonly linked to the microstructure of myelin. It is a DTI parameter without units.

  about 3-5 years after they had a complaint of cognitive deficit

• radial diffusivity (RD)

  RD components of the diffusion metric provide indices of axonal integrity, measured as longitudinal diffusivity, and myelin integrity. It is a DTI parameter without units.

  about 3-5 years after they had a complaint of cognitive deficit

Study Arms (2)

vascular cognitive disorders pre-dementia (VCD-P)

amnestic mild cognitive impairment (aMCI)

Eligibility Criteria

• Age: 45 Years - 80 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

The recruited patients were outpatients who were registered at the neurology department.

You may qualify if:

• For all the participants
• Right-hand Chinese Han people
• Sufficient with Mandarin language
• For VCD-P group,
• Clinical diagnosis of Vascular cognitive disorders
• Between the stage of cognitive normal and dementia
• Clinical diagnosis of subcortical vascular diseases
• For aMCI group
• Clinical diagnosis of aMCI
• Between the stage of cognitive normal and dementia
• The hippocampal atrophy confirmed by structural MRI

You may not qualify if:

• psychiatric disease, neurological disorder and systemic disease
• a suffering of visual abnormalities, severe aphasia or palsy
• any medical or psychological conditions

Sponsors & Collaborators

• Mudanjiang Medical University: lead
• National Natural Science Foundation of China: collaborator

Study Sites (1)

Department of Neurology, Hongqi Hospital of Mudanjiang Medical Universiy

Mudanjiang, Heilongjiang, China

RECRUITING

Related Publications (1)

• Yu Y, Zhao W, Li S, Yin C. MRI-based comparative study of different mild cognitive impairment subtypes: protocol for an observational case-control study. BMJ Open. 2017 Mar 8;7(3):e013432. doi: 10.1136/bmjopen-2016-013432.

  PMID: 28274963 DERIVED

MeSH Terms

Conditions

Cognitive Dysfunction

Condition Hierarchy (Ancestors)

Cognition Disorders; Neurocognitive Disorders; Mental Disorders

Central Study Contacts

Changhao Yin

CONTACT

86 13845307558; yinchanghao7916@sina.com

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: MD

Study Record Dates

• First Submitted: January 28, 2016
• First Posted: March 11, 2016
• Study Start: September 1, 2015
• Primary Completion: June 1, 2017
• Study Completion: December 1, 2018
• Last Updated: March 1, 2017

Record last verified: 2016-03

Locations

CN (1)