NCT02542800

Brief Summary

Schemas describe mental structures storing recurrent and organized pattern of information. Schemas may have a strong influence on the process of storing and retrieving new information into memory. Previous approaches in the cognitive neuroscience of memory have entirely focused on the individual dimension of preexisting schemas. In the real world though, much of the researchers' experiences and knowledge are collective or shared. Such social-cultural frameworks stored in collective memory may also reshape and reconfigure the construction of individual memories. Attempting to ascertain the influence of collective schema on the neural substrates of individual memories using cutting-edge brain imaging methods represents the challenge that MULTIBRAIN2 seeks to tackle. To achieve this goal, the researchers will record brain activity during MRI scanning sessions in a group of 24 participants while they are performing an encoding followed by episodic memory retrieval tasks on pictures of the World War II Memorial of Caen. This study will seek to identify brain areas of the prefrontal cortex encoding the organization of knowledge in collective memory using multivariate analyses of brain activity patterns, and then to understand how such regions might modulate the recruitment of the hippocampus during episodic memory retrieval using analyses of effective connectivity. The organization of knowledge in collective memory is measured in parallel through 1) the analysis of French social memory of World War II using a corpus of thousand of television and radio shows from the National Institute of Audiovisual, and 2) an internet task measuring the organization of shared individual knowledge about World War II. Once collected, these data will help us to understand how collective schemas may shape the organization of individual memories.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
26

participants targeted

Target at below P25 for not_applicable

Timeline
Completed

Started Sep 2015

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

September 1, 2015

Completed
3 days until next milestone

First Submitted

Initial submission to the registry

September 4, 2015

Completed
3 days until next milestone

First Posted

Study publicly available on registry

September 7, 2015

Completed
1.7 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

June 1, 2017

Completed
1 day until next milestone

Study Completion

Last participant's last visit for all outcomes

June 2, 2017

Completed
Last Updated

September 4, 2025

Status Verified

October 1, 2017

Enrollment Period

1.8 years

First QC Date

September 4, 2015

Last Update Submit

August 28, 2025

Conditions

Episodic Memory

Outcome Measures

Primary Outcomes (1)

  • Blood Oxygen Level Dependent (BOLD) response as measured with fMRI

    1 hour

Study Arms (1)

Healthy participants

EXPERIMENTAL
Behavioral: Episodic memory taskDevice: fMRI

Interventions

Episodic memory taskBEHAVIORAL
Healthy participants
fMRIDEVICE
Healthy participants

Eligibility Criteria

Age20 Years - 38 Years
Sexall
Healthy VolunteersYes
Age GroupsAdult (18-64)

You may qualify if:

  • Healthy participants between 20 and 38 years old
  • Affiliated to the French national health care system
  • French native speaker
  • Having not visited the Memorial of Caen for the past four years
  • Right-handed
  • At least 2 years of education after graduating from high school
  • Body mass \< 30kg/m2
  • Signed written consent form

You may not qualify if:

  • Pregnancy or intent to get pregnant
  • Person deprived of their liberty
  • Person hospitalized without consent
  • Minor
  • Protected adults or people unable to give informed consent
  • History of neurological or psychiatric disorders or existence of traumatic brain injury with loss of consciousness for more than one hour
  • History of cancer with the last 5 years, excluding squamous cell carcinomas
  • Alcoholism, antecedents of chronic alcoholism or drugs abuse
  • Severe psychiatric disorders (according to DSM V diagnostic criteria) or psychological troubles which could affect participant's judgment
  • Use of medication that may interfere with cognitive or cerebral functioning
  • Presence of visual or hearing troubles that may compromise participant's ability to participate in the study
  • MRI Contraindications

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

GIP Cyceron

Caen, 14074, France

Location

Related Publications (1)

  • Gagnepain P, Vallee T, Heiden S, Decorde M, Gauvain JL, Laurent A, Klein-Peschanski C, Viader F, Peschanski D, Eustache F. Collective memory shapes the organization of individual memories in the medial prefrontal cortex. Nat Hum Behav. 2020 Feb;4(2):189-200. doi: 10.1038/s41562-019-0779-z. Epub 2019 Dec 16.

    PMID: 31844272BACKGROUND

MeSH Terms

Interventions

Magnetic Resonance Imaging

Intervention Hierarchy (Ancestors)

TomographyDiagnostic ImagingDiagnostic Techniques and ProceduresDiagnosis

Study Officials

  • Fausto Viader, PUPH

    University Hospital, Caen

    PRINCIPAL INVESTIGATOR

Study Design

Study Type
interventional
Phase
not applicable
Allocation
NA
Masking
NONE
Purpose
BASIC SCIENCE
Intervention Model
SINGLE GROUP
Sponsor Type
OTHER GOV
Responsible Party
SPONSOR

Study Record Dates

First Submitted

September 4, 2015

First Posted

September 7, 2015

Study Start

September 1, 2015

Primary Completion

June 1, 2017

Study Completion

June 2, 2017

Last Updated

September 4, 2025

Record last verified: 2017-10

Locations

FR(1)