NCT05974371

Brief Summary

The purpose of this study is to assess how emotional memories integrate and interfere with one another over time. We will be using a multi-session experimental paradigm consisting of two encoding sessions and one retrieval session. Participants will either complete these sessions online or in-person, with the latter collecting functional magnetic resonance imaging during the two encoding sessions.

Trial Health

63
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Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
150

participants targeted

Target at P75+ for not_applicable

Timeline
16mo left

Started Aug 2024

Typical duration for not_applicable

Geographic Reach
1 country

1 active site

Status
not yet recruiting

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

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Study Timeline

Key milestones and dates

Study Progress59%
Aug 2024Aug 2027

First Submitted

Initial submission to the registry

July 26, 2023

Completed
8 days until next milestone

First Posted

Study publicly available on registry

August 3, 2023

Completed
12 months until next milestone

Study Start

First participant enrolled

August 1, 2024

Completed
3 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

August 1, 2027

Expected
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

August 1, 2027

Last Updated

August 3, 2023

Status Verified

July 1, 2023

Enrollment Period

3 years

First QC Date

July 26, 2023

Last Update Submit

July 26, 2023

Conditions

Episodic Memory

Outcome Measures

Primary Outcomes (2)

  • Memory for the Associated Words

    During the memory recall task on Day 3, participants will be shown a cue word (A) and asked to recall the corresponding associates from Day 1 (B) and Day 2 (C) by typing their response in a blank text field. Participants will also report their confidence in these memories from 1 (not at all confident) to 9 (extremely confident).

    Day 3

  • fMRI Measured Neural Reactivity (Blood Oxygen-Level Dependent Signal)

    fMRI data from Day 1 and Day 2 will be used to perform whole-brain analyses of neural response during encoding, as well as compute neural pattern similarity scores between AB and AC pairs from same- or differently-valenced contexts. Our primary hypothesis is that the similarity of neural patterns in the dorsomedial prefrontal cortex will predict memory performance on Day 3.

    Day 2

Secondary Outcomes (2)

  • Source Memory

    Day 3

  • Change in Resting-State Functional Connectivity

    Day 2

Study Arms (1)

Emotional memory updating paradigm

EXPERIMENTAL

All participants will encode AB/AC word pairs shown with images that have differing emotional valence (positive, negative, or neutral)

Other: emotional context similarity

Interventions

emotional context similarityOTHER

On Day 1, all participants will encode AB neutral word pairs (e.g., Pencil - Car) shown with positive, negative, or neutral images. On Day 2, all participants will encode AC neutral words pairs (e.g., Pencil - Book) alongside images of either the same or different valence. The emotional similarity of AB (Day 1) and AC (Day 2) image contexts (i.e., the independent variable) will consist of the following conditions: positive-positive, positive-negative, negative-negative, negative-positive, neutral-neutral, neutral-positive, and neutral-negative.

Emotional memory updating paradigm

Eligibility Criteria

Age18 Years - 39 Years
Sexall
Healthy VolunteersYes
Age GroupsAdult (18-64)

You may qualify if:

  • All participants: willing and able to follow the protocol
  • All participants: fluent in English
  • Online participants: online account in the crowdsourcing platform that will be used (e.g., Prolific)

You may not qualify if:

  • All participants: history of a psychiatric or neurological condition, and/or current psychotropic drug use (indicated by the participant)
  • fMRI participants: pregnant, metal in body (incl piercings or metallic makeup if unwilling to remove), unable to lie still for duration of scan (e.g., due to pain), Meniere's disease, claustrophobic, or other contraindication for MRI as determined my MRI technician, left-handed

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Boston College

Chestnut Hill, Massachusetts, 02467, United States

Location

Central Study Contacts

Erin Sibley

CONTACT

617.552.1758erin.sibley@bc.edu

Study Design

Study Type
interventional
Phase
not applicable
Allocation
NA
Masking
NONE
Purpose
BASIC SCIENCE
Intervention Model
SINGLE GROUP
Sponsor Type
OTHER
Responsible Party
SPONSOR

Study Record Dates

First Submitted

July 26, 2023

First Posted

August 3, 2023

Study Start

August 1, 2024

Primary Completion (Estimated)

August 1, 2027

Study Completion (Estimated)

August 1, 2027

Last Updated

August 3, 2023

Record last verified: 2023-07

Data Sharing

IPD Sharing
Will share

All IPD that underlie results in a publication.

Shared Documents
STUDY PROTOCOL, SAP, ANALYTIC CODE
Time Frame
De-identified data will be available for access and sharing as soon as the final version of the manuscript is accepted for publication
Access Criteria
Because data will be de-identified, these data will be posted on an open access website.

Locations

US(1)