Quantifying Abnormalities in Cortical Activation Associated With Auditory Hallucinations Using Functional Magnetic Resonance Imaging

NCT00288340 | Completed

• 2 other identifiers: 050978NARSAD
• Study Type: interventional
• Target: 60
• Locations: 1 country
• Sites: 1

Brief Summary

The goal of the project is to characterize abnormalities in brain structure and function related to schizophrenia. The investigators will use advanced magnetic resonance imaging (MRI) techniques to measure the degree and distribution of neuronal activity during specific cognitive tasks, alterations in neuronal connectivity, and how these are related to disease symptoms and treatment.

Conditions

Schizophrenia; Schizoaffective Disorder; Hallucinations

Keywords

psychotic disorders; auditory hallucinations; brain structure; psychiatric disorder with auditory hallucinations (at least one every 20 minutes); schizophrenia/schizoaffective disorder without auditory hallucinations

Outcome Measures

Primary Outcomes (1)

• characterize abnormalities in brain structure and function related to schizophrenia

  two scans over a six month period

Study Arms (1)

1,2

ACTIVE COMPARATOR

Device: functional magnetic resonance imaging

Interventions

functional magnetic resonance imaging DEVICE

1,2

Eligibility Criteria

• Age: 18 Years - 65 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Investigators will study subjects who:
• Are between the ages of 18 and 65.
• Meet diagnostic criteria for any psychiatric disorder with auditory hallucinations (at least one every 20 minutes) including schizophrenia/schizoaffective disorder OR schizophrenia/schizoaffective disorder without auditory hallucinations.
• Have been treated with an antipsychotic drug for hallucinations at least three months or are unmedicated
• Are willing to change their current antipsychotic medication if indicated
• Are able to provide written consent
• Normal controls must :
• Be between the ages of 18 and 65
• Not meet the diagnostic criteria for schizophrenia or schizoaffective disorder or other psychiatric disorder involving hallucinations
• Not currently be treated with an antipsychotic drug
• Be able to provide written consent

You may not qualify if:

• Subjects and normal controls will be excluded from participation if there is:
• Evidence of non-psychiatric, chronic central nervous system (CNS) disease (such as brain injury or neurological disease)
• Contraindication to MRI, including prior claustrophobic reaction and severe movement disorder
• A recent change in menstrual status other than recent changes in oral or implanted contraceptive use (for females)
• A positive pregnancy result (for females)

Sponsors & Collaborators

• Vanderbilt University: lead
• National Alliance for Research on Schizophrenia and Depression: collaborator

Study Sites (1)

Vanderbilt University Medical Center

Nashville, Tennessee, 37212, United States

Location

MeSH Terms

Conditions

Schizophrenia; Psychotic Disorders; Hallucinations

Interventions

Magnetic Resonance Imaging

Condition Hierarchy (Ancestors)

Schizophrenia Spectrum and Other Psychotic Disorders; Mental Disorders; Perceptual Disorders; Neurobehavioral Manifestations; Neurologic Manifestations; Nervous System Diseases; Signs and Symptoms; Pathological Conditions, Signs and Symptoms

Intervention Hierarchy (Ancestors)

Tomography; Diagnostic Imaging; Diagnostic Techniques and Procedures; Diagnosis

Study Officials

• Adam Anderson, Ph.D.

  Vanderbilt University Medical Center

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NON RANDOMIZED
• Masking: NONE
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: February 6, 2006
• First Posted: February 7, 2006
• Study Start: January 1, 2006
• Primary Completion: August 1, 2006
• Study Completion: August 1, 2006
• Last Updated: April 19, 2017

Record last verified: 2017-04

Locations

US (1)